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Departments of
*
Dermatology and Allergology and
Neurology, Hannover Medical University, Hannover, Germany; and
Department of Immunology, Georg-August-University, Göttingen, Germany
The C3a molecule is an anaphylatoxin of the C system with a wide
spectrum of proinflammatory effects predominantly on cells of myeloid
origin. In this study we investigated the expression of the high
affinity receptor for C3a (C3aR) in human T lymphocytes using
receptor-specific mAb. C3aR expression was detected in CD4+
and CD8+ blood- or skin-derived T cell clones (TCC) from
birch pollen-sensitized patients with atopic dermatitis. No significant
difference in C3aR expression in CD4+ or CD8+
TCCs could be observed. In contrast to C3a(desArg), C3a led to a
transient calcium flux in TCCs expressing the C3aR, whereas
C3aR-negative TCCs were unreactive. Circulating T cells from patients
suffering from severe inflammatory skin diseases expressed the C3aR,
whereas no expression of C3aR could be found in unstimulated T
lymphocytes from patients with mild inflammatory skin diseases or from
healthy individuals. Type I IFNs, which are potent stimulators of
cellular immunity, were identified as up-regulators of C3aR expression
in vitro in freshly isolated or cloned T lymphocytes. Moreover,
C3aR+ T cells were found at the sites of injection in
IFN-
-treated patients with multiple sclerosis. These data provide
direct evidence for the expression of C3aR on activated human T
lymphocytes; this may point to a biological function of C3a in T
cell-dependent diseases.
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 J. Zwirner C5a receptor expression in T lymphocytes J. Leukoc. Biol., May 1, 2007; 81(5): 1159 - 1159. [Full Text] [PDF]
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H. Boshra, T. Wang, L. Hove-Madsen, J. Hansen, J. Li, A. Matlapudi, C. J. Secombes, L. Tort, and J. O. Sunyer Characterization of a C3a Receptor in Rainbow Trout and Xenopus: The First Identification of C3a Receptors in Nonmammalian Species J. Immunol., August 15, 2005; 175(4): 2427 - 2437. [Abstract] [Full Text] [PDF]
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L. Boos, I. L. Campbell, R. Ames, R. A. Wetsel, and S. R. Barnum Deletion of the Complement Anaphylatoxin C3a Receptor Attenuates, Whereas Ectopic Expression of C3a in the Brain Exacerbates, Experimental Autoimmune Encephalomyelitis J. Immunol., October 1, 2004; 173(7): 4708 - 4714. [Abstract] [Full Text] [PDF]
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M. C. Braun, R. Y. Reins, T.-b. Li, T. J. Hollmann, R. Dutta, W. A. Rick, B.-B. Teng, and B. Ke Renal Expression of the C3a Receptor and Functional Responses of Primary Human Proximal Tubular Epithelial Cells J. Immunol., September 15, 2004; 173(6): 4190 - 4196. [Abstract] [Full Text] [PDF]
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 H. F. Ismail, J. Zhang, R. G. Lynch, Y. Wang, and D. J. Berg Role for Complement in Development of Helicobacter-Induced Gastritis in Interleukin-10-Deficient Mice Infect. Immun., December 1, 2003; 71(12): 7140 - 7148. [Abstract] [Full Text] [PDF]
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R. Reca, D. Mastellos, M. Majka, L. Marquez, J. Ratajczak, S. Franchini, A. Glodek, M. Honczarenko, L. A. Spruce, A. Janowska-Wieczorek, et al. Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1 Blood, May 15, 2003; 101(10): 3784 - 3793. [Abstract] [Full Text] [PDF]
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M. Suresh, H. Molina, M. S. Salvato, D. Mastellos, J. D. Lambris, and M. Sandor Complement Component 3 Is Required for Optimal Expansion of CD8 T Cells During a Systemic Viral Infection J. Immunol., January 15, 2003; 170(2): 788 - 794. [Abstract] [Full Text] [PDF]
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S. M. Drouin, D. B. Corry, T. J. Hollman, J. Kildsgaard, and R. A. Wetsel Absence of the Complement Anaphylatoxin C3a Receptor Suppresses Th2 Effector Functions in a Murine Model of Pulmonary Allergy J. Immunol., November 15, 2002; 169(10): 5926 - 5933. [Abstract] [Full Text] [PDF]
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S. M. Drouin, D. B. Corry, J. Kildsgaard, and R. A. Wetsel Cutting Edge: The Absence of C3 Demonstrates a Role for Complement in Th2 Effector Functions in a Murine Model of Pulmonary Allergy J. Immunol., October 15, 2001; 167(8): 4141 - 4145. [Abstract] [Full Text] [PDF]
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