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Kali
ski2,*
Departments of
*
Cell Biology and Histology and
Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
Dendritic cells (DC) are key initiators of primary immune
responses. Myeloid DC can secrete IL-12, a potent Th1-driving factor,
and are often viewed as Th1-promoting APC. Here we show that neither a
Th1- nor a Th2-inducing function is an intrinsic attribute of human
myeloid DC, but both depend on environmental instruction. Uncommitted
immature DC require exposure to IFN-
, at the moment of induction of
their maturation or shortly thereafter, to develop the capacity to
produce high levels of IL-12p70 upon subsequent contact with naive Th
cells. This effect is specific for IFN- and is not shared by other
IL-12-inducing factors. Type 1-polarized effector DC, matured in the
presence of IFN-, induce Th1 responses, in contrast to type
2-polarized DC matured in the presence of PGE2 that induce
Th2 responses. Type 1-polarized effector DC are resistant to further
modulation, which may facilitate their potential use in
immunotherapy.
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A Fukushima, K Fukata, A Ozaki, M Takata, N Kuroda, H Enzan, and H Ueno Exertion of the suppressive effects of IFN-{gamma} on experimental immune mediated blepharoconjunctivitis in Brown Norway rats during the induction phase but not the effector phase Br J Ophthalmol, October 1, 2002; 86(10): 1166 - 1171. [Abstract] [Full Text] [PDF]
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J. H. Ahn, Y. Lee, C. Jeon, S.-J. Lee, B.-H. Lee, K. D. Choi, and Y.-S. Bae Identification of the genes differentially expressed in human dendritic cell subsets by cDNA subtraction and microarray analysis Blood, August 13, 2002; 100(5): 1742 - 1754. [Abstract] [Full Text] [PDF]
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H. J. Bontkes, T. D. de Gruijl, G. J. Schuurhuis, R. J. Scheper, C. J. L. M. Meijer, and E. Hooijberg Expansion of dendritic cell precursors from human CD34+ progenitor cells isolated from healthy donor blood; growth factor combination determines proliferation rate and functional outcome J. Leukoc. Biol., August 1, 2002; 72(2): 321 - 329. [Abstract] [Full Text] [PDF]
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 A. G.S. van Halteren, E. van Etten, E. C. de Jong, R. Bouillon, B. O. Roep, and C. Mathieu Redirection of Human Autoreactive T-Cells Upon Interaction With Dendritic Cells Modulated by TX527, an Analog of 1,25 Dihydroxyvitamin D3 Diabetes, July 1, 2002; 51(7): 2119 - 2125. [Abstract] [Full Text] [PDF]
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 R. W. Sanders, E. C. de Jong, C. E. Baldwin, J. H. N. Schuitemaker, M. L. Kapsenberg, and B. Berkhout Differential Transmission of Human Immunodeficiency Virus Type 1 by Distinct Subsets of Effector Dendritic Cells J. Virol., June 27, 2002; 76(15): 7812 - 7821. [Abstract] [Full Text] [PDF]
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T. Ito, R. Amakawa, T. Kaisho, H. Hemmi, K. Tajima, K. Uehira, Y. Ozaki, H. Tomizawa, S. Akira, and S. Fukuhara Interferon-{alpha} and Interleukin-12 Are Induced Differentially by Toll-like Receptor 7 Ligands in Human Blood Dendritic Cell Subsets J. Exp. Med., June 3, 2002; 195(11): 1507 - 1512. [Abstract] [Full Text] [PDF]
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 T. K. Hoffmann, J. Muller-Berghaus, R. L. Ferris, J. T. Johnson, W. J. Storkus, and T. L. Whiteside Alterations in the Frequency of Dendritic Cell Subsets in the Peripheral Circulation of Patients with Squamous Cell Carcinomas of the Head and Neck Clin. Cancer Res., June 1, 2002; 8(6): 1787 - 1793. [Abstract] [Full Text] [PDF]
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C. C. Sombroek, A. G. M. Stam, A. J. Masterson, S. M. Lougheed, M. J. A. G. Schakel, C. J. L. M. Meijer, H. M. Pinedo, A. J. M. van den Eertwegh, R. J. Scheper, and T. D. de Gruijl Prostanoids Play a Major Role in the Primary Tumor-Induced Inhibition of Dendritic Cell Differentiation J. Immunol., May 1, 2002; 168(9): 4333 - 4343. [Abstract] [Full Text] [PDF]
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S. P. Hickman, J. Chan, and P. Salgame Mycobacterium tuberculosis Induces Differential Cytokine Production from Dendritic Cells and Macrophages with Divergent Effects on Naive T Cell Polarization J. Immunol., May 1, 2002; 168(9): 4636 - 4642. [Abstract] [Full Text] [PDF]
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R. B. Mailliard, S. Egawa, Q. Cai, A. Kalinska, S. N. Bykovskaya, M. T. Lotze, M. L. Kapsenberg, W. J. Storkus, and P. Kalinski Complementary Dendritic Cell-activating Function of CD8+ and CD4+ T Cells: Helper Role of CD8+ T Cells in the Development of T Helper Type 1 Responses J. Exp. Med., February 19, 2002; 195(4): 473 - 483. [Abstract] [Full Text] [PDF]
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E. C. de Jong, P. L. Vieira, P. Kalinski, J. H. N. Schuitemaker, Y. Tanaka, E. A. Wierenga, M. Yazdanbakhsh, and M. L. Kapsenberg Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals J. Immunol., February 15, 2002; 168(4): 1704 - 1709. [Abstract] [Full Text] [PDF]
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H. H. Smits, E. C. de Jong, J. H. N. Schuitemaker, T. B. H. Geijtenbeek, Y. van Kooyk, M. L. Kapsenberg, and E. A. Wierenga Intercellular Adhesion Molecule-1/LFA-1 Ligation Favors Human Th1 Development J. Immunol., February 15, 2002; 168(4): 1710 - 1716. [Abstract] [Full Text] [PDF]
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 M. F. Lipscomb and B. J. Masten Dendritic Cells: Immune Regulators in Health and Disease Physiol Rev, January 1, 2002; 82(1): 97 - 130. [Abstract] [Full Text] [PDF]
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H. R. Christensen, H. Frokiar, and J. J. Pestka Lactobacilli Differentially Modulate Expression of Cytokines and Maturation Surface Markers in Murine Dendritic Cells J. Immunol., January 1, 2002; 168(1): 171 - 178. [Abstract] [Full Text] [PDF]
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B. Pulendran, P. Kumar, C. W. Cutler, M. Mohamadzadeh, T. Van Dyke, and J. Banchereau Lipopolysaccharides from Distinct Pathogens Induce Different Classes of Immune Responses In Vivo J. Immunol., November 1, 2001; 167(9): 5067 - 5076. [Abstract] [Full Text] [PDF]
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R. Maldonado-Lopez, C. Maliszewski, J. Urbain, and M. Moser Cytokines Regulate the Capacity of CD8{alpha}+ and CD8{alpha}- Dendritic Cells to Prime Th1/Th2 Cells In Vivo J. Immunol., October 15, 2001; 167(8): 4345 - 4350. [Abstract] [Full Text] [PDF]
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M. B. Faries, I. Bedrosian, S. Xu, G. Koski, J. G. Roros, M. A. Moise, H. Q. Nguyen, F. H. C. Engels, P. A. Cohen, and B. J. Czerniecki Calcium signaling inhibits interleukin-12 production and activates CD83+ dendritic cells that induce Th2 cell development Blood, October 15, 2001; 98(8): 2489 - 2497. [Abstract] [Full Text] [PDF]
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G. Caron, Y. Delneste, E. Roelandts, C. Duez, J.-Y. Bonnefoy, J. Pestel, and P. Jeannin Histamine Polarizes Human Dendritic Cells into Th2 Cell-Promoting Effector Dendritic Cells J. Immunol., October 1, 2001; 167(7): 3682 - 3686. [Abstract] [Full Text] [PDF]
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M. Sato, K. Chamoto, T. Tsuji, Y. Iwakura, Y. Togashi, T. Koda, and T. Nishimura Th1 Cytokine-Conditioned Bone Marrow-Derived Dendritic Cells Can Bypass the Requirement for Th Functions During the Generation of CD8+ CTL J. Immunol., October 1, 2001; 167(7): 3687 - 3691. [Abstract] [Full Text] [PDF]
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A. Puig-Kroger, M. Relloso, O. Fernandez-Capetillo, A. Zubiaga, A. Silva, C. Bernabeu, and A. L. Corbi Extracellular signal-regulated protein kinase signaling pathway negatively regulates the phenotypic and functional maturation of monocyte-derived human dendritic cells Blood, October 1, 2001; 98(7): 2175 - 2182. [Abstract] [Full Text] [PDF]
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A. E. Morelli, A. F. Zahorchak, A. T. Larregina, B. L. Colvin, A. J. Logar, T. Takayama, L. D. Falo, and A. W. Thomson Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation Blood, September 1, 2001; 98(5): 1512 - 1523. [Abstract] [Full Text] [PDF]
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 S. K. Bliss, L. C. Gavrilescu, A. Alcaraz, and E. Y. Denkers Neutrophil Depletion during Toxoplasma gondii Infection Leads to Impaired Immunity and Lethal Systemic Pathology Infect. Immun., August 1, 2001; 69(8): 4898 - 4905. [Abstract] [Full Text] [PDF]
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A. K. Wesa and A. Galy IL-1{beta} induces dendritic cells to produce IL-12 Int. Immunol., August 1, 2001; 13(8): 1053 - 1061. [Abstract] [Full Text] [PDF]
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L.-Y. Huang, C. Reis e Sousa, Y. Itoh, J. Inman, and D. E. Scott IL-12 Induction by a Th1-Inducing Adjuvant In Vivo: Dendritic Cell Subsets and Regulation by IL-10 J. Immunol., August 1, 2001; 167(3): 1423 - 1430. [Abstract] [Full Text] [PDF]
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 K. L. Summers, B. D. Hock, J. L. McKenzie, and D. N. J. Hart Phenotypic Characterization of Five Dendritic Cell Subsets in Human Tonsils Am. J. Pathol., July 1, 2001; 159(1): 285 - 295. [Abstract] [Full Text] [PDF]
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R. Kammerer, D. Stober, B. B. Singer, B. Obrink, and J. Reimann Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 on Murine Dendritic Cells Is a Potent Regulator of T Cell Stimulation J. Immunol., June 1, 2001; 166(11): 6537 - 6544. [Abstract] [Full Text] [PDF]
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P. Lenz, P. M. Day, Y.-Y. S. Pang, S. A. Frye, P. N. Jensen, D. R. Lowy, and J. T. Schiller Papillomavirus-Like Particles Induce Acute Activation of Dendritic Cells J. Immunol., May 1, 2001; 166(9): 5346 - 5355. [Abstract] [Full Text] [PDF]
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Y.-M. Huang, M. Kouwenhoven, Y.-P. Jin, R. Press, W.-X. Huang, and H. Link Dendritic cells derived from patients with multiple sclerosis show high CD1a and low CD86 expression Multiple Sclerosis, April 1, 2001; 7(2): 95 - 99. [Abstract] [PDF]
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 M. Pashenkov, Y.-M. Huang, V. Kostulas, M. Haglund, M. Soderstrom, and H. Link Two subsets of dendritic cells are present in human cerebrospinal fluid Brain, March 1, 2001; 124(3): 480 - 492. [Abstract] [Full Text] [PDF]
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H.-G. Fischer and G. Reichmann Brain Dendritic Cells and Macrophages/Microglia in Central Nervous System Inflammation J. Immunol., February 15, 2001; 166(4): 2717 - 2726. [Abstract] [Full Text] [PDF]
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J. Banchereau, B. Pulendran, R. Steinman, and K. Palucka Will the Making of Plasmacytoid Dendritic Cells in Vitro Help Unravel Their Mysteries? J. Exp. Med., December 18, 2000; 192(12): f39 - f44. [Full Text] [PDF]
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