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ß TCR Complex1
*
Department of Hematopoietic Factors, Institute of Medical Science, University of Tokyo, Tokyo, Japan;
Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; and
Biotechnology Research Laboratories, Takara Shuzo, Shiga, Japan
Transfer of the 
ß TCR genes into T lymphocytes will provide a
means to enhance Ag-specific immunity by increasing the frequency of
tumor- or pathogen-specific T lymphocytes. We generated an efficient
ß TCR gene transfer system using two independent monocistronic
retrovirus vectors harboring either of the class II MHC-restricted
or ß TCR genes specific for chicken OVA. The system enabled us to
express the clonotypic TCR in 44% of the CD4+ T cells. The
transduced cells showed a remarkable response to
OVA323–339 peptide in the in vitro culture system, and the
response to the Ag was comparable with those of the T lymphocytes
derived from transgenic mice harboring OVA-specific TCR. Adoptive
transfer of the TCR-transduced cells in mice induced the Ag-specific
delayed-type hypersensitivity in response to OVA323–339
challenge. These results indicate that ß TCR gene transfer into
peripheral T lymphocytes can reconstitute Ag-specific immunity. We here
propose that this method provides a basis for a new approach to
manipulation of immune reactions and
immunotherapy.
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