| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
,
,,¶
*
Department of Cell Biology, Neurobiology, and Anatomy,
Department of Physiology,
The Burn and Shock Trauma Institute,
§
Department of Microbiology and Immunology, and
¶
Department of Surgery, Loyola University Medical Center, Maywood, IL 60153
The neurotransmitter norepinephrine (NE) binds to the ß2-adrenergic receptor (ß2AR) expressed on various immune cells to influence cell homing, proliferation, and function. Previous reports showed that NE stimulation of the B cell ß2AR is necessary for the maintenance of an optimal primary and secondary Th2 cell-dependent Ab response in vivo. In the present study we investigated the mechanism by which activation of Ag-specific CD4+ Th2 cells and B cells in vivo by a soluble protein Ag increases NE release in the spleen and bone marrow. Our model system used scid mice that were reconstituted with a clone of keyhole limpet hemocyanin-specific Th2 cells and trinitrophenyl-specific B cells. Following immunization, the rate of NE release in the spleen and bone marrow was determined using [3H]NE turnover analysis. Immunization of reconstituted scid mice with a cognate Ag increased the rate of NE release in the spleen and bone marrow 18–25 h, but not 1–8 h, following immunization. In contrast, immunization of mice with a noncognate Ag had no effect on the rate of NE release at any time. The cognate Ag-induced increase in NE release was partially blocked by ganglionic blockade with chlorisondamine, suggesting a role for both pre- and postganglionic signals in regulating NE release. Thus, activation of Ag-specific Th2 cells and B cells in vivo by a soluble protein Ag increases the rate of NE release and turnover in the spleen and bone marrow 18–25 h after immunization.
This article has been cited by other articles:
|
|
 |
|
  D. Roosterman, T. Goerge, S. W. Schneider, N. W. Bunnett, and M. Steinhoff Neuronal control of skin function: the skin as a neuroimmunoendocrine organ. Physiol Rev, October 1, 2006; 86(4): 1309 - 1379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Pongratz, J. W. McAlees, D. H. Conrad, R. S. Erbe, K. M. Haas, and V. M. Sanders The Level of IgE Produced by a B Cell Is Regulated by Norepinephrine in a p38 MAPK- and CD23-Dependent Manner. J. Immunol., September 1, 2006; 177(5): 2926 - 2938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. W. Kin and V. M. Sanders It takes nerve to tell T and B cells what to do J. Leukoc. Biol., June 1, 2006; 79(6): 1093 - 1104. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Ganta, F. Blecha, R. R. Ganta, B. G. Helwig, S. Parimi, N. Lu, R. J. Fels, T. I. Musch, and M. J. Kenney Hyperthermia-enhanced splenic cytokine gene expression is mediated by the sympathetic nervous system Physiol Genomics, October 4, 2004; 19(2): 175 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Podojil, N. W. Kin, and V. M. Sanders CD86 and {beta}2-Adrenergic Receptor Signaling Pathways, Respectively, Increase Oct-2 and OCA-B Expression and Binding to the 3'-IgH Enhancer in B Cells J. Biol. Chem., May 28, 2004; 279(22): 23394 - 23404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Podojil and V. M. Sanders Selective Regulation of Mature IgG1 Transcription by CD86 and {beta}2-Adrenergic Receptor Stimulation J. Immunol., May 15, 2003; 170(10): 5143 - 5151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. Kohm, A. Mozaffarian, and V. M. Sanders B Cell Receptor- and {beta}2-Adrenergic Receptor-Induced Regulation of B7-2 (CD86) Expression in B Cells J. Immunol., June 15, 2002; 168(12): 6314 - 6322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Friedman and D. A. Lawrence Environmental Stress Mediates Changes in Neuroimmunological Interactions Toxicol. Sci., May 1, 2002; 67(1): 4 - 10. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Kohm and V. M. Sanders Norepinephrine and beta 2-Adrenergic Receptor Stimulation Regulate CD4+ T and B Lymphocyte Function in Vitro and in Vivo Pharmacol. Rev., December 1, 2001; 53(4): 487 - 525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Swanson, W. T. Lee, and V. M. Sanders IFN-{{gamma}} Production by Th1 Cells Generated from Naive CD4+ T Cells Exposed to Norepinephrine J. Immunol., January 1, 2001; 166(1): 232 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Kasprowicz, A. P. Kohm, M. T. Berton, A. J. Chruscinski, A. Sharpe, and V. M. Sanders Stimulation of the B Cell Receptor, CD86 (B7-2), and the {beta}2-Adrenergic Receptor Intrinsically Modulates the Level of IgG1 and IgE Produced per B Cell J. Immunol., July 15, 2000; 165(2): 680 - 690. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
