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*
Department of Internal Medicine and Harold C. Simmons Arthritis Research Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235;
Department of Orthopedic Surgery, Osaka University Medical School, Osaka, Japan; and
National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD 20892
Rheumatoid arthritis (RA) is characterized by the accumulation of CD4+ memory T cells in the inflamed synovium. To address the mechanism, we analyzed chemokine receptor expression and found that the frequency of CXC chemokine receptor (CXCR)4 expressing synovial tissue CD4+ memory T cells was significantly elevated. CXCR4 expression could be enhanced by IL-15, whereas stromal cell-derived factor (SDF)-1, the ligand of CXCR4, was expressed in the RA synovium and could be increased by CD40 stimulation. SDF-1 stimulated migration of rheumatoid synovial T cells and also inhibited activation-induced apoptosis of T cells. These results indicate that SDF-1-CXCR4 interactions play important roles in CD4+ memory T cell accumulation in the RA synovium, and emphasize the role of stromal cells in regulating rheumatoid inflammation.
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K. Balabanian, J. Couderc, L. Bouchet-Delbos, A. Amara, D. Berrebi, A. Foussat, F. Baleux, A. Portier, I. Durand-Gasselin, R. L. Coffman, et al. Role of the Chemokine Stromal Cell-Derived Factor 1 in Autoantibody Production and Nephritis in Murine Lupus J. Immunol., March 15, 2003; 170(6): 3392 - 3400. [Abstract] [Full Text] [PDF]
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J. L. Pablos, B. Santiago, M. Galindo, C. Torres, M. T. Brehmer, F. J. Blanco, and F. J. Garcia-Lazaro Synoviocyte-Derived CXCL12 Is Displayed on Endothelium and Induces Angiogenesis in Rheumatoid Arthritis J. Immunol., February 15, 2003; 170(4): 2147 - 2152. [Abstract] [Full Text] [PDF]
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B. P. Leung, M. Conacher, D. Hunter, I. B. McInnes, F. Y. Liew, and J. M. Brewer A Novel Dendritic Cell-Induced Model of Erosive Inflammatory Arthritis: Distinct Roles for Dendritic Cells in T Cell Activation and Induction of Local Inflammation J. Immunol., December 15, 2002; 169(12): 7071 - 7077. [Abstract] [Full Text] [PDF]
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A. Krug, R. Uppaluri, F. Facchetti, B. G. Dorner, K. C. F. Sheehan, R. D. Schreiber, M. Cella, and M. Colonna Cutting Edge: IFN-Producing Cells Respond to CXCR3 Ligands in the Presence of CXCL12 and Secrete Inflammatory Chemokines upon Activation J. Immunol., December 1, 2002; 169(11): 6079 - 6083. [Abstract] [Full Text] [PDF]
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R. Gerli, C. Lunardi, and C. Pitzalis Unmasking the anti-inflammatory cytokine response in rheumatoid synovitis Rheumatology, December 1, 2002; 41(12): 1341 - 1345. [Full Text] [PDF]
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T. Okada, V. N. Ngo, E. H. Ekland, R. Forster, M. Lipp, D. R. Littman, and J. G. Cyster Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches J. Exp. Med., July 1, 2002; 196(1): 65 - 75. [Abstract] [Full Text] [PDF]
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S. A. Luther, A. Bidgol, D. C. Hargreaves, A. Schmidt, Y. Xu, J. Paniyadi, M. Matloubian, and J. G. Cyster Differing Activities of Homeostatic Chemokines CCL19, CCL21, and CXCL12 in Lymphocyte and Dendritic Cell Recruitment and Lymphoid Neogenesis J. Immunol., July 1, 2002; 169(1): 424 - 433. [Abstract] [Full Text] [PDF]
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F. Vinante, A. Rigo, M. T. Scupoli, and G. Pizzolo CD30 triggering by agonistic antibodies regulates CXCR4 expression and CXCL12 chemotactic activity in the cell line L540 Blood, January 1, 2002; 99(1): 52 - 60. [Abstract] [Full Text] [PDF]
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 U. Schonbeck and P. Libby CD40 Signaling and Plaque Instability Circ. Res., December 7, 2001; 89(12): 1092 - 1103. [Abstract] [Full Text] [PDF]
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T. Nanki, K. Nagasaka, K. Hayashida, Y. Saita, and N. Miyasaka Chemokines Regulate IL-6 and IL-8 Production by Fibroblast-Like Synoviocytes from Patients with Rheumatoid Arthritis J. Immunol., November 1, 2001; 167(9): 5381 - 5385. [Abstract] [Full Text] [PDF]
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P. Matthys, S. Hatse, K. Vermeire, A. Wuyts, G. Bridger, G. W. Henson, E. De Clercq, A. Billiau, and D. Schols AMD3100, a Potent and Specific Antagonist of the Stromal Cell-Derived Factor-1 Chemokine Receptor CXCR4, Inhibits Autoimmune Joint Inflammation in IFN-{gamma} Receptor-Deficient Mice J. Immunol., October 15, 2001; 167(8): 4686 - 4692. [Abstract] [Full Text] [PDF]
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 G. Aust, M. Steinert, S. Kiessling, M. Kamprad, and C. Simchen Reduced Expression of Stromal-Derived Factor 1 in Autonomous Thyroid Adenomas and Its Regulation in Thyroid-Derived Cells J. Clin. Endocrinol. Metab., July 1, 2001; 86(7): 3368 - 3376. [Abstract] [Full Text] [PDF]
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