The JI Acurri Cytometers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     
 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Halloran, M. M.
Right arrow Articles by Koch, A. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Halloran, M. M.
Right arrow Articles by Koch, A. E.
The Journal of Immunology, 2000, 164: 4868-4877.
Copyright © 2000 by The American Association of Immunologists

Ley/H: An Endothelial-Selective, Cytokine-Inducible, Angiogenic Mediator1

Margaret M. Halloran*, William W. Carley§, Peter J. Polverini||, Catherine J. Haskell*, Stacie Phan§, Byron J. Anderson{dagger}, James M. Woods*, Phillip L. Campbell*, Michael V. Volin*, Annika E. Bäcker and Alisa E. Koch2,*,{ddagger}

* Department of Medicine, Section of Arthritis and Connective Tissue Diseases, and {dagger} Department of Cellular and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611; {ddagger} Veterans Administration Chicago Health Care System, Lakeside Division, Chicago, IL 60611; § Bayer Corp., West Haven, CT 06516; Department of Laboratory Medicine, Sahlgrenska Hospital, Goteborg, Sweden; and || Laboratory of Molecular Pathogenesis, University of Michigan Dental School, Ann Arbor, MI 48108

Endothelial cells (ECs) are key participants in angiogenic processes that characterize tumor growth, wound repair, and inflammatory diseases, such as human rheumatoid arthritis (RA). We and others have shown that EC molecules, such as soluble E-selectin, mediate angiogenesis. Here we describe an EC molecule, Lewisy-6/H-5-2 glycoconjugate (Ley/H), that shares some structural features with the soluble E-selectin ligand, sialyl Lewisx (sialyl Lex). One of the main previously recognized functions of Lewisy is as a blood group glycoconjugate. Here we show that Ley/H is rapidly cytokine inducible, up-regulated in RA synovial tissue, where it is cell-bound, and up-regulated in the soluble form in angiogenic RA compared with nonangiogenic osteoarthritic joint fluid. Soluble Ley/H also has a novel function, for it is a potent angiogenic mediator in both in vitro and in vivo bioassays. These results suggest a novel paradigm of soluble blood group Ags as mediators of angiogenic responses and suggest new targets for therapy of diseases, such as RA, that are characterized by persistent neovascularization.







HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.