The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takeuchi, O.
Right arrow Articles by Akira, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takeuchi, O.
Right arrow Articles by Akira, S.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*OMIM
*UniGene
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Staphylococcal Infections
The Journal of Immunology, 2000, 165: 5392-5396.
Copyright © 2000 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to Staphylococcus aureus Infection1

Osamu Takeuchi*,{dagger}, Katsuaki Hoshino*,{dagger} and Shizuo Akira2,*,{dagger}

* Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan; and {dagger} Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Osaka, Japan

Toll-like receptor (TLR) family acts as pattern recognition receptors for pathogen-specific molecular patterns. We previously showed that TLR2 recognizes Gram-positive bacterial components whereas TLR4 recognizes LPS, a component of Gram-negative bacteria. MyD88 is shown to be an adaptor molecule essential for TLR family signaling. To investigate the role of TLR family in host defense against Gram-positive bacteria, we infected TLR2- and MyD88-deficient mice with Staphylococcus aureus. Both TLR2- and MyD88-deficient mice were highly susceptible to S. aureus infection, with more enhanced susceptibility in MyD88-deficient mice. Peritoneal macrophages from MyD88-deficient mice did not produce any detectable levels of cytokines in response to S. aureus. In contrast, TLR2-deficient macrophages produced reduced, but significant, levels of the cytokines, and TLR4-deficient macrophages produced the same amounts as wild-type cells, indicating that S. aureus is recognized not only by TLR2, but also by other TLR family members except for TLR4.




This article has been cited by other articles:


Home page
 Infect. Immun.Home page
B. B. Mishra, U. M. Gundra, K. Wong, and J. M. Teale
MyD88-Deficient Mice Exhibit Decreased Parasite-Induced Immune Responses but Reduced Disease Severity in a Murine Model of Neurocysticercosis
Infect. Immun., December 1, 2009; 77(12): 5369 - 5379.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Sasaki, M. Ogasawara, T. Sekiguchi, S. Kusumoto, and H. Satake
Toll-like Receptors of the Ascidian Ciona intestinalis: PROTOTYPES WITH HYBRID FUNCTIONALITIES OF VERTEBRATE TOLL-LIKE RECEPTORS
J. Biol. Chem., October 2, 2009; 284(40): 27336 - 27343.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. Munoz-Planillo, L. Franchi, L. S. Miller, and G. Nunez
A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome
J. Immunol., September 15, 2009; 183(6): 3942 - 3948.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y.-L. Cheng, C.-Y. Wang, W.-C. Huang, C.-C. Tsai, C.-L. Chen, C.-F. Shen, C.-Y. Chi, and C.-F. Lin
Staphylococcus aureus Induces Microglial Inflammation via a Glycogen Synthase Kinase 3{beta}-Regulated Pathway
Infect. Immun., September 1, 2009; 77(9): 4002 - 4008.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
Y.-C. Chang, W.-C. Kao, W.-Y. Wang, W.-Y. Wang, R.-B. Yang, and K. Peck
Identification and characterization of oligonucleotides that inhibit Toll-like receptor 2-associated immune responses
FASEB J, September 1, 2009; 23(9): 3078 - 3088.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Chamorro, J. J. Garcia-Vallejo, W. W. J. Unger, R. J. Fernandes, S. C. M. Bruijns, S. Laban, B. O. Roep, B. A. 't Hart, and Y. van Kooyk
TLR Triggering on Tolerogenic Dendritic Cells Results in TLR2 Up-Regulation and a Reduced Proinflammatory Immune Program
J. Immunol., September 1, 2009; 183(5): 2984 - 2994.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Chassin, M. Picardeau, J.-M. Goujon, P. Bourhy, N. Quellard, S. Darche, E. Badell, M. F. d'Andon, N. Winter, S. Lacroix-Lamande, et al.
TLR4- and TLR2-Mediated B Cell Responses Control the Clearance of the Bacterial Pathogen, Leptospira interrogans
J. Immunol., August 15, 2009; 183(4): 2669 - 2677.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
P. Hruz, A. S. Zinkernagel, G. Jenikova, G. J. Botwin, J.-P. Hugot, M. Karin, V. Nizet, and L. Eckmann
NOD2 contributes to cutaneous defense against Staphylococcus aureus through {alpha}-toxin-dependent innate immune activation
PNAS, August 4, 2009; 106(31): 12873 - 12878.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
E. Slack, S. Hapfelmeier, B. Stecher, Y. Velykoredko, M. Stoel, M. A. E. Lawson, M. B. Geuking, B. Beutler, T. F. Tedder, W.-D. Hardt, et al.
Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism
Science, July 31, 2009; 325(5940): 617 - 620.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
F. Han, H. Yu, C. Tian, S. Li, M. R. Jacobs, C. Benedict-Alderfer, and Q. Y. Zheng
Role for Toll-Like Receptor 2 in the Immune Response to Streptococcus pneumoniae Infection in Mouse Otitis Media
Infect. Immun., July 1, 2009; 77(7): 3100 - 3108.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
Y. Minegishi, M. Saito, M. Nagasawa, H. Takada, T. Hara, S. Tsuchiya, K. Agematsu, M. Yamada, N. Kawamura, T. Ariga, et al.
Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome
J. Exp. Med., June 8, 2009; 206(6): 1291 - 1301.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Kenzel, S. Santos-Sierra, S. D. Deshmukh, I. Moeller, B. Ergin, K. A. Fitzgerald, E. Lien, S. Akira, D. T. Golenbock, and P. Henneke
Role of p38 and Early Growth Response Factor 1 in the Macrophage Response to Group B Streptococcus
Infect. Immun., June 1, 2009; 77(6): 2474 - 2481.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Schmaler, N. J. Jann, F. Ferracin, L. Z. Landolt, L. Biswas, F. Gotz, and R. Landmann
Lipoproteins in Staphylococcus aureus Mediate Inflammation by TLR2 and Iron-Dependent Growth In Vivo
J. Immunol., June 1, 2009; 182(11): 7110 - 7118.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. R. Nichols, A. L. Aldrich, M. M. Mariani, D. Vidlak, N. Esen, and T. Kielian
TLR2 Deficiency Leads to Increased Th17 Infiltrates in Experimental Brain Abscesses
J. Immunol., June 1, 2009; 182(11): 7119 - 7130.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
L. A. J. O'Neill, C. E. Bryant, and S. L. Doyle
Therapeutic Targeting of Toll-Like Receptors for Infectious and Inflammatory Diseases and Cancer
Pharmacol. Rev., June 1, 2009; 61(2): 177 - 197.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
T. H. Mogensen
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
Clin. Microbiol. Rev., April 1, 2009; 22(2): 240 - 273.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. Puliti, S. Uematsu, S. Akira, F. Bistoni, and L. Tissi
Toll-Like Receptor 2 Deficiency Is Associated with Enhanced Severity of Group B Streptococcal Disease
Infect. Immun., April 1, 2009; 77(4): 1524 - 1531.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
E. Amiel, A. Alonso, S. Uematsu, S. Akira, M. E. Poynter, and B. Berwin
Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis
J. Leukoc. Biol., April 1, 2009; 85(4): 595 - 605.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. Kurokawa, H. Lee, K.-B. Roh, M. Asanuma, Y. S. Kim, H. Nakayama, A. Shiratsuchi, Y. Choi, O. Takeuchi, H. J. Kang, et al.
The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2
J. Biol. Chem., March 27, 2009; 284(13): 8406 - 8411.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. C. Alves-Filho, A. Freitas, F. O. Souto, F. Spiller, H. Paula-Neto, J. S. Silva, R. T. Gazzinelli, M. M. Teixeira, S. H. Ferreira, and F. Q. Cunha
Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis
PNAS, March 10, 2009; 106(10): 4018 - 4023.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Roger, C. Froidevaux, D. Le Roy, M. K. Reymond, A.-L. Chanson, D. Mauri, K. Burns, B. M. Riederer, S. Akira, and T. Calandra
Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4
PNAS, February 17, 2009; 106(7): 2348 - 2352.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. N. Sorensen, L. S. Reinert, L. Malmgaard, C. Bartholdy, A. R. Thomsen, and S. R. Paludan
TLR2 and TLR9 Synergistically Control Herpes Simplex Virus Infection in the Brain
J. Immunol., December 15, 2008; 181(12): 8604 - 8612.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. M. Rocha-de-Souza, B. Berent-Maoz, D. Mankuta, A. E. Moses, and F. Levi-Schaffer
Human Mast Cell Activation by Staphylococcus aureus: Interleukin-8 and Tumor Necrosis Factor Alpha Release and the Role of Toll-Like Receptor 2 and CD48 Molecules
Infect. Immun., October 1, 2008; 76(10): 4489 - 4497.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
M. Miettinen, V. Veckman, S. Latvala, T. Sareneva, S. Matikainen, and I. Julkunen
Live Lactobacillus rhamnosus and Streptococcus pyogenes differentially regulate Toll-like receptor (TLR) gene expression in human primary macrophages
J. Leukoc. Biol., October 1, 2008; 84(4): 1092 - 1100.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
W. Sukhumavasi, C. E. Egan, A. L. Warren, G. A. Taylor, B. A. Fox, D. J. Bzik, and E. Y. Denkers
TLR Adaptor MyD88 Is Essential for Pathogen Control during Oral Toxoplasma gondii Infection but Not Adaptive Immunity Induced by a Vaccine Strain of the Parasite
J. Immunol., September 1, 2008; 181(5): 3464 - 3473.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. Hussain, N. Nasreen, Y. Lai, B. F. Bellew, V. B. Antony, and K. A. Mohammed
Innate immune responses in murine pleural mesothelial cells: Toll-like receptor-2 dependent induction of {beta}-defensin-2 by staphylococcal peptidoglycan
Am J Physiol Lung Cell Mol Physiol, September 1, 2008; 295(3): L461 - L470.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
H. von Bernuth, C. Picard, Z. Jin, R. Pankla, H. Xiao, C.-L. Ku, M. Chrabieh, I. B. Mustapha, P. Ghandil, Y. Camcioglu, et al.
Pyogenic Bacterial Infections in Humans with MyD88 Deficiency
Science, August 1, 2008; 321(5889): 691 - 696.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Piccini, S. Carta, S. Tassi, D. Lasiglie, G. Fossati, and A. Rubartelli
ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1{beta} and IL-18 secretion in an autocrine way
PNAS, June 10, 2008; 105(23): 8067 - 8072.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
O. S. Shin, R. R. Isberg, S. Akira, S. Uematsu, A. K. Behera, and L. T. Hu
Distinct Roles for MyD88 and Toll-Like Receptors 2, 5, and 9 in Phagocytosis of Borrelia burgdorferi and Cytokine Induction
Infect. Immun., June 1, 2008; 76(6): 2341 - 2351.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. Pang, D. Winn, R. Johnson, W. Hong, S. West-Barnette, N. Kock, and W. E. Swords
Lipooligosaccharides Containing Phosphorylcholine Delay Pulmonary Clearance of Nontypeable Haemophilus influenzae
Infect. Immun., May 1, 2008; 76(5): 2037 - 2043.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. C. Nance, A.-K. Yi, F. C. Re, and E. A. Fitzpatrick
MyD88 is necessary for neutrophil recruitment in hypersensitivity pneumonitis
J. Leukoc. Biol., May 1, 2008; 83(5): 1207 - 1217.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Lampropoulou, K. Hoehlig, T. Roch, P. Neves, E. C. Gomez, C. H. Sweenie, Y. Hao, A. A. Freitas, U. Steinhoff, S. M. Anderton, et al.
TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity
J. Immunol., April 1, 2008; 180(7): 4763 - 4773.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Leendertse, R. J. L. Willems, I. A. J. Giebelen, P. S. van den Pangaart, W. J. Wiersinga, A. F. de Vos, S. Florquin, M. J. M. Bonten, and T. van der Poll
TLR2-Dependent MyD88 Signaling Contributes to Early Host Defense in Murine Enterococcus faecium Peritonitis
J. Immunol., April 1, 2008; 180(7): 4865 - 4874.
[Abstract] [Full Text] [PDF]

Home page
 Reproductive SciencesHome page
K. Koga and G. Mor
Review Article: Expression and Function of Toll-Like Receptors at the Maternal--Fetal Interface
Reproductive Sciences, March 1, 2008; 15(3): 231 - 242.
[Abstract] [PDF]

Home page
 JEMHome page
W.K. E. Ip, K. Takahashi, K. J. Moore, L. M. Stuart, and R. A. B. Ezekowitz
Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome
J. Exp. Med., January 21, 2008; 205(1): 169 - 181.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H. S. Seo, S. M. Michalek, and M. H. Nahm
Lipoteichoic Acid Is Important in Innate Immune Responses to Gram-Positive Bacteria
Infect. Immun., January 1, 2008; 76(1): 206 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
W. Stenzel, S. Soltek, M. Sanchez-Ruiz, S. Akira, H. Miletic, D. Schluter, and M. Deckert
Both TLR2 and TLR4 Are Required for the Effective Immune Response in Staphylococcus aureus-Induced Experimental Murine Brain Abscess
Am. J. Pathol., January 1, 2008; 172(1): 132 - 145.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. E. Wisse, K. Ogimoto, J. Tang, M. K. Harris Jr., E. W. Raines, and M. W. Schwartz
Evidence that Lipopolysaccharide-Induced Anorexia Depends upon Central, Rather than Peripheral, Inflammatory Signals
Endocrinology, November 1, 2007; 148(11): 5230 - 5237.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
D. W. Haden, H. B. Suliman, M. S. Carraway, K. E. Welty-Wolf, A. S. Ali, H. Shitara, H. Yonekawa, and C. A. Piantadosi
Mitochondrial Biogenesis Restores Oxidative Metabolism during Staphylococcus aureus Sepsis
Am. J. Respir. Crit. Care Med., October 15, 2007; 176(8): 768 - 777.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
C.-L. Ku, H. von Bernuth, C. Picard, S.-Y. Zhang, H.-H. Chang, K. Yang, M. Chrabieh, A. C. Issekutz, C. K. Cunningham, J. Gallin, et al.
Selective predisposition to bacterial infections in IRAK-4 deficient children: IRAK-4 dependent TLRs are otherwise redundant in protective immunity
J. Exp. Med., October 1, 2007; 204(10): 2407 - 2422.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. Csoka, Z. H. Nemeth, L. Virag, P. Gergely, S. J. Leibovich, P. Pacher, C.-X. Sun, M. R. Blackburn, E. S. Vizi, E. A. Deitch, et al.
A2A adenosine receptors and C/EBP{beta} are crucially required for IL-10 production by macrophages exposed to Escherichia coli
Blood, October 1, 2007; 110(7): 2685 - 2695.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. E. Cole, K. A. Shirey, E. Barry, A. Santiago, P. Rallabhandi, K. L. Elkins, A. C. Puche, S. M. Michalek, and S. N. Vogel
Toll-Like Receptor 2-Mediated Signaling Requirements for Francisella tularensis Live Vaccine Strain Infection of Murine Macrophages
Infect. Immun., August 1, 2007; 75(8): 4127 - 4137.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
V. Auerbuch and R. R. Isberg
Growth of Yersinia pseudotuberculosis in Mice Occurs Independently of Toll-Like Receptor 2 Expression and Induction of Interleukin-10
Infect. Immun., July 1, 2007; 75(7): 3561 - 3570.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Genestier, M. Taillardet, P. Mondiere, H. Gheit, C. Bella, and T. Defrance
TLR Agonists Selectively Promote Terminal Plasma Cell Differentiation of B Cell Subsets Specialized in Thymus-Independent Responses
J. Immunol., June 15, 2007; 178(12): 7779 - 7786.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Kim, M. A. Kim, I.-H. Cho, M. S. Kim, S. Lee, E.-K. Jo, S.-Y. Choi, K. Park, J. S. Kim, S. Akira, et al.
A Critical Role of Toll-like Receptor 2 in Nerve Injury-induced Spinal Cord Glial Cell Activation and Pain Hypersensitivity
J. Biol. Chem., May 18, 2007; 282(20): 14975 - 14983.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
O. Hoffmann, J. S. Braun, D. Becker, A. Halle, D. Freyer, E. Dagand, S. Lehnardt, and J. R. Weber
TLR2 Mediates Neuroinflammation and Neuronal Damage
J. Immunol., May 15, 2007; 178(10): 6476 - 6481.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
N. Chaudhuri, M. K. B. Whyte, and I. Sabroe
Reducing the Toll of Inflammatory Lung Disease
Chest, May 1, 2007; 131(5): 1550 - 1556.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
M. C. Dessing, K. F. van der Sluijs, S. Florquin, S. Akira, and T. van der Poll
Toll-Like Receptor 2 Does Not Contribute to Host Response during Postinfluenza Pneumococcal Pneumonia
Am. J. Respir. Cell Mol. Biol., May 1, 2007; 36(5): 609 - 614.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. KuoLee, X. Zhao, J. Austin, G. Harris, J. W. Conlan, and W. Chen
Mouse Model of Oral Infection with Virulent Type A Francisella tularensis
Infect. Immun., April 1, 2007; 75(4): 1651 - 1660.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Nakayama, D. M. Underhill, T. W. Petersen, B. Li, T. Kitamura, T. Takai, and A. Aderem
Paired Ig-Like Receptors Bind to Bacteria and Shape TLR-Mediated Cytokine Production
J. Immunol., April 1, 2007; 178(7): 4250 - 4259.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Kielian, N. K. Phulwani, N. Esen, M. Md. Syed, A. C. Haney, K. McCastlain, and J. Johnson
MyD88-Dependent Signals Are Essential for the Host Immune Response in Experimental Brain Abscess
J. Immunol., April 1, 2007; 178(7): 4528 - 4537.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. Kapetanovic, M.-A. Nahori, V. Balloy, C. Fitting, D. J. Philpott, J.-M. Cavaillon, and M. Adib-Conquy
Contribution of Phagocytosis and Intracellular Sensing for Cytokine Production by Staphylococcus aureus-Activated Macrophages
Infect. Immun., February 1, 2007; 75(2): 830 - 837.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
F. Cao, A. Castrillo, P. Tontonoz, F. Re, and G. I. Byrne
Chlamydia pneumoniae-Induced Macrophage Foam Cell Formation Is Mediated by Toll-Like Receptor 2
Infect. Immun., February 1, 2007; 75(2): 753 - 759.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. J. Skerrett, C. B. Wilson, H. D. Liggitt, and A. M. Hajjar
Redundant Toll-like receptor signaling in the pulmonary host response to Pseudomonas aeruginosa
Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L312 - L322.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. S. Hardarson, J. S. Baker, Z. Yang, E. Purevjav, C.-H. Huang, L. Alexopoulou, N. Li, R. A. Flavell, N. E. Bowles, and J. G. Vallejo
Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury
Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H251 - H258.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Burns, G. Bachrach, L. Shapira, and G. Nussbaum
Cutting Edge: TLR2 Is Required for the Innate Response to Porphyromonas gingivalis: Activation Leads to Bacterial Persistence and TLR2 Deficiency Attenuates Induced Alveolar Bone Resorption
J. Immunol., December 15, 2006; 177(12): 8296 - 8300.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. D. Bolz, R. S. Sundsbak, Y. Ma, S. Akira, J. H. Weis, T. G. Schwan, and J. J. Weis
Dual Role of MyD88 in Rapid Clearance of Relapsing Fever Borrelia spp.
Infect. Immun., December 1, 2006; 74(12): 6750 - 6760.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Flacher, M. Bouschbacher, E. Verronese, C. Massacrier, V. Sisirak, O. Berthier-Vergnes, B. de Saint-Vis, C. Caux, C. Dezutter-Dambuyant, S. Lebecque, et al.
Human Langerhans Cells Express a Specific TLR Profile and Differentially Respond to Viruses and Gram-Positive Bacteria
J. Immunol., December 1, 2006; 177(11): 7959 - 7967.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. C. Mullaly and P. Kubes
The Role of TLR2 In Vivo following Challenge with Staphylococcus aureus and Prototypic Ligands
J. Immunol., December 1, 2006; 177(11): 8154 - 8163.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. M. Buckley, J. H. Wang, and H. P. Redmond
Cellular reprogramming by gram-positive bacterial components: a review
J. Leukoc. Biol., October 1, 2006; 80(4): 731 - 741.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Bubeck Wardenburg, W. A. Williams, and D. Missiakas
Host defenses against Staphylococcus aureus infection require recognition of bacterial lipoproteins
PNAS, September 12, 2006; 103(37): 13831 - 13836.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
Y. Sun, A. G. Hise, C. M. Kalsow, and E. Pearlman
Staphylococcus aureus-Induced Corneal Inflammation Is Dependent on Toll-Like Receptor 2 and Myeloid Differentiation Factor 88
Infect. Immun., September 1, 2006; 74(9): 5325 - 5332.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Mikami, J. H. Lim, H. Ishinaga, U.-H. Ha, H. Gu, T. Koga, H. Jono, H. Kai, and J.-D. Li
The Transforming Growth Factor-beta-Smad3/4 Signaling Pathway Acts as a Positive Regulator for TLR2 Induction by Bacteria via a Dual Mechanism Involving Functional Cooperation with NF-{kappa}B and MAPK Phosphatase 1-dependent Negative Cross-talk with p38 MAPK
J. Biol. Chem., August 4, 2006; 281(31): 22397 - 22408.
[Abstract] [Full Text] [PDF]

Home page
 J BiochemHome page
T. Tsukuba, S. Yamamoto, M. Yanagawa, K. Okamoto, Y. Okamoto, K. I. Nakayama, T. Kadowaki, and K. Yamamoto
Cathepsin e-deficient mice show increased susceptibility to bacterial infection associated with the decreased expression of multiple cell surface toll-like receptors.
J. Biochem., July 1, 2006; 140(1): 57 - 66.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. A. Archer and C. R. Roy
MyD88-Dependent Responses Involving Toll-Like Receptor 2 Are Important for Protection and Clearance of Legionella pneumophila in a Mouse Model of Legionnaires' Disease.
Infect. Immun., June 1, 2006; 74(6): 3325 - 3333.
[Abstract] [Full Text] [PDF]

Home page
 Arch SurgHome page
L. Romics Jr, G. Szabo, J. C. Coffey, J. H. Wang, and H. P. Redmond
The Emerging Role of Toll-Like Receptor Pathways in Surgical Diseases
Arch Surg, June 1, 2006; 141(6): 595 - 601.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Esen and T. Kielian
Central Role for MyD88 in the Responses of Microglia to Pathogen-Associated Molecular Patterns.
J. Immunol., June 1, 2006; 176(11): 6802 - 6811.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. Katz, P. Zhang, M. Martin, S. N. Vogel, and S. M. Michalek
Toll-Like Receptor 2 Is Required for Inflammatory Responses to Francisella tularensis LVS.
Infect. Immun., May 1, 2006; 74(5): 2809 - 2816.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
E. Szomolanyi-Tsuda, X. Liang, R. M. Welsh, E. A. Kurt-Jones, and R. W. Finberg
Role for TLR2 in NK Cell-Mediated Control of Murine Cytomegalovirus In Vivo
J. Virol., May 1, 2006; 80(9): 4286 - 4291.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. M. van der Sar, O. W. Stockhammer, C. van der Laan, H. P. Spaink, W. Bitter, and A. H. Meijer
MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model
Infect. Immun., April 1, 2006; 74(4): 2436 - 2441.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. Fan, Y. Li, Y. Vodovotz, T. R. Billiar, and M. A. Wilson
Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation
Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L738 - L746.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. K. Behera, E. Hildebrand, R. T. Bronson, G. Perides, S. Uematsu, S. Akira, and L. T. Hu
MyD88 Deficiency Results in Tissue-Specific Changes in Cytokine Induction and Inflammation in Interleukin-18-Independent Mice Infected with Borrelia burgdorferi
Infect. Immun., March 1, 2006; 74(3): 1462 - 1470.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
Y.-T.A. Teng
Protective and Destructive Immunity in the Periodontium: Part 1--Innate and Humoral Immunity and the Periodontium
Journal of Dental Research, March 1, 2006; 85(3): 198 - 208.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
S. Knapp, C. W. Wieland, S. Florquin, R. Pantophlet, L. Dijkshoorn, N. Tshimbalanga, S. Akira, and T. van der Poll
Differential Roles of CD14 and Toll-like Receptors 4and 2 in Murine Acinetobacter Pneumonia
Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 122 - 129.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Yoshida, H. Jono, H. Kai, and J.-D. Li
The Tumor Suppressor Cylindromatosis (CYLD) Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7
J. Biol. Chem., December 9, 2005; 280(49): 41111 - 41121.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. B. Su, P. B. Silver, R. S. Grajewski, R. K. Agarwal, J. Tang, C.-C. Chan, and R. R. Caspi
Essential Role of the MyD88 Pathway, but Nonessential Roles of TLRs 2, 4, and 9, in the Adjuvant Effect Promoting Th1-Mediated Autoimmunity
J. Immunol., November 15, 2005; 175(10): 6303 - 6310.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. Kielian, A. Haney, P. M. Mayes, S. Garg, and N. Esen
Toll-Like Receptor 2 Modulates the Proinflammatory Milieu in Staphylococcus aureus-Induced Brain Abscess
Infect. Immun., November 1, 2005; 73(11): 7428 - 7435.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
J. S. Hadley, J. E. Wang, S. J. Foster, C. Thiemermann, and C. J. Hinds
Peptidoglycan of Staphylococcus aureus Upregulates Monocyte Expression of CD14, Toll-Like Receptor 2 (TLR2), and TLR4 in Human Blood: Possible Implications for Priming of Lipopolysaccharide Signaling
Infect. Immun., November 1, 2005; 73(11): 7613 - 7619.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Mikami, H. Gu, H. Jono, A. Andalibi, H. Kai, and J.-D. Li
Epidermal Growth Factor Receptor Acts as a Negative Regulator for Bacterium Nontypeable Haemophilus influenzae-induced Toll-like Receptor 2 Expression via an Src-dependent p38 Mitogen-activated Protein Kinase Signaling Pathway
J. Biol. Chem., October 28, 2005; 280(43): 36185 - 36194.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
K. Fuse, G. Chan, Y. Liu, P. Gudgeon, M. Husain, M. Chen, W.-C. Yeh, S. Akira, and P. P. Liu
Myeloid Differentiation Factor-88 Plays a Crucial Role in the Pathogenesis of Coxsackievirus B3-Induced Myocarditis and Influences Type I Interferon Production
Circulation, October 11, 2005; 112(15): 2276 - 2285.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. G. Netea, J. W. M. Van der Meer, R. P. Sutmuller, G. J. Adema, and B.-J. Kullberg
From the Th1/Th2 Paradigm towards a Toll-Like Receptor/T-Helper Bias
Antimicrob. Agents Chemother., October 1, 2005; 49(10): 3991 - 3996.
[Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. Srivastava, P. Henneke, A. Visintin, S. C. Morse, V. Martin, C. Watkins, J. C. Paton, M. R. Wessels, D. T. Golenbock, and R. Malley
The Apoptotic Response to Pneumolysin Is Toll-Like Receptor 4 Dependent and Protects against Pneumococcal Disease
Infect. Immun., October 1, 2005; 73(10): 6479 - 6487.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
V. Balloy, M. Si-Tahar, O. Takeuchi, B. Philippe, M.-A. Nahori, M. Tanguy, M. Huerre, S. Akira, J.-P. Latge, and M. Chignard
Involvement of Toll-Like Receptor 2 in Experimental Invasive Pulmonary Aspergillosis
Infect. Immun., September 1, 2005; 73(9): 5420 - 5425.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Naiki, K. S. Michelsen, N. W. J. Schroder, R. Alsabeh, A. Slepenkin, W. Zhang, S. Chen, B. Wei, Y. Bulut, M. H. Wong, et al.
MyD88 Is Pivotal for the Early Inflammatory Response and Subsequent Bacterial Clearance and Survival in a Mouse Model of Chlamydia pneumoniae Pneumonia
J. Biol. Chem., August 12, 2005; 280(32): 29242 - 29249.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
H.-S. Mun, F. Aosai, K. Norose, L.-X. Piao, H. Fang, S. Akira, and A. Yano
Toll-Like Receptor 4 Mediates Tolerance in Macrophages Stimulated with Toxoplasma gondii-Derived Heat Shock Protein 70
Infect. Immun., August 1, 2005; 73(8): 4634 - 4642.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
H. Fan, B. Zingarelli, O. M. Peck, G. Teti, G. E. Tempel, P. V. Halushka, and J. A. Cook
Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric G{alpha}i proteins
Am J Physiol Cell Physiol, August 1, 2005; 289(2): C293 - C301.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
B. Fournier and D. J. Philpott
Recognition of Staphylococcus aureus by the Innate Immune System
Clin. Microbiol. Rev., July 1, 2005; 18(3): 521 - 540.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Omatsu, T. Iyoda, Y. Kimura, A. Maki, M. Ishimori, N. Toyama-Sorimachi, and K. Inaba
Development of Murine Plasmacytoid Dendritic Cells Defined by Increased Expression of an Inhibitory NK Receptor, Ly49Q
J. Immunol., June 1, 2005; 174(11): 6657 - 6662.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Henneke, S. Morath, S. Uematsu, S. Weichert, M. Pfitzenmaier, O. Takeuchi, A. Muller, C. Poyart, S. Akira, R. Berner, et al.
Role of Lipoteichoic Acid in the Phagocyte Response to Group B Streptococcus
J. Immunol., May 15, 2005; 174(10): 6449 - 6455.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. G. Netea, G. Ferwerda, D. J. de Jong, T. Jansen, L. Jacobs, M. Kramer, T. H. J. Naber, J. P. H. Drenth, S. E. Girardin{paragraph}, B. Jan Kullberg, et al.
Nucleotide-Binding Oligomerization Domain-2 Modulates Specific TLR Pathways for the Induction of Cytokine Release
J. Immunol., May 15, 2005; 174(10): 6518 - 6523.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. W. Chu, S. Jeyaseelan, J. G. Rino, D. R. Voelker, R. B. Wexler, K. Campbell, R. J. Harbeck, and R. J. Martin
TLR2 Signaling Is Critical for Mycoplasma pneumoniae-Induced Airway Mucin Expression
J. Immunol., May 1, 2005; 174(9): 5713 - 5719.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Rodriguez, F. Fend, L. Jennen, M. Schiemann, N. Wantia, C. U. P. da Costa, S. Durr, U. Heinzmann, H. Wagner, and T. Miethke
Polymorphonuclear Neutrophils Improve Replication of Chlamydia pneumoniae In Vivo upon MyD88-Dependent Attraction
J. Immunol., April 15, 2005; 174(8): 4836 - 4844.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
E. Lorenz, D. C. Chemotti, A. L. Jiang, and L. D. McDougal
Differential Involvement of Toll-Like Receptors 2 and 4 in the Host Response to Acute Respiratory Infections with Wild-Type and Mutant Haemophilus influenzae Strains
Infect. Immun., April 1, 2005; 73(4): 2075 - 2082.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. L. Kau, S. M. Martin, W. Lyon, E. Hayes, M. G. Caparon, and S. J. Hultgren
Enterococcus faecalis Tropism for the Kidneys in the Urinary Tract of C57BL/6J Mice
Infect. Immun., April 1, 2005; 73(4): 2461 - 2468.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. I Lancaster, Q. Khan, P. Drysdale, F. Wallace, A. E Jeukendrup, M. T Drayson, and M. Gleeson
The physiological regulation of toll-like receptor expression and function in humans
J. Physiol., March 15, 2005; 563(3): 945 - 955.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
B. Gonzalez-Zorn, J. P. M. Senna, L. Fiette, S. Shorte, A. Testard, M. Chignard, P. Courvalin, and C. Grillot-Courvalin
Bacterial and Host Factors Implicated in Nasal Carriage of Methicillin-Resistant Staphylococcus aureus in Mice
Infect. Immun., March 1, 2005; 73(3): 1847 - 1851.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
H. Bjorkbacka, K. A. Fitzgerald, F. Huet, X. Li, J. A. Gregory, M. A. Lee, C. M. Ordija, N. E. Dowley, D. T. Golenbock, and M. W. Freeman
The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades
Physiol Genomics, February 7, 2005; 19(3): 319 - 330.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.