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The Journal of Immunology, 2000, 165: 5387-5391.
Copyright © 2000 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: OFF Cycling of TNF Production by Antigen-Specific CD8+ T Cells Is Antigen Independent1

Vladimir P. Badovinac*, Gail A. Corbin* and John T. Harty2,*,{dagger}

* Department of Microbiology and {dagger} Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242

Although they are known for their capacity to kill infected cells, Ag-specific CD8+ T cells elaborate other effector mechanisms, including TNF and IFN-{gamma}, that contribute to defense against infection. Ag-specific CD8+ T cells rapidly turn ON and turn OFF IFN-{gamma} production in direct response to Ag contact, presumably to minimize the potential immunopathology that could result from inappropriate secretion of this inflammatory mediator. In this study, we show, using in vitro propagated and directly ex vivo-analyzed Ag-specific CD8+ T cells, that in contrast to Ag-dependent ON/OFF cycling of IFN-{gamma} production, the cessation of TNF production by the same IFN-{gamma} producing cells is rapid and Ag independent.




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