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9 B Cell Antigen Receptor Drives Generation of CD5+ B Cells Both In Vivo and In Vitro1
*
Division of Basic Sciences, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206;
Department of Immunology, University of Colorado Health Sciences Center, Denver, CO 80206;
Department of Microbiology and Immunology, Shimane Medical University, Izumo, Shimane, Japan,
§
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037; and
¶
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111
B lymphocytes can be divided into different subpopulations, some
with distinctive activation requirements and probably mediating
specialized functions, based on surface phenotype and/or anatomical
location, but the origins of most of these populations remain poorly
understood. B cells constrained by transgenesis to produce an Ag
receptor derived from a conventional (B-2) type cell develop a B-2
phenotype, whereas cells from mice carrying a B-1-derived receptor
acquire the B-1 phenotype. In this study transgenic enforced expression
of a B cell receptor (µ/
) originally isolated from a
CD5+ (B-1a) B cell generates B-1 phenotype cells in bone
marrow cultures that show a distinctive B-1 function, survival in
culture. Despite their autoreactivity, we find no evidence for receptor
editing or that the paucity of B-2 cells is the result of
tolerance-induced selection. Finally, Ca2+ mobilization
studies reveal a difference between transgenic B-1 cells in spleen and
peritoneal cavity, with cells in spleen much more responsive to
anti-B cell receptor cross-linking. We discuss these results in
terms of specificity vs lineage models for generation of distinctive B
cell subpopulations.
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