| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia; and
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, United Kingdom
Three distinct subtypes of dendritic cells (DC) are present in
mouse spleen, separable as CD4-8
-,
CD4+8-, and
CD4-8+ DC. We have tested whether these
represent stages of development or activation within one DC lineage, or
whether they represent separate DC lineages. All three DC subtypes
appear relatively mature by many criteria, but all retain a capacity to
phagocytose particulate material in vivo. Although further maturation
or activation could be induced by bacterially derived stimuli,
phagocytic capacity was retained, and no DC subtype was converted to
the other. Continuous elimination of CD4+8- DC
by Ab depletion had no effect on the levels of the other DC subtypes.
Bromodeoxyuridine labeling experiments indicated that all three DC
subtypes have a rapid turnover (half-life, 1.5–2.9 days) in the
spleen, with none being the precursor of another. The three DC subtypes
showed different kinetics of development from bone marrow precursors.
The CD8+ spleen DC, apparently the most mature,
displayed an extremely rapid turnover based on bromodeoxyuridine uptake
and the fastest generation from bone marrow precursors. In conclusion,
the three splenic DC subtypes behave as rapidly turning over products
of three independent developmental streams.
This article has been cited by other articles:
|
|
 |
|
  A. M. Marleau, K. L. Summers, and B. Singh Differential Contributions of APC Subsets to T Cell Activation in Nonobese Diabetic Mice J. Immunol., April 15, 2008; 180(8): 5235 - 5249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Lukacs-Kornek, S. Burgdorf, L. Diehl, S. Specht, M. Kornek, and C. Kurts The Kidney-Renal Lymph Node-System Contributes to Cross-Tolerance against Innocuous Circulating Antigen J. Immunol., January 15, 2008; 180(2): 706 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Maroof and P. M. Kaye Temporal Regulation of Interleukin-12p70 (IL-12p70) and IL-12-Related Cytokines in Splenic Dendritic Cell Subsets during Leishmania donovani Infection Infect. Immun., January 1, 2008; 76(1): 239 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xu, Y. Zhan, A. M. Lew, S. H. Naik, and M. H. Kershaw Differential Development of Murine Dendritic Cells by GM-CSF versus Flt3 Ligand Has Implications for Inflammation and Trafficking J. Immunol., December 1, 2007; 179(11): 7577 - 7584. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Diao, E. Winter, W. Chen, F. Xu, and M. S. Cattral Antigen Transmission by Replicating Antigen-Bearing Dendritic Cells J. Immunol., September 1, 2007; 179(5): 2713 - 2721. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Perona-Wright, S. M. Anderton, S. E. M. Howie, and D. Gray IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune disease Int. Immunol., September 1, 2007; 19(9): 1123 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. H. Tan and H. C. O'Neill Concise Review: Dendritic Cell Development in the Context of the Spleen Microenvironment Stem Cells, September 1, 2007; 25(9): 2139 - 2145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. L. W. Chang, N. Baumgarth, M. K. Eberhardt, C. Y. D. Lee, C. A. Baron, J. P. Gregg, and P. A. Barry Exposure of Myeloid Dendritic Cells to Exogenous or Endogenous IL-10 during Maturation Determines Their Longevity J. Immunol., June 15, 2007; 178(12): 7794 - 7804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Qian, H. An, Y. Yu, S. Liu, and X. Cao TLR agonists induce regulatory dendritic cells to recruit Th1 cells via preferential IP-10 secretion and inhibit Th1 proliferation Blood, April 15, 2007; 109(8): 3308 - 3315. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. T. Belz, L. Zhang, M. D. H. Lay, F. Kupresanin, and M. P. Davenport Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell PNAS, April 10, 2007; 104(15): 6341 - 6346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Fiorina, M. Jurewicz, K. Tanaka, N. Behazin, A. Augello, A. Vergani, U. Von Adrian, N. R. Smith, M. H. Sayegh, and R. Abdi Characterization of Donor Dendritic Cells and Enhancement of Dendritic Cell Efflux With cc-Chemokine Ligand 21: A Novel Strategy to Prolong Islet Allograft Survival Diabetes, April 1, 2007; 56(4): 912 - 920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Vremec, M. O'Keeffe, H. Hochrein, M. Fuchsberger, I. Caminschi, M. Lahoud, and K. Shortman Production of interferons by dendritic cells, plasmacytoid cells, natural killer cells, and interferon-producing killer dendritic cells Blood, February 1, 2007; 109(3): 1165 - 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Varol, L. Landsman, D. K. Fogg, L. Greenshtein, B. Gildor, R. Margalit, V. Kalchenko, F. Geissmann, and S. Jung Monocytes give rise to mucosal, but not splenic, conventional dendritic cells J. Exp. Med., January 22, 2007; 204(1): 171 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Yadav, D. J. Zammit, L. Lefrancois, and A. T. Vella Effects of LPS-mediated bystander activation in the innate immune system J. Leukoc. Biol., December 1, 2006; 80(6): 1251 - 1261. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bogunovic, F. Ginhoux, A. Wagers, M. Loubeau, L. M. Isola, L. Lubrano, V. Najfeld, R. G. Phelps, C. Grosskreutz, E. Scigliano, et al. Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men J. Exp. Med., November 27, 2006; 203(12): 2627 - 2638. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Pradhan, J. Genebriera, W. L. Denning, K. Felix, C. A. Elmets, and L. Timares CD4 T Cell-Induced, Bid-Dependent Apoptosis of Cutaneous Dendritic Cells Regulates T Cell Expansion and Immune Responses J. Immunol., November 1, 2006; 177(9): 5956 - 5967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Durakovic, K. B. Bezak, M. Skarica, V. Radojcic, E. J. Fuchs, G. F. Murphy, and L. Luznik Host-Derived Langerhans Cells Persist after MHC-Matched Allografting Independent of Donor T Cells and Critically Influence the Alloresponses Mediated by Donor Lymphocyte Infusions J. Immunol., October 1, 2006; 177(7): 4414 - 4425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Raine, P. Zaccone, P. Mastroeni, and A. Cooke Salmonella typhimurium Infection in Nonobese Diabetic Mice Generates Immunomodulatory Dendritic Cells Able to Prevent Type 1 Diabetes J. Immunol., August 15, 2006; 177(4): 2224 - 2233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Tang, Z. Guo, M. Zhang, J. Wang, G. Chen, and X. Cao Endothelial stroma programs hematopoietic stem cells to differentiate into regulatory dendritic cells through IL-10 Blood, August 15, 2006; 108(4): 1189 - 1197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. Garrod, C. K. Chang, F.-C. Liu, T. V. Brennan, R. D. Foster, and S.-M. Kang Targeted Lymphoid Homing of Dendritic Cells Is Required for Prolongation of Allograft Survival J. Immunol., July 15, 2006; 177(2): 863 - 868. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Mattei, G. Schiavoni, P. Borghi, M. Venditti, I. Canini, P. Sestili, I. Pietraforte, H. C. Morse III, C. Ramoni, F. Belardelli, et al. ICSBP/IRF-8 differentially regulates antigen uptake during dendritic-cell development and affects antigen presentation to CD4+ T cells Blood, July 15, 2006; 108(2): 609 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Lahoud, A. I. Proietto, K. H. Gartlan, S. Kitsoulis, J. Curtis, J. Wettenhall, M. Sofi, C. Daunt, M. O'Keeffe, I. Caminschi, et al. Signal Regulatory Protein Molecules Are Differentially Expressed by CD8- Dendritic Cells J. Immunol., July 1, 2006; 177(1): 372 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Diao, E. Winter, C. Cantin, W. Chen, L. Xu, D. Kelvin, J. Phillips, and M. S. Cattral In Situ Replication of Immediate Dendritic Cell (DC) Precursors Contributes to Conventional DC Homeostasis in Lymphoid Tissue. J. Immunol., June 15, 2006; 176(12): 7196 - 7206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. Sponaas, E. T. Cadman, C. Voisine, V. Harrison, A. Boonstra, A. O'Garra, and J. Langhorne Malaria infection changes the ability of splenic dendritic cell populations to stimulate antigen-specific T cells J. Exp. Med., June 12, 2006; 203(6): 1427 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hagnerud, P. P. Manna, M. Cella, A. Stenberg, W. A. Frazier, M. Colonna, and P.-A. Oldenborg Deficit of CD47 Results in a Defect of Marginal Zone Dendritic Cells, Blunted Immune Response to Particulate Antigen and Impairment of Skin Dendritic Cell Migration J. Immunol., May 15, 2006; 176(10): 5772 - 5778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Berhanu, J. Huang, S. M. Alber, S. C. Watkins, and W. J. Storkus Combinational FLt3 Ligand and Granulocyte Macrophage Colony-Stimulating Factor Treatment Promotes Enhanced Tumor Infiltration by Dendritic Cells and Antitumor CD8+ T-Cell Cross-priming but Is Ineffective as a Therapy. Cancer Res., May 1, 2006; 66(9): 4895 - 4903. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H. Schimmelpfennig, S. Schulz, C. Arber, J. Baker, I. Tarner, J. McBride, C. H. Contag, and R. S. Negrin Ex Vivo Expanded Dendritic Cells Home to T-Cell Zones of Lymphoid Organs and Survive in Vivo after Allogeneic Bone Marrow Transplantation Am. J. Pathol., November 1, 2005; 167(5): 1321 - 1331. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yamaoka, B. Min, Y.-J. Zhou, W. E. Paul, and J. J. O'Shea Jak3 negatively regulates dendritic-cell cytokine production and survival Blood, November 1, 2005; 106(9): 3227 - 3233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. H. Tan and H. C. O'Neill Maturation requirements for dendritic cells in T cell stimulation leading to tolerance versus immunity J. Leukoc. Biol., August 1, 2005; 78(2): 319 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Galibert, G. S. Diemer, Z. Liu, R. S. Johnson, J. L. Smith, T. Walzer, M. R. Comeau, C. T. Rauch, M. F. Wolfson, R. A. Sorensen, et al. Nectin-like Protein 2 Defines a Subset of T-cell Zone Dendritic Cells and Is a Ligand for Class-I-restricted T-cell-associated Molecule J. Biol. Chem., June 10, 2005; 280(23): 21955 - 21964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Liu, X. Bi, S. Xu, and J. Xiang Tumor-Infiltrating Dendritic Cell Subsets of Progressive or Regressive Tumors Induce Suppressive or Protective Immune Responses Cancer Res., June 1, 2005; 65(11): 4955 - 4962. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. H. Naik, A. I. Proietto, N. S. Wilson, A. Dakic, P. Schnorrer, M. Fuchsberger, M. H. Lahoud, M. O'Keeffe, Q.-x. Shao, W.-f. Chen, et al. Cutting Edge: Generation of Splenic CD8+ and CD8- Dendritic Cell Equivalents in Fms-Like Tyrosine Kinase 3 Ligand Bone Marrow Cultures J. Immunol., June 1, 2005; 174(11): 6592 - 6597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Boisgerault, P. Rueda, C. M. Sun, S. Hervas-Stubbs, M. Rojas, and C. Leclerc Cross-Priming of T Cell Responses by Synthetic Microspheres Carrying a CD8+ T Cell Epitope Requires an Adjuvant Signal J. Immunol., March 15, 2005; 174(6): 3432 - 3439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Westermann, U. Bode, A. Sahle, U. Speck, N. Karin, E. B. Bell, K. Kalies, and A. Gebert Naive, Effector, and Memory T Lymphocytes Efficiently Scan Dendritic Cells In Vivo: Contact Frequency in T Cell Zones of Secondary Lymphoid Organs Does Not Depend on LFA-1 Expression and Facilitates Survival of Effector T Cells J. Immunol., March 1, 2005; 174(5): 2517 - 2524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schlecht, J. Loucka, H. Najar, P. Sebo, and C. Leclerc Antigen Targeting to CD11b Allows Efficient Presentation of CD4+ and CD8+ T Cell Epitopes and In Vivo Th1-Polarized T Cell Priming J. Immunol., November 15, 2004; 173(10): 6089 - 6097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Bixel, S. Kloep, S. Butz, B. Petri, B. Engelhardt, and D. Vestweber Mouse CD99 participates in T-cell recruitment into inflamed skin Blood, November 15, 2004; 104(10): 3205 - 3213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Regner, X. Martinez, E. Belnoue, C.-M. Sun, F. Boisgerault, P.-H. Lambert, C. Leclerc, and C.-A. Siegrist Partial Activation of Neonatal CD11c+ Dendritic Cells and Induction of Adult-Like CD8+ Cytotoxic T Cell Responses by Synthetic Microspheres J. Immunol., August 15, 2004; 173(4): 2669 - 2674. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Ritter, F. Wiede, D. Mielenz, Z. Kiafard, J. Zwirner, and H. Korner Analysis of the CCR7 expression on murine bone marrow-derived and spleen dendritic cells J. Leukoc. Biol., August 1, 2004; 76(2): 472 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Diao, E. Winter, W. Chen, C. Cantin, and M. S. Cattral Characterization of Distinct Conventional and Plasmacytoid Dendritic Cell-Committed Precursors in Murine Bone Marrow J. Immunol., August 1, 2004; 173(3): 1826 - 1833. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. F. Anderson, M. Lucas, L. Gutierrez-Kobeh, A. E. Field, and D. M. Mosser T Cell Biasing by Activated Dendritic Cells J. Immunol., July 15, 2004; 173(2): 955 - 961. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J. de Heer, H. Hammad, T. Soullie, D. Hijdra, N. Vos, M. A.M. Willart, H. C. Hoogsteden, and B. N. Lambrecht Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen J. Exp. Med., July 6, 2004; 200(1): 89 - 98. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. O'Neill, H. L. Wilson, B. Quah, J. L. Abbey, G. Despars, and K. Ni Dendritic Cell Development in Long-Term Spleen Stromal Cultures Stem Cells, July 1, 2004; 22(4): 475 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-i. Fujii, K. Liu, C. Smith, A. J. Bonito, and R. M. Steinman The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation J. Exp. Med., June 21, 2004; 199(12): 1607 - 1618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Quah, K. Ni, and H. C. O'Neill In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity Int. Immunol., April 1, 2004; 16(4): 567 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Bonifaz, D. P. Bonnyay, A. Charalambous, D. I. Darguste, S.-I. Fujii, H. Soares, M. K. Brimnes, B. Moltedo, T. M. Moran, and R. M. Steinman In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination J. Exp. Med., March 15, 2004; 199(6): 815 - 824. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Wilson, D. El-Sukkari, and J. A. Villadangos Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis Blood, March 15, 2004; 103(6): 2187 - 2195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Schiavoni, F. Mattei, P. Borghi, P. Sestili, M. Venditti, H. C. Morse III, F. Belardelli, and L. Gabriele ICSBP is critically involved in the normal development and trafficking of Langerhans cells and dermal dendritic cells Blood, March 15, 2004; 103(6): 2221 - 2228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. T. Belz, C. M. Smith, D. Eichner, K. Shortman, G. Karupiah, F. R. Carbone, and W. R. Heath Cutting Edge: Conventional CD8{alpha}+ Dendritic Cells Are Generally Involved in Priming CTL Immunity to Viruses J. Immunol., February 15, 2004; 172(4): 1996 - 2000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Attanavanich and J. F. Kearney Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T Cells J. Immunol., January 15, 2004; 172(2): 803 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Dakic, Q.-x. Shao, A. D'Amico, M. O'Keeffe, W.-f. Chen, K. Shortman, and L. Wu Development of the Dendritic Cell System during Mouse Ontogeny J. Immunol., January 15, 2004; 172(2): 1018 - 1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Amprey, G. F. Spath, and S. A. Porcelli Inhibition of CD1 Expression in Human Dendritic Cells during Intracellular Infection with Leishmania donovani Infect. Immun., January 1, 2004; 72(1): 589 - 592. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Colino and C. M. Snapper Opposing Signals from Pathogen-Associated Molecular Patterns and IL-10 Are Critical for Optimal Dendritic Cell Induction of In Vivo Humoral Immunity to Streptococcus pneumoniae J. Immunol., October 1, 2003; 171(7): 3508 - 3519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. S. Wilson, D. El-Sukkari, G. T. Belz, C. M. Smith, R. J. Steptoe, W. R. Heath, K. Shortman, and J. A. Villadangos Most lymphoid organ dendritic cell types are phenotypically and functionally immature Blood, September 15, 2003; 102(6): 2187 - 2194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Naik, D. Vremec, L. Wu, M. O'Keeffe, and K. Shortman CD8{alpha}+ mouse spleen dendritic cells do not originate from the CD8{alpha}- dendritic cell subset Blood, July 15, 2003; 102(2): 601 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Brimnes, L. Bonifaz, R. M. Steinman, and T. M. Moran Influenza Virus-induced Dendritic Cell Maturation Is Associated with the Induction of Strong T Cell Immunity to a Coadministered, Normally Nonimmunogenic Protein J. Exp. Med., July 7, 2003; 198(1): 133 - 144. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Edwards, D. Chaussabel, S. Tomlinson, O. Schulz, A. Sher, and C. Reis e Sousa Relationships Among Murine CD11chigh Dendritic Cell Subsets as Revealed by Baseline Gene Expression Patterns J. Immunol., July 1, 2003; 171(1): 47 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lugo-Villarino, R. Maldonado-Lopez, R. Possemato, C. Penaranda, and L. H. Glimcher T-bet is required for optimal production of IFN-{gamma} and antigen-specific T cell activation by dendritic cells PNAS, June 24, 2003; 100(13): 7749 - 7754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Curtsinger, D. C. Lins, and M. F. Mescher Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells: Dissociating Proliferation and Development of Effector Function J. Exp. Med., May 5, 2003; 197(9): 1141 - 1151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Muraille, C. De Trez, B. Pajak, F. A. Torrentera, P. De Baetselier, O. Leo, and Y. Carlier Amastigote Load and Cell Surface Phenotype of Infected Cells from Lesions and Lymph Nodes of Susceptible and Resistant Mice Infected with Leishmania major Infect. Immun., May 1, 2003; 71(5): 2704 - 2715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
