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Chemokine from Mesothelial Cells1
*
Department of Pathophysiology, University Medical School, Poznan, Poland;
Department of Nephrology and Medical Intensive Care, Universitätsklinikum Charité, Campus Virchow-Klinikum, Humboldt-Universität zu Berlin, Berlin, Germany; and
Department of Visceral and Transplant Surgery, University of Bern, Inselspital, Bern, Switzerland
IL-17 is a newly discovered cytokine implicated in the regulation
of hemopoiesis and inflammation. Because IL-17 production is restricted
to activated T lymphocytes, the effects exerted by IL-17 may help one
to understand the contribution of T cells to the inflammatory response.
We investigated the role of IL-17 in leukocyte recruitment into the
peritoneal cavity. Leukocyte infiltration in vivo was assessed in
BALB/Cj mice. Effects of IL-17 on chemokine generation in vitro were
examined in human peritoneal mesothelial cells (HPMC). Administration
of IL-17 i.p. resulted in a selective recruitment of neutrophils into
the peritoneum and increased levels of KC chemokine (murine homologue
of human growth-related oncogene 
(GRO). Pretreatment with
anti-KC Ab significantly reduced the IL-17-driven neutrophil
accumulation. Primary cultures of HPMC expressed IL-17 receptor mRNA.
Exposure of HPMC to IL-17 led to a dose- and time-dependent induction
of GRO mRNA and protein. Combination of IL-17 together with TNF-
resulted in an increased stability of GRO mRNA and synergistic
release of GRO protein. Anti-IL-17 Ab blocked the effects of IL-17
in vitro and in vivo. IL-17 is capable of selectively recruiting
neutrophils into the peritoneal cavity via the release of
neutrophil-specific chemokines from the peritoneal
mesothelium.
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