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*
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia; and
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, United Kingdom
Three distinct subtypes of dendritic cells (DC) are present in
mouse spleen, separable as CD4-8
-,
CD4+8-, and
CD4-8+ DC. We have tested whether these
represent stages of development or activation within one DC lineage, or
whether they represent separate DC lineages. All three DC subtypes
appear relatively mature by many criteria, but all retain a capacity to
phagocytose particulate material in vivo. Although further maturation
or activation could be induced by bacterially derived stimuli,
phagocytic capacity was retained, and no DC subtype was converted to
the other. Continuous elimination of CD4+8- DC
by Ab depletion had no effect on the levels of the other DC subtypes.
Bromodeoxyuridine labeling experiments indicated that all three DC
subtypes have a rapid turnover (half-life, 1.5–2.9 days) in the
spleen, with none being the precursor of another. The three DC subtypes
showed different kinetics of development from bone marrow precursors.
The CD8+ spleen DC, apparently the most mature,
displayed an extremely rapid turnover based on bromodeoxyuridine uptake
and the fastest generation from bone marrow precursors. In conclusion,
the three splenic DC subtypes behave as rapidly turning over products
of three independent developmental streams.
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N. S. Wilson, D. El-Sukkari, G. T. Belz, C. M. Smith, R. J. Steptoe, W. R. Heath, K. Shortman, and J. A. Villadangos Most lymphoid organ dendritic cell types are phenotypically and functionally immature Blood, September 15, 2003; 102(6): 2187 - 2194. [Abstract] [Full Text] [PDF]
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G. Lugo-Villarino, R. Maldonado-Lopez, R. Possemato, C. Penaranda, and L. H. Glimcher T-bet is required for optimal production of IFN-{gamma} and antigen-specific T cell activation by dendritic cells PNAS, June 24, 2003; 100(13): 7749 - 7754. [Abstract] [Full Text] [PDF]
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L. Bonifaz, D. Bonnyay, K. Mahnke, M. Rivera, M. C. Nussenzweig, and R. M. Steinman Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance J. Exp. Med., December 16, 2002; 196(12): 1627 - 1638. [Abstract] [Full Text] [PDF]
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G. Schiavoni, F. Mattei, P. Sestili, P. Borghi, M. Venditti, H. C. Morse III, F. Belardelli, and L. Gabriele ICSBP Is Essential for the Development of Mouse Type I Interferon-producing Cells and for the Generation and Activation of CD8{alpha}+ Dendritic Cells J. Exp. Med., December 2, 2002; 196(11): 1415 - 1425. [Abstract] [Full Text] [PDF]
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M. O'Keeffe, H. Hochrein, D. Vremec, I. Caminschi, J. L. Miller, E. M. Anders, L. Wu, M. H. Lahoud, S. Henri, B. Scott, et al. Mouse Plasmacytoid Cells: Long-lived Cells, Heterogeneous in Surface Phenotype and Function, that Differentiate Into CD8+ Dendritic Cells Only after Microbial Stimulus J. Exp. Med., November 18, 2002; 196(10): 1307 - 1319. [Abstract] [Full Text] [PDF]
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M. Wykes, K. P. A. MacDonald, M. Tran, R. J. Quin, P. X. Xing, S. J. Gendler, D. N. J. Hart, and M. A. McGuckin MUC1 epithelial mucin (CD227) is expressed by activated dendritic cells J. Leukoc. Biol., October 1, 2002; 72(4): 692 - 701. [Abstract] [Full Text] [PDF]
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G. Miller, V. G. Pillarisetty, A. B. Shah, S. Lahrs, Z. Xing, and R. P. DeMatteo Endogenous Granulocyte-Macrophage Colony-Stimulating Factor Overexpression In Vivo Results in the Long-Term Recruitment of a Distinct Dendritic Cell Population with Enhanced Immunostimulatory Function J. Immunol., September 15, 2002; 169(6): 2875 - 2885. [Abstract] [Full Text] [PDF]
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A. Nopora and T. Brocker Bcl-2 Controls Dendritic Cell Longevity In Vivo J. Immunol., September 15, 2002; 169(6): 3006 - 3014. [Abstract] [Full Text] [PDF]
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A. T. Kamath, S. Henri, F. Battye, D. F. Tough, and K. Shortman Developmental kinetics and lifespan of dendritic cells in mouse lymphoid organs Blood, August 13, 2002; 100(5): 1734 - 1741. [Abstract] [Full Text] [PDF]
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S. Henri, J. Curtis, H. Hochrein, D. Vremec, K. Shortman, and E. Handman Hierarchy of Susceptibility of Dendritic Cell Subsets to Infection by Leishmania major: Inverse Relationship to Interleukin-12 Production Infect. Immun., July 1, 2002; 70(7): 3874 - 3880. [Abstract] [Full Text] [PDF]
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U. Yrlid and M. J. Wick Antigen Presentation Capacity and Cytokine Production by Murine Splenic Dendritic Cell Subsets upon Salmonella Encounter J. Immunol., July 1, 2002; 169(1): 108 - 116. [Abstract] [Full Text] [PDF]
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O. Schulz, D. J. Pennington, K. Hodivala-Dilke, M. Febbraio, and C. Reis e Sousa CD36 or {alpha}v{beta}3 and {alpha}v{beta}5 Integrins Are Not Essential for MHC Class I Cross-Presentation of Cell-Associated Antigen by CD8{alpha}+ Murine Dendritic Cells J. Immunol., June 15, 2002; 168(12): 6057 - 6065. [Abstract] [Full Text] [PDF]
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S. J. Prasad and C. C. Goodnow Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo Int. Immunol., June 1, 2002; 14(6): 677 - 684. [Abstract] [Full Text] [PDF]
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T. A. Ferguson, J. Herndon, B. Elzey, T. S. Griffith, S. Schoenberger, and D. R. Green Uptake of Apoptotic Antigen-Coupled Cells by Lymphoid Dendritic Cells and Cross-Priming of CD8+ T Cells Produce Active Immune Unresponsiveness J. Immunol., June 1, 2002; 168(11): 5589 - 5595. [Abstract] [Full Text] [PDF]
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T. Iyoda, S. Shimoyama, K. Liu, Y. Omatsu, Y. Akiyama, Y. Maeda, K. Takahara, R. M. Steinman, and K. Inaba The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo J. Exp. Med., May 20, 2002; 195(10): 1289 - 1302. [Abstract] [Full Text] [PDF]
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E. Muraille, C. De Trez, B. Pajak, M. Brait, J. Urbain, and O. Leo T Cell-Dependent Maturation of Dendritic Cells in Response to Bacterial Superantigens J. Immunol., May 1, 2002; 168(9): 4352 - 4360. [Abstract] [Full Text] [PDF]
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A. D. McLellan, M. Kapp, A. Eggert, C. Linden, U. Bommhardt, E.-B. Brocker, U. Kammerer, and E. Kampgen Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression Blood, March 15, 2002; 99(6): 2084 - 2093. [Abstract] [Full Text] [PDF]
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M. O'Keeffe, H. Hochrein, D. Vremec, J. Pooley, R. Evans, S. Woulfe, and K. Shortman Effects of administration of progenipoietin 1, Flt-3 ligand, granulocyte colony-stimulating factor, and pegylated granulocyte-macrophage colony-stimulating factor on dendritic cell subsets in mice Blood, March 15, 2002; 99(6): 2122 - 2130. [Abstract] [Full Text] [PDF]
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Y. Valdez, W. Mah, M. M. Winslow, L. Xu, P. Ling, and S. E. Townsend Major Histocompatibility Complex Class II Presentation of Cell-associated Antigen Is Mediated by CD8{alpha}+ Dendritic Cells In Vivo J. Exp. Med., March 11, 2002; 195(6): 683 - 694. [Abstract] [Full Text] [PDF]
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T. Teshima, P. Reddy, K. P. Lowler, M. A. KuKuruga, C. Liu, K. R. Cooke, and J. L. M. Ferrara Flt3 ligand therapy for recipients of allogeneic bone marrow transplants expands host CD8alpha + dendritic cells and reduces experimental acute graft-versus-host disease Blood, March 1, 2002; 99(5): 1825 - 1832. [Abstract] [Full Text] [PDF]
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P. Martin, S. R. Ruiz, G. M. del Hoyo, F. Anjuere, H. H. Vargas, M. Lopez-Bravo, and C. Ardavin Dramatic increase in lymph node dendritic cell number during infection by the mouse mammary tumor virus occurs by a CD62L-dependent blood-borne DC recruitment Blood, February 15, 2002; 99(4): 1282 - 1288. [Abstract] [Full Text] [PDF]
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X. Jiao, R. Lo-Man, P. Guermonprez, L. Fiette, E. Deriaud, S. Burgaud, B. Gicquel, N. Winter, and C. Leclerc Dendritic Cells Are Host Cells for Mycobacteria In Vivo That Trigger Innate and Acquired Immunity J. Immunol., February 1, 2002; 168(3): 1294 - 1301. [Abstract] [Full Text] [PDF]
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 M. F. Lipscomb and B. J. Masten Dendritic Cells: Immune Regulators in Health and Disease Physiol Rev, January 1, 2002; 82(1): 97 - 130. [Abstract] [Full Text] [PDF]
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L. Wu, A. D'Amico, H. Hochrein, M. O'Keeffe, K. Shortman, and K. Lucas Development of thymic and splenic dendritic cell populations from different hemopoietic precursors Blood, December 1, 2001; 98(12): 3376 - 3382. [Abstract] [Full Text] [PDF]
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J. H. Cho, J. W. Youn, and Y. C. Sung Cross-Priming as a Predominant Mechanism for Inducing CD8+ T Cell Responses in Gene Gun DNA Immunization J. Immunol., November 15, 2001; 167(10): 5549 - 5557. [Abstract] [Full Text] [PDF]
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B. C. Urban, T. Mwangi, A. Ross, S. Kinyanjui, M. Mosobo, O. Kai, B. Lowe, K. Marsh, and D. J. Roberts Peripheral blood dendritic cells in children with acute Plasmodium falciparum malaria Blood, November 1, 2001; 98(9): 2859 - 2861. [Abstract] [Full Text] [PDF]
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I. Caminschi, K. M. Lucas, M. A. O'Keeffe, H. Hochrein, Y. Laabi, F. Kontgen, A. M. Lew, K. Shortman, and M. D. Wright Molecular Cloning of F4/80-Like-Receptor, a Seven-Span Membrane Protein Expressed Differentially by Dendritic Cell and Monocyte-Macrophage Subpopulations J. Immunol., October 1, 2001; 167(7): 3570 - 3576. [Abstract] [Full Text] [PDF]
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M. L. Fields, C. L. Sokol, A. Eaton-Bassiri, S.-j. Seo, M. P. Madaio, and J. Erikson Fas/Fas Ligand Deficiency Results in Altered Localization of Anti-Double-Stranded DNA B Cells and Dendritic Cells J. Immunol., August 15, 2001; 167(4): 2370 - 2378. [Abstract] [Full Text] [PDF]
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