The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Joosten, L. A. B.
Right arrow Articles by van den Berg, W. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Joosten, L. A. B.
Right arrow Articles by van den Berg, W. B.
The Journal of Immunology, 2000, 165: 6553-6558.
Copyright © 2000 by The American Association of Immunologists

An IFN-{gamma}-Independent Proinflammatory Role of IL-18 in Murine Streptococcal Cell Wall Arthritis

Leo A. B. Joosten1,*, Fons A. J. van de Loo*, Erik Lubberts*, Monique M. A. Helsen*, Mihai G. Netea{dagger}, Jos W. M. van der Meer{dagger}, Charles A. Dinarello{ddagger} and Wim B. van den Berg*

* Rheumatology Research Laboratory and {dagger} Department of Internal Medicine, University Medical Center St. Radboud, Nijmegen, The Netherlands; and {ddagger} Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80261

IL-18 is a member of the IL-1 family of proteins that exerts proinflammatory effects. It was formally known as IFN-{gamma}-inducing factor and is a pivotal cytokine for the development of Th1 responses. Apart from Th1 immune-stimulatory activity, IL-18 induces the production of proinflammatory cytokines such as TNF-{alpha} and IL-1 in vitro. The goal was to investigate the role of endogenous IL-18 in murine streptococcal cell wall (SCW)-induced arthritis. Furthermore, we investigated whether IL-18 neutralization had an impact on local TNF and IL-1 production. C57BL/6, BALB/c, and IFN-{gamma}-deficient mice were injected with 2 mg of rabbit anti-murine IL-18 Abs shortly before induction of arthritis by intra-articular injection of 25 µg of SCW fragments into the right knee joint. Suppression of joint swelling was noted on days 1 and 2 of SCW arthritis after blockade of endogenous IL-18. Analysis of local cytokine concentrations showed that IL-18, TNF-{alpha}, and IL-1{beta} levels were decreased. Severe inhibition of chondrocyte proteoglycan synthesis was seen in the vehicle-treated control animals, whereas a reversal of the inhibition of chondrocyte proteoglycan synthesis was found in the anti-IL-18-exposed animals. Blockade of endogenous IL-18 in IFN-{gamma}-deficient mice showed results similar to those found in wild-type animals, identifying a role for IL-18 that is IFN-{gamma} independent. The present study indicates that IL-18 is a proinflammatory cytokine during the onset of murine SCW arthritis, and this inflammatory role of IL-18 is IFN-{gamma} independent.




This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
C Plater-Zyberk, L A B Joosten, M M A Helsen, M I Koenders, P A Baeuerle, and W B van den Berg
Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor {alpha}-independent mouse model
Ann Rheum Dis, May 1, 2009; 68(5): 721 - 728.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. A. B. Joosten, B. Heinhuis, S. Abdollahi-Roodsaz, G. Ferwerda, L. LeBourhis, D. J. Philpott, M.-A. Nahori, C. Popa, S. A. Morre, J. W. M. van der Meer, et al.
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis
PNAS, July 1, 2008; 105(26): 9017 - 9022.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
S.-M. Dai, Z.-Z. Shan, H. Xu, and K. Nishioka
Cellular targets of interleukin-18 in rheumatoid arthritis
Ann Rheum Dis, November 1, 2007; 66(11): 1411 - 1418.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
C Plater-Zyberk, L A B Joosten, M M A Helsen, J Hepp, P A Baeuerle, and W B van den Berg
GM-CSF neutralisation suppresses inflammation and protects cartilage in acute streptococcal cell wall arthritis of mice
Ann Rheum Dis, April 1, 2007; 66(4): 452 - 457.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
C. A Dinarello
Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process
Am. J. Clinical Nutrition, February 1, 2006; 83(2): 447S - 455S.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
K. Wyburn, H. Wu, J. Yin, M. Jose, J. Eris, and S. Chadban
Macrophage-derived interleukin-18 in experimental renal allograft rejection
Nephrol. Dial. Transplant., April 1, 2005; 20(4): 699 - 706.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Schif-Zuck, J. Westermann, N. Netzer, Y. Zohar, M. Meiron, G. Wildbaum, and N. Karin
Targeted Overexpression of IL-18 Binding Protein at the Central Nervous System Overrides Flexibility in Functional Polarization of Antigen-Specific Th2 Cells
J. Immunol., April 1, 2005; 174(7): 4307 - 4315.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Goldberg, Y. Zohar, G. Wildbaum, Y. Geron, G. Maor, and N. Karin
Suppression of Ongoing Experimental Autoimmune Encephalomyelitis by Neutralizing the Function of the p28 Subunit of IL-27
J. Immunol., November 15, 2004; 173(10): 6465 - 6471.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
S-M Dai, K Nishioka, and K Yudoh
Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis: comparison with IL1{beta} and tumour necrosis factor {alpha}
Ann Rheum Dis, November 1, 2004; 63(11): 1379 - 1386.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
T Rooney, E Murphy, M Benito, P Roux-Lombard, O FitzGerald, J-M Dayer, and B Bresnihan
Synovial tissue interleukin-18 expression and the response to treatment in patients with inflammatory arthritis
Ann Rheum Dis, November 1, 2004; 63(11): 1393 - 1398.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
L. A.B. Joosten, R. L. Smeets, M. I. Koenders, L. A.M. van den Bersselaar, M. M.A. Helsen, B. Oppers-Walgreen, E. Lubberts, Y. Iwakura, F. A.J. van de Loo, and W. B. van den Berg
Interleukin-18 Promotes Joint Inflammation and Induces Interleukin-1-Driven Cartilage Destruction
Am. J. Pathol., September 1, 2004; 165(3): 959 - 967.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Goldberg, G. Wildbaum, Y. Zohar, G. Maor, and N. Karin
Suppression of Ongoing Adjuvant-Induced Arthritis by Neutralizing the Function of the p28 Subunit of IL-27
J. Immunol., July 15, 2004; 173(2): 1171 - 1178.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. A. B. Joosten, M. I. Koenders, R. L. Smeets, M. Heuvelmans-Jacobs, M. M. A. Helsen, K. Takeda, S. Akira, E. Lubberts, F. A. J. van de Loo, and W. B. van den Berg
Toll-Like Receptor 2 Pathway Drives Streptococcal Cell Wall-Induced Joint Inflammation: Critical Role of Myeloid Differentiation Factor 88
J. Immunol., December 1, 2003; 171(11): 6145 - 6153.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
F Y Liew, X-Q Wei, and I B McInnes
Role of interleukin 18 in rheumatoid arthritis
Ann Rheum Dis, November 1, 2003; 62(90002): ii48 - 50.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
C. A. Cannetti, B. P. Leung, S. Culshaw, I. B. McInnes, F. Q. Cunha, and F. Y. Liew
IL-18 Enhances Collagen-Induced Arthritis by Recruiting Neutrophils Via TNF-{alpha} and Leukotriene B4
J. Immunol., July 15, 2003; 171(2): 1009 - 1015.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. K. Banda, A. Vondracek, D. Kraus, C. A. Dinarello, S.-H. Kim, A. Bendele, G. Senaldi, and W. P. Arend
Mechanisms of Inhibition of Collagen-Induced Arthritis by Murine IL-18 Binding Protein
J. Immunol., February 15, 2003; 170(4): 2100 - 2105.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Komai-Koma, J. A. Gracie, X.-q. Wei, D. Xu, N. Thomson, I. B. McInnes, and F. Y. Liew
Chemoattraction of Human T Cells by IL-18
J. Immunol., January 15, 2003; 170(2): 1084 - 1090.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
F Y Liew and I B McInnes
Role of interleukin 15 and interleukin 18 in inflammatory response
Ann Rheum Dis, November 1, 2002; 61(90002): ii100 - 102.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. J. L. Stuyt, M. G. Netea, I. Verschueren, G. Fantuzzi, C. A. Dinarello, J. W. M. Van der Meer, and B. J. Kullberg
Role of Interleukin-18 in Host Defense against Disseminated Candida albicans Infection
Infect. Immun., June 1, 2002; 70(6): 3284 - 3286.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
O. H. Hultgren, L. Svensson, and A. Tarkowski
Critical Role of Signaling Through IL-1 Receptor for Development of Arthritis and Sepsis During Staphylococcus aureus Infection
J. Immunol., May 15, 2002; 168(10): 5207 - 5212.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Wang, C. Feliciani, B. G. Howell, I. Freed, Q. Cai, H. Watanabe, and D. N. Sauder
Contribution of Langerhans Cell-Derived IL-18 to Contact Hypersensitivity
J. Immunol., April 1, 2002; 168(7): 3303 - 3308.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-H. Kim, T. Azam, D. Novick, D.-Y. Yoon, L. L. Reznikov, P. Bufler, M. Rubinstein, and C. A. Dinarello
Identification of Amino Acid Residues Critical for Biological Activity in Human Interleukin-18
J. Biol. Chem., March 22, 2002; 277(13): 10998 - 11003.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Faggioni, R. C. Cattley, J. Guo, S. Flores, H. Brown, M. Qi, S. Yin, D. Hill, S. Scully, C. Chen, et al.
IL-18-Binding Protein Protects Against Lipopolysaccharide- Induced Lethality and Prevents the Development of Fas/Fas Ligand-Mediated Models of Liver Disease in Mice
J. Immunol., November 15, 2001; 167(10): 5913 - 5920.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. P. Leung, S. Culshaw, J. A. Gracie, D. Hunter, C. A. Canetti, C. Campbell, F. Cunha, F. Y. Liew, and I. B. McInnes
A Role for IL-18 in Neutrophil Activation
J. Immunol., September 1, 2001; 167(5): 2879 - 2886.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Chen, Y. Wei, G. C. Sharp, and H. Braley-Mullen
Induction of Experimental Autoimmune Thyroiditis in IL-12-/- Mice
J. Immunol., August 1, 2001; 167(3): 1720 - 1727.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B. Siegmund, H.-A. Lehr, G. Fantuzzi, and C. A. Dinarello
IL-1beta -converting enzyme (caspase-1) in intestinal inflammation
PNAS, November 6, 2001; 98(23): 13249 - 13254.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.