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CUTTING EDGE |
*
Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, and Walther Cancer Institute, Indianapolis, IN 46208; and
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109
The in vivo function of Th cell subsets is largely dependent on
the ability of differentiated CD4+ T cells to be recruited
to specific sites and secrete restricted sets of cytokines. In this
paper we demonstrate that Th1 and Th2 cells secrete discrete patterns
of chemokines, small m.w. cytokines that function as chemoattractants
in inflammatory reactions. Th2 cells secrete macrophage-derived
chemokine and T cell activation gene 3, and acquisition of this pattern
of expression is dependent on Stat6. In contrast, Th1 cells secrete
lymphotactin and RANTES, though unlike IFN-
, expression of these
chemokines is independent of Stat4. We further show that supernatants
from activated Th2 cells preferentially induce the chemotaxis of Th2
over Th1 cells, corresponding with Stat6-dependent expression of CCR4
and CCR8 in Th2 cells. These data provide the basis for restricted and
direct T cell-mediated cellular recruitment to sites of
inflammation.
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