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*
Immunology Section, Department of Cell and Molecular Biology, Lund University, Lund, Sweden; and
Gwen Knapp Center for Lupus and Immunology Research, Committee on Immunology and Department of Pathology, University of Chicago, Chicago, IL 60637
The majority of T lymphocytes carrying the NK cell marker NK1.1
(NKT cells) depend on the CD1d molecule for their development and are
distinguished by their potent capacity to rapidly secrete cytokines
upon activation. A substantial fraction of NKT cells express a
restricted TCR repertiore using an invariant TCR V
14-J281
rearrangement and a limited set of TCR Vß segments, implying
recognition of a limited set of CD1d-associated ligands. A second group
of CD1d-reactive T cells use diverse TCR potentially recognizing a
larger diversity of ligands presented on CD1d. In TCR-transgenic mice
carrying rearranged TCR genes from a CD1d-reactive T cell with the
diverse type receptor (using V3.2/Vß9 rearrangements), the
majority of T cells expressing the transgenic TCR had the typical
phenotype of NKT cells. They expressed NK1.1, CD122, intermediate TCR
levels, and markers indicating previous activation and were CD4/CD8
double negative or CD4+. Upon activation in vitro, the
cells secreted large amounts of IL-4 and IFN-
, a characteristic of
NKT cells. In mice lacking CD1d, TCR-transgenic cells with the NKT
phenotype were absent. This demonstrates that a CD1d-reactive TCR of
the "non-V 14" diverse type can, in a ligand-dependent way,
direct development of NK1.1+ T cells expressing expected
functional and cell-surface phenotype
characteristics.
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