| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
T Cell Subset Can Increase Host Resistance to a Bacterial Infection1
*
Department of Immunology, National Jewish Medical and Research Center, Denver, CO 80206 and Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80262;
Department of Pathology, University of Vermont, Burlington, VT 05405; and
Department of Medical Chemistry, Kyoto University Faculty of Medicine, Kyoto, Japan
T lymphocytes have been shown to regulate immune responses
in diverse experimental systems. Because distinct T cell
subsets, as defined by the usage of certain TCR V genes, preferentially
respond in various diseases and disease models, we have hypothesized
that the various T cell subsets carry out different functions.
To test this, we compared one particular T cell subset, the
V1+ subset, which represents a major T cell type
in the lymphoid organs and blood of mice, to other subsets and to
T cells as a whole. Using Listeria monocytogenes
infection as an infectious disease model, we found that bacterial
containment improves in mice depleted of V1+ T
cells, albeit mice lacking all T cells are instead impaired in
their ability to control Listeria expansion. Our
findings indicate that V1+ T cells reduce the
ability of the innate immune system to destroy Listeria,
even though other T cells as a whole promote clearance of this
pathogen.
This article has been cited by other articles:
|
|
 |
|
  N. Jin, C. L. Roark, N. Miyahara, C. Taube, M. K. Aydintug, J. M. Wands, Y. Huang, Y.-S. Hahn, E. W. Gelfand, R. L. O'Brien, et al. Allergic Airway Hyperresponsiveness-Enhancing {gamma}{delta} T Cells Develop in Normal Untreated Mice and Fail to Produce IL-4/13, Unlike Th2 and NKT Cells J. Immunol., February 15, 2009; 182(4): 2002 - 2010. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hamada, M. Umemura, T. Shiono, K. Tanaka, A. Yahagi, M. D. Begum, K. Oshiro, Y. Okamoto, H. Watanabe, K. Kawakami, et al. IL-17A Produced by {gamma}{delta} T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver J. Immunol., September 1, 2008; 181(5): 3456 - 3463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. M. Andrew, D. J. Newton, J. E. Dalton, C. E. Egan, S. J. Goodwin, D. Tramonti, P. Scott, and S. R. Carding Delineation of the Function of a Major {gamma}{delta} T Cell Subset during Infection J. Immunol., August 1, 2005; 175(3): 1741 - 1750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Skeen, M. M. Freeman, and H. K. Ziegler Changes in peritoneal myeloid populations and their proinflammatory cytokine expression during infection with Listeria monocytogenes are altered in the absence of {gamma}/{delta} T cells J. Leukoc. Biol., July 1, 2004; 76(1): 104 - 115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Uezu, K. Kawakami, K. Miyagi, Y. Kinjo, T. Kinjo, H. Ishikawa, and A. Saito Accumulation of {gamma}{delta} T Cells in the Lungs and Their Regulatory Roles in Th1 Response and Host Defense against Pulmonary Infection with Cryptococcus neoformans J. Immunol., June 15, 2004; 172(12): 7629 - 7634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Aydintug, C. L. Roark, X. Yin, J. M. Wands, W. K. Born, and R. L. O'Brien Detection of Cell Surface Ligands for the {gamma}{delta} TCR Using Soluble TCRs J. Immunol., April 1, 2004; 172(7): 4167 - 4175. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Roark, M. K. Aydintug, J. Lewis, X. Yin, M. Lahn, Y.-S. Hahn, W. K. Born, R. E. Tigelaar, and R. L. O'Brien Subset-specific, uniform activation among V{gamma}6/V{delta}1+ {gamma}{delta} T cells elicited by inflammation J. Leukoc. Biol., January 1, 2004; 75(1): 68 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Dalton, J. Pearson, P. Scott, and S. R. Carding The Interaction of {gamma}{delta} T Cells with Activated Macrophages Is a Property of the V{gamma}1 Subset J. Immunol., December 15, 2003; 171(12): 6488 - 6494. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-H. Cui, A. Joetham, M. K. Aydintug, Y.-S. Hahn, W. K. Born, and E. W. Gelfand Reversal of Allergic Airway Hyperreactivity after Long-term Allergen Challenge Depends on {gamma}{delta} T Cells Am. J. Respir. Crit. Care Med., December 1, 2003; 168(11): 1324 - 1332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Hedges, J. C. Graff, and M. A. Jutila Transcriptional Profiling of {gamma}{delta} T Cells J. Immunol., November 15, 2003; 171(10): 4959 - 4964. [Full Text] [PDF]
|
|
|
|
|
|
Y.-S. Hahn, C. Taube, N. Jin, K. Takeda, J.-W. Park, J. M. Wands, M. K. Aydintug, C. L. Roark, M. Lahn, R. L. O'Brien, et al. V{gamma}4+ {gamma}{delta} T Cells Regulate Airway Hyperreactivity to Methacholine in Ovalbumin-Sensitized and Challenged Mice J. Immunol., September 15, 2003; 171(6): 3170 - 3178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Meissner, J. Radke, J. F. Hedges, M. White, M. Behnke, S. Bertolino, M. Abrahamsen, and M. A. Jutila Serial Analysis of Gene Expression in Circulating {gamma}{delta} T Cell Subsets Defines Distinct Immunoregulatory Phenotypes and Unexpected Gene Expression Profiles J. Immunol., January 1, 2003; 170(1): 356 - 364. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. M. Naiman, S. Blumerman, D. Alt, C. A. Bolin, R. Brown, R. Zuerner, and C. L. Baldwin Evaluation of Type 1 Immune Response in Naive and Vaccinated Animals following Challenge with Leptospira borgpetersenii Serovar Hardjo: Involvement of WC1+{gamma}{delta} and CD4 T Cells Infect. Immun., November 1, 2002; 70(11): 6147 - 6157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Wilson, J. F. Hedges, E. C. Butcher, M. Briskin, and M. A. Jutila Bovine {gamma}{delta} T Cell Subsets Express Distinct Patterns of Chemokine Responsiveness and Adhesion Molecules: A Mechanism for Tissue-Specific {gamma}{delta} T Cell Subset Accumulation J. Immunol., November 1, 2002; 169(9): 4970 - 4975. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Cardona and J. M. Teale {gamma}/{delta} T Cell-Deficient Mice Exhibit Reduced Disease Severity and Decreased Inflammatory Response in the Brain in Murine Neurocysticercosis J. Immunol., September 15, 2002; 169(6): 3163 - 3171. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lahn, A. Kanehiro, K. Takeda, J. Terry, Y.-S. Hahn, M. K. Aydintug, A. Konowal, K. Ikuta, R. L. O'Brien, E. W. Gelfand, et al. MHC class I-dependent Vgamma 4+ pulmonary T cells regulate alpha beta T cell-independent airway responsiveness PNAS, June 25, 2002; 99(13): 8850 - 8855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. E. Kennedy, M. D. Welsh, D. G. Bryson, J. P. Cassidy, F. I. Forster, C. J. Howard, R. A. Collins, and J. M. Pollock Modulation of Immune Responses to Mycobacterium bovis in Cattle Depleted of WC1+{gamma}{delta} T Cells Infect. Immun., March 1, 2002; 70(3): 1488 - 1500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Skeen, E. P. Rix, M. M. Freeman, and H. K. Ziegler Exaggerated Proinflammatory and Th1 Responses in the Absence of gamma /delta T Cells after Infection with Listeria monocytogenes Infect. Immun., December 1, 2001; 69(12): 7213 - 7223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.B. Moore, T.A. Moore, and G.B. Toews Role of T- and B-;lymphocytes in pulmonary host defences Eur. Respir. J., November 1, 2001; 18(5): 846 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. L. Wormley Jr., C. Steele, K. Wozniak, K. Fujihashi, J. R. McGhee, and P. L. Fidel Jr. Resistance of T-Cell Receptor delta -Chain-Deficient Mice to Experimental Candidaalbicans Vaginitis Infect. Immun., November 1, 2001; 69(11): 7162 - 7164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Huber, D. Graveline, W. K. Born, and R. L. O'Brien Cytokine Production by V{gamma}+-T-Cell Subsets Is an Important Factor Determining CD4+-Th-Cell Phenotype and Susceptibility of BALB/c Mice to Coxsackievirus B3-Induced Myocarditis J. Virol., July 1, 2001; 75(13): 5860 - 5869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Altincicek, J. Moll, N. Campos, G. Foerster, E. Beck, J.-F. Hoeffler, C. Grosdemange-Billiard, M. Rodriguez-Concepcion, M. Rohmer, A. Boronat, et al. Cutting Edge: Human {{gamma}}{{delta}} T Cells Are Activated by Intermediates of the 2-C-methyl-D-erythritol 4-phosphate Pathway of Isoprenoid Biosynthesis J. Immunol., March 15, 2001; 166(6): 3655 - 3658. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
