| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
*
Department of Microbiology and
Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242
Although they are known for their capacity to kill infected
cells, Ag-specific CD8+ T cells elaborate other effector
mechanisms, including TNF and IFN-
, that contribute to defense
against infection. Ag-specific CD8+ T cells rapidly turn ON
and turn OFF IFN- production in direct response to Ag contact,
presumably to minimize the potential immunopathology that could result
from inappropriate secretion of this inflammatory mediator. In this
study, we show, using in vitro propagated and directly ex vivo-analyzed
Ag-specific CD8+ T cells, that in contrast to Ag-dependent
ON/OFF cycling of IFN- production, the cessation of TNF production
by the same IFN- producing cells is rapid and Ag
independent.
This article has been cited by other articles:
|
|
 |
|
  C. P. Marques, M. C-J. Cheeran, J. M. Palmquist, S. Hu, S. L. Urban, and J. R. Lokensgard Prolonged Microglial Cell Activation and Lymphocyte Infiltration following Experimental Herpes Encephalitis J. Immunol., November 1, 2008; 181(9): 6417 - 6426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Bitsaktsis and G. Winslow Fatal Recall Responses Mediated by CD8 T cells during Intracellular Bacterial Challenge Infection J. Immunol., October 1, 2006; 177(7): 4644 - 4651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Lindell, M. N. Ballinger, R. A. McDonald, G. B. Toews, and G. B. Huffnagle Immunologic Homeostasis during Infection: Coexistence of Strong Pulmonary Cell-Mediated Immunity to Secondary Cryptococcus neoformans Infection While the Primary Infection Still Persists at Low Levels in the Lungs J. Immunol., October 1, 2006; 177(7): 4652 - 4661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Virna, M. Deckert, S. Lutjen, S. Soltek, K. E. Foulds, H. Shen, H. Korner, J. D. Sedgwick, and D. Schluter TNF Is Important for Pathogen Control and Limits Brain Damage in Murine Cerebral Listeriosis J. Immunol., September 15, 2006; 177(6): 3972 - 3982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Brehm, K. A. Daniels, and R. M. Welsh Rapid Production of TNF-{alpha} following TCR Engagement of Naive CD8 T Cells J. Immunol., October 15, 2005; 175(8): 5043 - 5049. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Beadling and M. K. Slifka Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines Blood, February 1, 2005; 105(3): 1179 - 1186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Corbin and J. T. Harty T Cells Undergo Rapid ON/OFF but Not ON/OFF/ON Cycling of Cytokine Production in Response to Antigen J. Immunol., January 15, 2005; 174(2): 718 - 726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ramakrishna, S. A. Stohlman, R. A. Atkinson, D. R. Hinton, and C. C. Bergmann Differential Regulation of Primary and Secondary CD8+ T Cells in the Central Nervous System J. Immunol., November 15, 2004; 173(10): 6265 - 6273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Kirby, M. Sundquist, and M. J. Wick In Vivo Compartmentalization of Functionally Distinct, Rapidly Responsive Antigen-Specific T-Cell Populations in DNA-Immunized or Salmonella enterica Serovar Typhimurium-Infected Mice Infect. Immun., November 1, 2004; 72(11): 6390 - 6400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Murray and I. N. Crispe TNF-{alpha} Controls Intrahepatic T Cell Apoptosis and Peripheral T Cell Numbers J. Immunol., August 15, 2004; 173(4): 2402 - 2409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Boissonnas, C. Combadiere, E. Lavergne, M. Maho, C. Blanc, P. Debre, and B. Combadiere Antigen Distribution Drives Programmed Antitumor CD8 Cell Migration and Determines Its Efficiency J. Immunol., July 1, 2004; 173(1): 222 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Liu, J. L. Whitton, and M. K. Slifka The Rapidity with Which Virus-Specific CD8+ T Cells Initiate IFN-{gamma} Synthesis Increases Markedly over the Course of Infection and Correlates with Immunodominance J. Immunol., July 1, 2004; 173(1): 456 - 462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Zhou, R. Ou, L. Huang, G. E. Price, and D. Moskophidis Differential Tissue-Specific Regulation of Antiviral CD8+ T-Cell Immune Responses during Chronic Viral Infection J. Virol., April 1, 2004; 78(7): 3578 - 3600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Khanolkar, M. J. Fuller, and A. J. Zajac CD4 T Cell-Dependent CD8 T Cell Maturation J. Immunol., March 1, 2004; 172(5): 2834 - 2844. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Wherry, J. N. Blattman, K. Murali-Krishna, R. van der Most, and R. Ahmed Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment J. Virol., April 15, 2003; 77(8): 4911 - 4927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Bergmann, B. Parra, D. R. Hinton, R. Chandran, M. Morrison, and S. A. Stohlman Perforin-Mediated Effector Function Within the Central Nervous System Requires IFN-{gamma}-Mediated MHC Up-Regulation J. Immunol., March 15, 2003; 170(6): 3204 - 3213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Fuller and A. J. Zajac Ablation of CD8 and CD4 T Cell Responses by High Viral Loads J. Immunol., January 1, 2003; 170(1): 477 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Sun, R. L. Burton, and K. G. Lucas Cytokine production and cytolytic mechanism of CD4+ cytotoxic T lymphocytes in ex vivo expanded therapeutic Epstein-Barr virus-specific T-cell cultures Blood, May 1, 2002; 99(9): 3302 - 3309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zhou, R. Ou, L. Huang, and D. Moskophidis Critical Role for Perforin-, Fas/FasL-, and TNFR1-Mediated Cytotoxic Pathways in Down-Regulation of Antigen-Specific T Cells during Persistent Viral Infection J. Virol., January 15, 2002; 76(2): 829 - 840. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
