| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Microbiology and Center for Immunology, University of Minnesota, Minneapolis, MN 55455
It is thought that protective immunity is mediated in part by Ag-experienced T cells that respond more quickly and vigorously than naive T cells. Using adoptive transfer of OVA-specific CD4 T cells from TCR transgenic mice as a model system, we show that Ag-experienced CD4 T cells accumulate in lymph nodes more rapidly than naive T cells after in vivo challenge with Ag. However, the magnitude of clonal expansion by Ag-experienced T cells was much less than that of naive T cells, particularly at early times after primary immunization. Ag-experienced CD4 T cells quickly reverted to the slower but more robust clonal expansion behavior of naive T cells after transfer into a naive environment. Conversely, the capacity for rapid clonal expansion was acquired by naive CD4 T cells after transfer into passively immunized recipients. These results indicate that rapid in vivo response by Ag-experienced T cells is facilitated by Ag-specific Abs, whereas the limited capacity for clonal expansion is imposed by some other factor in the immune environment, perhaps residual Ag.
This article has been cited by other articles:
|
|
 |
|
  M. K. L. MacLeod, A. McKee, F. Crawford, J. White, J. Kappler, and P. Marrack CD4 memory T cells divide poorly in response to antigen because of their cytokine profile PNAS, September 23, 2008; 105(38): 14521 - 14526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Xiao, A. Kroemer, W. Gao, N. Ishii, G. Demirci, and X. C. Li OX40/OX40L Costimulation Affects Induction of Foxp3+ Regulatory T Cells in Part by Expanding Memory T Cells In Vivo J. Immunol., September 1, 2008; 181(5): 3193 - 3201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Helft, A. Jacquet, N. T. Joncker, I. Grandjean, G. Dorothee, A. Kissenpfennig, B. Malissen, P. Matzinger, and O. Lantz Antigen-specific T-T interactions regulate CD4 T-cell expansion Blood, August 15, 2008; 112(4): 1249 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Duffy, S. M. Sparshott, C.-p. Yang, and E. B. Bell Transgenic CD4 T Cells (DO11.10) Are Destroyed in MHC-Compatible Hosts by NK Cells and CD8 T Cells J. Immunol., January 15, 2008; 180(2): 747 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Mueller, M. S. Thomas, B. J. Burbach, E. J. Peterson, and Y. Shimizu Adhesion and Degranulation-Promoting Adapter Protein (ADAP) Positively Regulates T Cell Sensitivity to Antigen and T Cell Survival J. Immunol., September 15, 2007; 179(6): 3559 - 3569. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. MacLeod, M. J. Kwakkenbos, A. Crawford, S. Brown, B. Stockinger, K. Schepers, T. Schumacher, and D. Gray CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40 J. Exp. Med., April 17, 2006; 203(4): 897 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Catron, L. K. Rusch, J. Hataye, A. A. Itano, and M. K. Jenkins CD4+ T cells that enter the draining lymph nodes after antigen injection participate in the primary response and become central-memory cells J. Exp. Med., April 17, 2006; 203(4): 1045 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-P. Yang, S. M. Sparshott, D. Duffy, P. Garside, and E. B. Bell The phenotype and survival of antigen-stimulated transgenic CD4 T cells in vivo: the influence of persisting antigen Int. Immunol., April 1, 2006; 18(4): 515 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Liu, Q. Liu, H. Hamed, R. M. Anthony, A. Foster, F. D. Finkelman, J. F. Urban Jr, and W. C. Gause IL-2 and Autocrine IL-4 Drive the In Vivo Development of Antigen-Specific Th2 T Cells Elicited by Nematode Parasites J. Immunol., February 15, 2005; 174(4): 2242 - 2249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. R. Millington, A. McI. Mowat, and P. Garside Induction of Bystander Suppression by Feeding Antigen Occurs despite Normal Clonal Expansion of the Bystander T Cell Population J. Immunol., November 15, 2004; 173(10): 6059 - 6064. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. Zand, B. J. Briggs, A. Bose, and T. Vo Discrete Event Modeling of CD4+ Memory T Cell Generation J. Immunol., September 15, 2004; 173(6): 3763 - 3772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Anderson and K. L. Fritsche Dietary Polyunsaturated Fatty Acids Modulate In Vivo, Antigen-Driven CD4+ T-Cell Proliferation in Mice J. Nutr., August 1, 2004; 134(8): 1978 - 1983. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Parameswaran, D. J. Samuvel, R. Kumar, S. Thatai, V. Bal, S. Rath, and A. George Oral Tolerance in T Cells Is Accompanied by Induction of Effector Function in Lymphoid Organs after Systemic Immunization Infect. Immun., July 1, 2004; 72(7): 3803 - 3811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Getahun, J. Dahlstrom, S. Wernersson, and B. Heyman IgG2a-Mediated Enhancement of Antibody and T Cell Responses and Its Relation to Inhibitory and Activating Fc{gamma} Receptors J. Immunol., May 1, 2004; 172(9): 5269 - 5276. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Attanavanich and J. F. Kearney Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T Cells J. Immunol., January 15, 2004; 172(2): 803 - 811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A. Pape, V. Kouskoff, D. Nemazee, H. L. Tang, J. G. Cyster, L. E. Tze, K. L. Hippen, T. W. Behrens, and M. K. Jenkins Visualization of the Genesis and Fate of Isotype-switched B Cells during a Primary Immune Response J. Exp. Med., June 16, 2003; 197(12): 1677 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Beacock-Sharp, A. M. Donachie, N. C. Robson, and A. M. Mowat A role for dendritic cells in the priming of antigen-specific CD4+ and CD8+ T lymphocytes by immune-stimulating complexes in vivo Int. Immunol., June 1, 2003; 15(6): 711 - 720. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. T. Moses, K. M. Thorstenson, S. C. Jameson, and A. Khoruts Competition for self ligands restrains homeostatic proliferation of naive CD4 T cells PNAS, February 4, 2003; 100(3): 1185 - 1190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Ingulli, D. R. Ulman, M. M. Lucido, and M. K. Jenkins In Situ Analysis Reveals Physical Interactions Between CD11b+ Dendritic Cells and Antigen-Specific CD4 T Cells After Subcutaneous Injection of Antigen J. Immunol., September 1, 2002; 169(5): 2247 - 2252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Smith, F. McAskill, and P. Garside Orally Tolerized T Cells Are Only Able to Enter B Cell Follicles Following Challenge with Antigen in Adjuvant, but They Remain Unable to Provide B Cell Help J. Immunol., May 1, 2002; 168(9): 4318 - 4325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sester, U. Sester, B. Gartner, B. Kubuschok, M. Girndt, A. Meyerhans, and H. Kohler Sustained High Frequencies of Specific CD4 T Cells Restricted to a Single Persistent Virus J. Virol., March 19, 2002; 76(8): 3748 - 3755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. E. Foulds, L. A. Zenewicz, D. J. Shedlock, J. Jiang, A. E. Troy, and H. Shen Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses J. Immunol., February 15, 2002; 168(4): 1528 - 1532. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Iwakoshi, T. G. Markees, N. Turgeon, T. Thornley, A. Cuthbert, J. Leif, N. E. Phillips, J. P. Mordes, D. L. Greiner, and A. A. Rossini4 Skin Allograft Maintenance in a New Synchimeric Model System of Tolerance J. Immunol., December 1, 2001; 167(11): 6623 - 6630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Thorstenson and A. Khoruts Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen J. Immunol., July 1, 2001; 167(1): 188 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. N. Shi, H. Y. Liu, and C. Nagler-Anderson Enteric Infection Acts as an Adjuvant for the Response to a Model Food Antigen J. Immunol., December 1, 2000; 165(11): 6174 - 6182. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Zell, A. Khoruts, E. Ingulli, J. L. Bonnevier, D. L. Mueller, and M. K. Jenkins Single-cell analysis of signal transduction in CD4 T cells stimulated by antigen in vivo PNAS, September 11, 2001; 98(19): 10805 - 10810. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
