| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Immunology, University of Washington, Seattle, WA 98195
Fas ligand (FasL/CD95L/APO-1L) is one of a growing number of TNF family members whose triggering costimulates maximal proliferation of activated T cells. In this study we show that maximal Ag-dependent accumulation of transferred TCR-transgenic CD8+ T cells requires Fas (CD95/APO-1) expression by the adoptive hosts. Additionally, adoptively transferred FasL+ CD8+ T cells demonstrate a 2-fold advantage in Ag-driven expansion over their FasL-counterparts. This study illustrates the in vivo role of TCR-dependent FasL costimulation in the Ag-specific proliferation of both heterogeneous and homogeneous populations of primary CD8+ T cells and long-term CTL lines. Thus, cross-linking FasL on naive and Ag-experienced CD8+ T cells whose Ag-specific TCRs are engaged is required to drive maximal cellular proliferation in vivo.
This article has been cited by other articles:
|
|
 |
|
  M. Paulsen, B. Mathew, J. Qian, M. Lettau, D. Kabelitz, and O. Janssen FasL cross-linking inhibits activation of human peripheral T cells Int. Immunol., May 1, 2009; 21(5): 587 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Makaroff, D. W. Hendricks, R. E. Niec, and P. J. Fink Postthymic maturation influences the CD8 T cell response to antigen PNAS, March 24, 2009; 106(12): 4799 - 4804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. R. Olson and S. M. Varga Fas Ligand Is Required for the Development of Respiratory Syncytial Virus Vaccine-Enhanced Disease J. Immunol., March 1, 2009; 182(5): 3024 - 3031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Puliaeva, R. Puliaev, A. Shustov, M. Haas, and C. S. Via Fas Expression on Antigen-Specific T Cells Has Costimulatory, Helper, and Down-Regulatory Functions In Vivo for Cytotoxic T Cell Responses but Not for T Cell-Dependent B Cell Responses J. Immunol., November 1, 2008; 181(9): 5912 - 5929. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Kavurma, N. Y. Tan, and M. R. Bennett Death Receptors and Their Ligands in Atherosclerosis Arterioscler. Thromb. Vasc. Biol., October 1, 2008; 28(10): 1694 - 1702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Loeffler, G. Le'Negrate, M. Krajewska, and J. C. Reed Inhibition of Tumor Growth Using Salmonella Expressing Fas Ligand J Natl Cancer Inst, August 6, 2008; 100(15): 1113 - 1116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Dudani, M. Russell, H. van Faassen, L. Krishnan, and S. Sad Mutation in the Fas Pathway Impairs CD8+ T Cell Memory J. Immunol., March 1, 2008; 180(5): 2933 - 2941. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sun, S. Lee, S. Karray, M. Levi-Strauss, K. T. Ames, and P. J. Fink Cutting Edge: Two Distinct Motifs within the Fas Ligand Tail Regulate Fas Ligand-Mediated Costimulation J. Immunol., November 1, 2007; 179(9): 5639 - 5643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sun and P. J. Fink A New Class of Reverse Signaling Costimulators Belongs to the TNF Family J. Immunol., October 1, 2007; 179(7): 4307 - 4312. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Sun, K. T. Ames, I. Suzuki, and P. J. Fink The Cytoplasmic Domain of Fas Ligand Costimulates TCR Signals J. Immunol., August 1, 2006; 177(3): 1481 - 1491. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Mohamood, C. J. Trujillo, D. Zheng, C. Jie, F. M. Murillo, J. P. Schneck, and A. R. A. Hamad Gld mutation of Fas ligand increases the frequency and up-regulates cell survival genes in CD25+CD4+ TR cells Int. Immunol., August 1, 2006; 18(8): 1265 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Hale, T. E. Boursalian, G. L. Turk, and P. J. Fink Thymic output in aged mice PNAS, May 30, 2006; 103(22): 8447 - 8452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Cahuzac, W. Baum, V. Kirkin, F. Conchonaud, L. Wawrezinieck, D. Marguet, O. Janssen, M. Zornig, and A.-O. Hueber Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activity Blood, March 15, 2006; 107(6): 2384 - 2391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Shi, J. Wolfe, J. Q. Russell, K. Fortner, N. Hardin, J. Anguita, and R. C. Budd Fas Ligand Deficiency Impairs Host Inflammatory Response against Infection with the Spirochete Borrelia burgdorferi Infect. Immun., February 1, 2006; 74(2): 1156 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Baum, V. Kirkin, S. B. M. Fernandez, R. Pick, M. Lettau, O. Janssen, and M. Zornig Binding of the Intracellular Fas Ligand (FasL) Domain to the Adaptor Protein PSTPIP Results in a Cytoplasmic Localization of FasL J. Biol. Chem., December 2, 2005; 280(48): 40012 - 40024. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Valerie Pasqualetto, Florence Vasseur, Flora Zavala, Elke Schneider, and Sophie Ezine Fas receptor signaling is requisite for B cell differentiation J. Leukoc. Biol., November 1, 2005; 78(5): 1106 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Shi, J. Mao, G. Yu, J. Zhang, and J. Wu Tumor Vaccine Based on Cell Surface Expression of DcR3/TR6 J. Immunol., April 15, 2005; 174(8): 4727 - 4735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-R. Yang, S.-L. Hsieh, F.-M. Ho, and W.-W. Lin Decoy Receptor 3 Increases Monocyte Adhesion to Endothelial Cells via NF-{kappa}B-Dependent Up-Regulation of Intercellular Adhesion Molecule-1, VCAM-1, and IL-8 Expression J. Immunol., February 1, 2005; 174(3): 1647 - 1656. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cippitelli, C. Fionda, D. Di Bona, M. Piccoli, L. Frati, and A. Santoni Hyperthermia Enhances CD95-Ligand Gene Expression in T Lymphocytes J. Immunol., January 1, 2005; 174(1): 223 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. F. Martin, J. C. Dudda, V. Delattre, E. Bachtanian, C. Leicht, B. Burger, H. U. Weltzien, and J. C. Simon Fas-Mediated Inhibition of CD4+ T Cell Priming Results in Dominance of Type 1 CD8+ T Cells in the Immune Response to the Contact Sensitizer Trinitrophenyl J. Immunol., September 1, 2004; 173(5): 3178 - 3185. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Rutigliano and B. S. Graham Prolonged Production of TNF-{alpha} Exacerbates Illness during Respiratory Syncytial Virus Infection J. Immunol., September 1, 2004; 173(5): 3408 - 3417. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Mikolajczak, B. Y. Ma, T. Yoshida, R. Yoshida, D. J. Kelvin, and A. Ochi The Modulation of CD40 Ligand Signaling by Transmembrane CD28 Splice Variant in Human T Cells J. Exp. Med., April 5, 2004; 199(7): 1025 - 1031. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Guo, M. Zhang, H. An, W. Chen, S. Liu, J. Guo, Y. Yu, and X. Cao Fas ligation induces IL-1{beta}-dependent maturation and IL-1{beta}-independent survival of dendritic cells: different roles of ERK and NF-{kappa}B signaling pathways Blood, December 15, 2003; 102(13): 4441 - 4447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. V. Proussakova, N. A. Rabaya, A. B. Moshnikova, E. S. Telegina, A. Turanov, M. G. Nanazashvili, and I. P. Beletsky Oligomerization of Soluble Fas Antigen Induces Its Cytotoxicity J. Biol. Chem., September 19, 2003; 278(38): 36236 - 36241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. E. Boursalian and P. J. Fink Mutation in Fas Ligand Impairs Maturation of Thymocytes Bearing Moderate Affinity T Cell Receptors J. Exp. Med., July 21, 2003; 198(2): 349 - 360. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Beisner, I. H. Chu, A. F. Arechiga, S. M. Hedrick, and C. M. Walsh The Requirements for Fas-Associated Death Domain Signaling in Mature T Cell Activation and Survival J. Immunol., July 1, 2003; 171(1): 247 - 256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cippitelli, C. Fionda, D. Di Bona, A. Lupo, M. Piccoli, L. Frati, and A. Santoni The Cyclopentenone-Type Prostaglandin 15-Deoxy-{Delta}12,14-Prostaglandin J2 Inhibits CD95 Ligand Gene Expression in T Lymphocytes: Interference with Promoter Activation Via Peroxisome Proliferator-Activated Receptor-{gamma}-Independent Mechanisms J. Immunol., May 1, 2003; 170(9): 4578 - 4592. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kasahara, K. Ando, K. Saito, K. Sekikawa, H. Ito, T. Ishikawa, H. Ohnishi, M. Seishima, S. Kakumu, and H. Moriwaki Lack of Tumor Necrosis Factor Alpha Induces Impaired Proliferation of Hepatitis B Virus-Specific Cytotoxic T Lymphocytes J. Virol., February 15, 2003; 77(4): 2469 - 2476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wan, J. Zhang, H. Luo, G. Shi, E. Kapnik, S. Kim, P. Kanakaraj, and J. Wu A TNF Family Member LIGHT Transduces Costimulatory Signals into Human T Cells J. Immunol., December 15, 2002; 169(12): 6813 - 6821. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Shi, H. Luo, X. Wan, T. W. Salcedo, J. Zhang, and J. Wu Mouse T cells receive costimulatory signals from LIGHT, a TNF family member Blood, October 16, 2002; 100(9): 3279 - 3286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Surquin, A. Le Moine, V. Flamand, N. Nagy, K. Rombaut, F.-X. Demoor, P. Stordeur, I. Salmon, J.-C. Guery, M. Goldman, et al. Skin Graft Rejection Elicited by {beta}2-Microglobulin as a Minor Transplantation Antigen Involves Multiple Effector Pathways: Role of Fas-Fas Ligand Interactions and Th2-Dependent Graft Eosinophil Infiltrates J. Immunol., July 1, 2002; 169(1): 500 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T.-L. Hsu, Y.-C. Chang, S.-J. Chen, Y.-J. Liu, A. W. Chiu, C.-C. Chio, L. Chen, and S.-L. Hsieh Modulation of Dendritic Cell Differentiation and Maturation by Decoy Receptor 3 J. Immunol., May 15, 2002; 168(10): 4846 - 4853. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Seko, N. Kayagaki, K.-i. Seino, H. Yagita, K. Okumura, and R. Nagai Role of Fas/FasL pathway in the activation of infiltrating cells in murine acute myocarditis caused by Coxsackievirus B3 J. Am. Coll. Cardiol., April 17, 2002; 39(8): 1399 - 1403. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Cippitelli, C. Fionda, D. Di Bona, F. Di Rosa, A. Lupo, M. Piccoli, L. Frati, and A. Santoni Negative Regulation of CD95 Ligand Gene Expression by Vitamin D3 in T Lymphocytes J. Immunol., February 1, 2002; 168(3): 1154 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. C. G. Marcondes, E. M. E. Burudi, S. Huitron-Resendiz, M. Sanchez-Alavez, D. Watry, M. Zandonatti, S. J. Henriksen, and H. S. Fox Highly Activated CD8+ T Cells in the Brain Correlate with Early Central Nervous System Dysfunction in Simian Immunodeficiency Virus Infection J. Immunol., November 1, 2001; 167(9): 5429 - 5438. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Kafrouni, G. R. Brown, and D. L. Thiele Virally Infected Hepatocytes Are Resistant to Perforin-Dependent CTL Effector Mechanisms J. Immunol., August 1, 2001; 167(3): 1566 - 1574. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
