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*
Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029; and
Department of Environmental Health Sciences, Johns Hopkins University School of Hygiene and Public Health, Baltimore, MD 21205
CpG oligodeoxynucleotides (CpG-ODN) administered during Ag
sensitization or before Ag challenge can inhibit allergic pulmonary
inflammation and airway hyperreactivity in murine models of asthma. In
this study, we investigated whether CpG-ODN can reverse an ongoing
allergic pulmonary reaction in a mouse model of asthma. AKR mice were
sensitized with conalbumin followed by two intratracheal challenges at
weekly intervals. CpG-ODN was administered 24 h after the first Ag
challenge. CpG-ODN administration reduced Ag-specific IgE levels,
bronchoalveolar lavage fluid eosinophils, mucus production, and airway
hyperreactivity. We found that postchallenge CpG-ODN treatment
significantly increased IFN-
concentrations and decreased IL-13,
IL-4, and IL-5 concentrations in bronchoalveolar lavage fluids and
spleen cell culture supernatants. Postchallenge CpG-ODN treatment also
increased B7.1 mRNA expression and decreased B7.2 mRNA expression in
lung tissues. These results suggest that CpG-ODN may have potential for
treatment of allergic asthma by suppressing Th2 responses during
IgE-dependent allergic airway reactions. The down-regulation of Th2
responses by CPG-ODN may be associated with regulation of the
costimulatory factors B7.1 and B7.2.
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