| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
Production in T Cells Mediating Chronic Resistance to the Intracellular Pathogen, Toxoplasma gondii
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
IL-12 is required for the development of IFN-
-dependent
resistance to intracellular pathogens but is not thought to play a
major role in its maintenance. To directly assess the requirement for
continuous IL-12 signaling in long-term cell-mediated immunity,
recombinant cytokine was transiently administered to IL-12
p40-deficient mice during the first 2 wk of infection with the
intracellular pathogen Toxoplasma gondii. As expected,
these animals survived the acute phase and established chronic
infections. However, 4–6 wk after IL-12 withdrawal, the mice exhibited
increased brain cyst burdens and succumbed to toxoplasmic encephalitis.
Reactivation was associated with a loss of T-dependent IFN-
production without a concomitant increase in Th2 cytokine expression.
Importantly, parasite Ag-induced IFN- synthesis by purified T cells
from these animals could be restored by in vitro exposure to IL-12.
These results argue that endogenous IL-12 is required for the long-term
maintenance of IFN--dependent resistance against intracellular
pathogens.
This article has been cited by other articles:
|
|
 |
|
  M. K. Middleton, A. M. Zukas, T. Rubinstein, M. Kinder, E. H. Wilson, P. Zhu, I. A. Blair, C. A. Hunter, and E. Pure 12/15-Lipoxygenase-Dependent Myeloid Production of Interleukin-12 Is Essential for Resistance to Chronic Toxoplasmosis Infect. Immun., December 1, 2009; 77(12): 5690 - 5700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Y. Wan and R. A. Flavell How Diverse--CD4 Effector T Cells and their Functions J Mol Cell Biol, October 1, 2009; 1(1): 20 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hu, Y. Wang, and L. Xie Potential Role of Macrophages in Experimental Keratomycosis Invest. Ophthalmol. Vis. Sci., May 1, 2009; 50(5): 2087 - 2094. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rate, J. W. Upham, A. Bosco, K. L. McKenna, and P. G. Holt Airway Epithelial Cells Regulate the Functional Phenotype of Locally Differentiating Dendritic Cells: Implications for the Pathogenesis of Infectious and Allergic Airway Disease J. Immunol., January 1, 2009; 182(1): 72 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Pakpour, C. Zaph, and P. Scott The Central Memory CD4+ T Cell Population Generated during Leishmania major Infection Requires IL-12 to Produce IFN-{gamma} J. Immunol., June 15, 2008; 180(12): 8299 - 8305. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Wilson, S. Matthews, and G. S. Yap IL-12 Signaling Drives CD8+ T Cell IFN-{gamma} Production and Differentiation of KLRG1+ Effector Subpopulations during Toxoplasma gondii Infection J. Immunol., May 1, 2008; 180(9): 5935 - 5945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. LaRosa, J. S. Stumhofer, A. E. Gelman, A. H. Rahman, D. K. Taylor, C. A. Hunter, and L. A. Turka T cell expression of MyD88 is required for resistance to Toxoplasma gondii PNAS, March 11, 2008; 105(10): 3855 - 3860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Price, K. R. Simpfendorfer, R. R. Mantena, J. Holden, W. R. Heath, N. van Rooijen, R. A. Strugnell, and O. L. C. Wijburg Gamma Interferon-Independent Effects of Interleukin-12 on Immunity to Salmonella enterica Serovar Typhimurium Infect. Immun., December 1, 2007; 75(12): 5753 - 5762. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Nakano, C. Nishiyama, S. Kanada, Y. Niwa, N. Shimokawa, H. Ushio, M. Nishiyama, K. Okumura, and H. Ogawa Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections Blood, June 1, 2007; 109(11): 4846 - 4855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-H. Liu, F. S. Machado, R. Guo, K. E. Nichols, A. W. Burks, J. C. Aliberti, and X.-P. Zhong Diacylglycerol kinase {zeta} regulates microbial recognition and host resistance to Toxoplasma gondii J. Exp. Med., April 16, 2007; 204(4): 781 - 792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Jirmanova, D. Jankovic, A. J. Fornace Jr., and J. D. Ashwell Gadd45{alpha} Regulates p38-Dependent Dendritic Cell Cytokine Production and Th1 Differentiation J. Immunol., April 1, 2007; 178(7): 4153 - 4158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jankovic, M. C. Kullberg, C. G. Feng, R. S. Goldszmid, C. M. Collazo, M. Wilson, T. A. Wynn, M. Kamanaka, R. A. Flavell, and A. Sher Conventional T-bet+Foxp3- Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection J. Exp. Med., February 19, 2007; 204(2): 273 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Wozniak, A. A. Ryan, and W. J. Britton Interleukin-23 Restores Immunity to Mycobacterium tuberculosis Infection in IL-12p40-Deficient Mice and Is Not Required for the Development of IL-17-Secreting T Cell Responses J. Immunol., December 15, 2006; 177(12): 8684 - 8692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Liu, Y.-t. Fan, A. Dias, L. Esper, R. A. Corn, A. Bafica, F. S. Machado, and J. Aliberti Cutting Edge: Dendritic Cells Are Essential for In Vivo IL-12 Production and Development of Resistance against Toxoplasma gondii Infection in Mice J. Immunol., July 1, 2006; 177(1): 31 - 35. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nembrini, B. Abel, M. Kopf, and B. J. Marsland Strong TCR Signaling, TLR Ligands, and Cytokine Redundancies Ensure Robust Development of Type 1 Effector T Cells. J. Immunol., June 15, 2006; 176(12): 7180 - 7188. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. W. Lee, S. Bennouna, and E. Y. Denkers Screening for Toxoplasma gondii-Regulated Transcriptional Responses in Lipopolysaccharide-Activated Macrophages Infect. Immun., March 1, 2006; 74(3): 1916 - 1923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wuthrich, T. Warner, and B. S. Klein IL-12 Is Required for Induction but Not Maintenance of Protective, Memory Responses to Blastomyces dermatitidis: Implications for Vaccine Development in Immune-Deficient Hosts J. Immunol., October 15, 2005; 175(8): 5288 - 5297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. L. King and B. M. Segal Cutting Edge: IL-12 Induces CD4+CD25- T Cell Activation in the Presence of T Regulatory Cells J. Immunol., July 15, 2005; 175(2): 641 - 645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Feng, D. Jankovic, M. Kullberg, A. Cheever, C. A. Scanga, S. Hieny, P. Caspar, G. S. Yap, and A. Sher Maintenance of Pulmonary Th1 Effector Function in Chronic Tuberculosis Requires Persistent IL-12 Production J. Immunol., April 1, 2005; 174(7): 4185 - 4192. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Lieberman, F. Cardillo, A. M. Owyang, D. M. Rennick, D. J. Cua, R. A. Kastelein, and C. A. Hunter IL-23 Provides a Limited Mechanism of Resistance to Acute Toxoplasmosis in the Absence of IL-12 J. Immunol., August 1, 2004; 173(3): 1887 - 1893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Nolt and J. L. Flynn Interleukin-12 Therapy Reduces the Number of Immune Cells and Pathology in Lungs of Mice Infected with Mycobacterium tuberculosis Infect. Immun., May 1, 2004; 72(5): 2976 - 2988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. Robben, D. G. Mordue, S. M. Truscott, K. Takeda, S. Akira, and L. D. Sibley Production of IL-12 by Macrophages Infected with Toxoplasma gondii Depends on the Parasite Genotype J. Immunol., March 15, 2004; 172(6): 3686 - 3694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. G. Mordue and L. D. Sibley A novel population of Gr-1+-activated macrophages induced during acute toxoplasmosis J. Leukoc. Biol., December 1, 2003; 74(6): 1015 - 1025. [Abstract] [Full Text]
|
|
|
|
|
|
B. Fux, C. V. Rodrigues, R. W. Portela, N. M. Silva, C. Su, D. Sibley, R. W. A. Vitor, and R. T. Gazzinelli Role of Cytokines and Major Histocompatibility Complex Restriction in Mouse Resistance to Infection with a Natural Recombinant Strain (Type I-III) of Toxoplasma gondii Infect. Immun., November 1, 2003; 71(11): 6392 - 6401. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. D. Nguyen, G. Bigaignon, D. Markine-Goriaynoff, H. Heremans, T. N. Nguyen, G. Warnier, M. Delmee, M. Warny, S. F. Wolf, C. Uyttenhove, et al. Virulent Toxoplasma gondii strain RH promotes T-cell-independent overproduction of proinflammatory cytokines IL12 and {gamma}-interferon J. Med. Microbiol., October 1, 2003; 52(10): 869 - 876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Shaw, V. Boyartchuk, S. Wong, M. Karaghiosoff, J. Ragimbeau, S. Pellegrini, M. Muller, W. F. Dietrich, and G. S. Yap A natural mutation in the Tyk2 pseudokinase domain underlies altered susceptibility of B10.Q/J mice to infection and autoimmunity PNAS, September 30, 2003; 100(20): 11594 - 11599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Dimier-Poisson, F. Aline, M.-N. Mevelec, C. Beauvillain, D. Buzoni-Gatel, and D. Bout Protective Mucosal Th2 Immune Response against Toxoplasma gondii by Murine Mesenteric Lymph Node Dendritic Cells Infect. Immun., September 1, 2003; 71(9): 5254 - 5265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kang, O. Liesenfeld, J. S. Remington, J. Claflin, X. Wang, and Y. Suzuki TCR V{beta}8+ T Cells Prevent Development of Toxoplasmic Encephalitis in BALB/c Mice Genetically Resistant to the Disease J. Immunol., April 15, 2003; 170(8): 4254 - 4259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Upham, P. T. Lee, B. J. Holt, T. Heaton, S. L. Prescott, M. J. Sharp, P. D. Sly, and P. G. Holt Development of Interleukin-12-Producing Capacity throughout Childhood Infect. Immun., December 1, 2002; 70(12): 6583 - 6588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Collazo, G. S. Yap, S. Hieny, P. Caspar, C. G. Feng, G. A. Taylor, and A. Sher The Function of Gamma Interferon-Inducible GTP-Binding Protein IGTP in Host Resistance to Toxoplasma gondii Is Stat1 Dependent and Requires Expression in Both Hematopoietic and Nonhematopoietic Cellular Compartments Infect. Immun., December 1, 2002; 70(12): 6933 - 6939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Pien, K. B. Nguyen, L. Malmgaard, A. R. Satoskar, and C. A. Biron A Unique Mechanism for Innate Cytokine Promotion of T Cell Responses to Viral Infections J. Immunol., November 15, 2002; 169(10): 5827 - 5837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Aliberti, C. Serhan, and A. Sher Parasite-induced Lipoxin A4 Is an Endogenous Regulator of IL-12 Production and Immunopathology in Toxoplasma gondii Infection J. Exp. Med., November 4, 2002; 196(9): 1253 - 1262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Jung, R. LaCourse, L. Ryan, and R. J. North Evidence Inconsistent with a Negative Influence of T Helper 2 Cells on Protection Afforded by a Dominant T Helper 1 Response against Mycobacterium tuberculosis Lung Infection in Mice Infect. Immun., November 1, 2002; 70(11): 6436 - 6443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. W. Pascual, T. Trunkle, and J. Sura Fimbriated Salmonella enterica Serovar Typhimurium Abates Initial Inflammatory Responses by Macrophages Infect. Immun., August 1, 2002; 70(8): 4273 - 4281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Y. Park, B. Hondowicz, M. Kopf, and P. Scott The Role of IL-12 in Maintaining Resistance to Leishmania major J. Immunol., June 1, 2002; 168(11): 5771 - 5777. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Dabbagh, M. E. Dahl, P. Stepick-Biek, and D. B. Lewis Toll-Like Receptor 4 Is Required for Optimal Development of Th2 Immune Responses: Role of Dendritic Cells J. Immunol., May 1, 2002; 168(9): 4524 - 4530. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Elkins, A. Cooper, S. M. Colombini, S. C. Cowley, and T. L. Kieffer In Vivo Clearance of an Intracellular Bacterium, Francisella tularensis LVS, Is Dependent on the p40 Subunit of Interleukin-12 (IL-12) but Not on IL-12 p70 Infect. Immun., April 1, 2002; 70(4): 1936 - 1948. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. MacDonald and E. J. Pearce Cutting Edge: Polarized Th Cell Response Induction by Transferred Antigen-Pulsed Dendritic Cells Is Dependent on IL-4 or IL-12 Production by Recipient Cells J. Immunol., April 1, 2002; 168(7): 3127 - 3130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ko, A. Gendron-Fitzpatrick, and G. A. Splitter Susceptibility of IFN Regulatory Factor-1 and IFN Consensus Sequence Binding Protein-Deficient Mice to Brucellosis J. Immunol., March 1, 2002; 168(5): 2433 - 2440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Ansari, A. E. Mayne, J. B. Sundstrom, P. Bostik, B. Grimm, J. D. Altman, and F. Villinger Administration of Recombinant Rhesus Interleukin-12 during Acute Simian Immunodeficiency Virus (SIV) Infection Leads to Decreased Viral Loads Associated with Prolonged Survival in SIVmac251-Infected Rhesus Macaques J. Virol., February 15, 2002; 76(4): 1731 - 1743. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Cooper, A. Kipnis, J. Turner, J. Magram, J. Ferrante, and I. M. Orme Mice Lacking Bioactive IL-12 Can Generate Protective, Antigen-Specific Cellular Responses to Mycobacterial Infection Only if the IL-12 p40 Subunit Is Present J. Immunol., February 1, 2002; 168(3): 1322 - 1327. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Del Rio, S. Bennouna, J. Salinas, and E. Y. Denkers CXCR2 Deficiency Confers Impaired Neutrophil Recruitment and Increased Susceptibility During Toxoplasma gondii Infection J. Immunol., December 1, 2001; 167(11): 6503 - 6509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Michailowsky, N. M. Silva, C. D. Rocha, L. Q. Vieira, J. Lannes-Vieira, and R. T. Gazzinelli Pivotal Role of Interleukin-12 and Interferon-{gamma} Axis in Controlling Tissue Parasitism and Inflammation in the Heart and Central Nervous System during Trypanosoma cruzi Infection Am. J. Pathol., November 1, 2001; 159(5): 1723 - 1733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.A. Taubman and T. Kawai Involvement of T-Lymphocytes in Periodontal Disease and in Direct and Indirect Induction of Bone Resorption Critical Reviews in Oral Biology & Medicine, January 1, 2001; 12(2): 125 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. J. Blader, I. D. Manger, and J. C. Boothroyd Microarray Analysis Reveals Previously Unknown Changes in Toxoplasma gondii-infected Human Cells J. Biol. Chem., June 22, 2001; 276(26): 24223 - 24231. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
