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T Cell Repertoire of CD8+ Splenocytes Selected on Nonpolymorphic MHC Class I Molecules1
*
Laboratoire de Biologie Moléculaire du Gène, Institut National de la Santé et de la Recherche Médicale U277-Institut Pasteur, Paris, France; and
Laboratoire d’Immunité Cellulaire Anti-Virale, Institut Pasteur, Paris, France
In this work, we have studied the role of the MHC class Ib
molecules in the selection and maintenance of CD8+ T
splenocytes. We have compared the CD8+ T cell repertoires
of wild-type, H-2K-deficient, H-2D-deficient, or double knockout
C57BL/6 mice. We show that the different CD8+ repertoires,
selected either by class Ia and class Ib or by class Ib molecules only,
use the various V
(AV) and V
(BV) rearrangements in the same
proportion and without biases in the CDR3 size distribution.
Furthermore, we have estimated the size of the BV repertoire in the
four different strains of mice. Interestingly, we have found that the
BV repertoire size is proportional to the overall number of
CD8+ splenocytes. This observation implies that BV
diversity is positively correlated with the number of CD8+
cells, even when the number of CD8+ splenocytes is
dramatically reduced (90% in the double knockout
mice).
This article has been cited by other articles:
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  D. C. Jay, L. M. Reed-Loisel, and P. E. Jensen Polyclonal MHC Ib-Restricted CD8+ T Cells Undergo Homeostatic Expansion in the Absence of Conventional MHC-Restricted T Cells J. Immunol., March 1, 2008; 180(5): 2805 - 2814. [Abstract] [Full Text] [PDF]
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C. Ferreira, A. Furmanski, M. Millrain, I. Bartok, P. Guillaume, R. Lees, E. Simpson, H. R. MacDonald, and J. Dyson TCR-{alpha} CDR3 Loop Audition Regulates Positive Selection J. Immunol., August 15, 2006; 177(4): 2477 - 2485. [Abstract] [Full Text] [PDF]
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J. Su, R. E. Berg, S. Murray, and J. Forman Thymus-Dependent Memory Phenotype CD8 T Cells in Naive B6.H-2Kb-/-Db-/- Animals Mediate an Antigen-Specific Response against Listeria monocytogenes J. Immunol., November 15, 2005; 175(10): 6450 - 6457. [Abstract] [Full Text] [PDF]
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N. Anfossi, S. H. Robbins, S. Ugolini, P. Georgel, K. Hoebe, C. Bouneaud, C. Ronet, A. Kaser, C. B. DiCioccio, E. Tomasello, et al. Expansion and Function of CD8+ T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules J. Immunol., September 15, 2004; 173(6): 3773 - 3782. [Abstract] [Full Text] [PDF]
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L. L. Pewe, J. M. Netland, S. B. Heard, and S. Perlman Very Diverse CD8 T Cell Clonotypic Responses after Virus Infections J. Immunol., March 1, 2004; 172(5): 3151 - 3156. [Abstract] [Full Text] [PDF]
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Z. Kurepa, J. Su, and J. Forman Memory Phenotype of CD8+ T Cells in MHC Class Ia-Deficient Mice J. Immunol., June 1, 2003; 170(11): 5414 - 5420. [Abstract] [Full Text] [PDF]
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A. Boissonnas, O. Bonduelle, A. Antzack, Y.-C. Lone, C. Gache, P. Debre, B. Autran, and B. Combadiere In Vivo Priming Of HIV-Specific CTLs Determines Selective Cross-Reactive Immune Responses Against Poorly Immunogenic HIV-Natural Variants J. Immunol., October 1, 2002; 169(7): 3694 - 3699. [Abstract] [Full Text] [PDF]
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