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*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*AMPICILLIN
Medline Plus Health Information
*Listeria Infections
The Journal of Immunology, 2000, 165: 6833-6839.
Copyright © 2000 by The American Association of Immunologists

Early Programming of T Cell Populations Responding to Bacterial Infection1

Roberto Mercado2,*, Sujata Vijh2,3,*, S. Elise Allen*,{dagger}, Kristen Kerksiek*,{dagger}, Ingrid M. Pilip* and Eric G. Pamer4,*,{dagger}

Sections of * Infectious Diseases and {dagger} Immunobiology, Yale University School of Medicine, New Haven, CT 06520

The duration of infection and the quantity of Ag presented in vivo are commonly assumed to influence, if not determine, the magnitude of T cell responses. Although the cessation of in vivo T cell expansion coincides with bacterial clearance in mice infected with Listeria monocytogenes, closer analysis suggests that control of T cell expansion and contraction is more complex. In this report, we show that the magnitude and kinetics of Ag-specific T cell responses are determined during the first day of bacterial infection. Expansion of Ag-specific T lymphocyte populations and generation of T cell memory are independent of the duration and severity of in vivo bacterial infection. Our studies indicate that the Ag-specific T cell response to L. monocytogenes is programmed before the peak of the innate inflammatory response and in vivo bacterial replication.




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