| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
24JQ Invariant TCR Chain in the Lesions of Multiple Sclerosis and Chronic Inflammatory Demyelinating Polyneuropathy1
*
Department of Demyelinating Disease and Aging, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan;
NeuroResource, Institute of Neurology, London, United Kingdom;
Department of Neurology, Faculty of Medicine, Kyoto University, Kyoto, Japan; and
§
Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Human V
24+ NK T cells are a unique subset of
lymphocytes expressing the V24JQ invariant TCR chain. Because
they can rapidly produce large amounts of regulatory cytokines, a
reduction of NK T cells may lead to the development of certain
autoimmune diseases. Using a single-strand conformation polymorphism
method, we demonstrate that a great reduction of V24JQ NK T cells
in the peripheral blood is an immunological hallmark of multiple
sclerosis, whereas it is not appreciable in other
autoimmune/inflammatory diseases such as chronic inflammatory
demyelinating polyneuropathy. The chronic inflammatory demyelinating
polyneuropathy lesions were often found to be infiltrated with
V24JQ NK T cells, but multiple sclerosis lesions only rarely
expressed the V24JQ TCR. It is therefore possible that the extent
of NK T cell alteration may be a critical factor which would define the
clinical and pathological features of autoimmune disease. Although the
mechanism underlying the NK T cell deletion remains largely unclear, a
remarkable contrast between the CNS and peripheral nervous system
diseases allows us to speculate a role of tissue-specific elements such
as the level of CD1d expression or differences in the CD1d-bound
glycolipid.
This article has been cited by other articles:
|
|
 |
|
  M Podbielska and E. Hogan Molecular and immunogenic features of myelin lipids: incitants or modulators of multiple sclerosis? Multiple Sclerosis, September 1, 2009; 15(9): 1011 - 1029. [Abstract] [PDF]
|
|
|
|
 |
|
 H. C. Lehmann, G. Meyer zu Horste, B. C. Kieseier, and H.-P. Hartung Review: Pathogenesis and treatment of immune-mediated neuropathies Therapeutic Advances in Neurological Disorders, July 1, 2009; 2(4): 261 - 281. [Abstract] [PDF]
|
|
|
|
 |
|
 A. Peterfalvi, E. Gomori, T. Magyarlaki, J. Pal, M. Banati, A. Javorhazy, J. Szekeres-Bartho, L. Szereday, and Z. Illes Invariant V{alpha}7.2-J{alpha}33 TCR is expressed in human kidney and brain tumors indicating infiltration by mucosal-associated invariant T (MAIT) cells Int. Immunol., December 1, 2008; 20(12): 1517 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Tsunoda, T. Tanaka, and R. S. Fujinami Regulatory Role of CD1d in Neurotropic Virus Infection J. Virol., October 15, 2008; 82(20): 10279 - 10289. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Diao, K. Iwabuchi, L. Li, K. Onoe, L. Van Kaer, S. Kon, Y. Saito, J. Morimoto, D. T. Denhardt, S. Rittling, et al. Osteopontin regulates development and function of invariant natural killer T cells PNAS, October 14, 2008; 105(41): 15884 - 15889. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. T. Mars, A.-S. Gautron, J. Novak, L. Beaudoin, J. Diana, R. S. Liblau, and A. Lehuen Invariant NKT Cells Regulate Experimental Autoimmune Encephalomyelitis and Infiltrate the Central Nervous System in a CD1d-Independent Manner J. Immunol., August 15, 2008; 181(4): 2321 - 2329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Baev, S. Caielli, F. Ronchi, M. Coccia, F. Facciotti, K. E. Nichols, and M. Falcone Impaired SLAM-SLAM Homotypic Interaction between Invariant NKT Cells and Dendritic Cells Affects Differentiation of IL-4/IL-10-Secreting NKT2 Cells in Nonobese Diabetic Mice J. Immunol., July 15, 2008; 181(2): 869 - 877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Yamaura, C. Hotta, M. Nakazawa, L. Van Kaer, and M. Minami Human invariant V{alpha}24+ natural killer T cells acquire regulatory functions by interacting with IL-10-treated dendritic cells Blood, April 15, 2008; 111(8): 4254 - 4263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Tsukamoto, M. Ohtsuji, W. Shiroiwa, Q. Lin, K. Nakamura, H. Tsurui, Y. Jiang, K. Sudo, H. Nishimura, T. Shirai, et al. Aberrant Genetic Control of Invariant TCR-Bearing NKT Cell Function in New Zealand Mouse Strains: Possible Involvement in Systemic Lupus Erythematosus Pathogenesis J. Immunol., April 1, 2008; 180(7): 4530 - 4539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vasan, M. A. Poles, A. Horowitz, E. E. Siladji, M. Markowitz, and M. Tsuji Function of NKT cells, potential anti-HIV effector cells, are improved by beginning HAART during acute HIV-1 infection Int. Immunol., August 16, 2007; (2007) dxm055v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R H Grose, A G Cummins, and F M Thompson Deficiency of invariant natural killer T cells in coeliac disease Gut, June 1, 2007; 56(6): 790 - 795. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wiethe, M. Schiemann, D. Busch, L. Haeberle, M. Kopf, G. Schuler, and M. B. Lutz Interdependency of MHC Class II/Self-Peptide and CD1d/Self-Glycolipid Presentation by TNF-Matured Dendritic Cells for Protection from Autoimmunity J. Immunol., April 15, 2007; 178(8): 4908 - 4916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Im, N. Tapinos, G.-T. Chae, P. A. Illarionov, G. S. Besra, G. H. DeVries, R. L. Modlin, P. A. Sieling, A. Rambukkana, and S. A. Porcelli Expression of CD1d Molecules by Human Schwann Cells and Potential Interactions with Immunoregulatory Invariant NK T Cells J. Immunol., October 15, 2006; 177(8): 5226 - 5235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Kent, Y. Chen, S. M. Clemmings, V. Viglietta, N. S. Kenyon, C. Ricordi, B. Hering, and D. A. Hafler Loss of IL-4 Secretion from Human Type 1a Diabetic Pancreatic Draining Lymph Node NKT Cells J. Immunol., October 1, 2005; 175(7): 4458 - 4464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Minami, Y. Yanagawa, K. Iwabuchi, N. Shinohara, T. Harabayashi, K. Nonomura, and K. Onoe Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions Blood, September 1, 2005; 106(5): 1685 - 1693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Forestier, A. Molano, J. S. Im, Y. Dutronc, B. Diamond, A. Davidson, P. A. Illarionov, G. S. Besra, and S. A. Porcelli Expansion and Hyperactivity of CD1d-Restricted NKT Cells during the Progression of Systemic Lupus Erythematosus in (New Zealand Black x New Zealand White)F1 Mice J. Immunol., July 15, 2005; 175(2): 763 - 770. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Koller, B. C. Kieseier, S. Jander, and H.-P. Hartung Chronic Inflammatory Demyelinating Polyneuropathy N. Engl. J. Med., March 31, 2005; 352(13): 1343 - 1356. [Full Text] [PDF]
|
|
|
|
|
|
J. Feng, T. Misu, K. Fujihara, S. Sakoda, Y. Nakatsuji, H. Fukaura, S. Kikuchi, K. Tashiro, A. Suzumura, N. Ishii, et al. Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis Multiple Sclerosis, October 1, 2004; 10(5): 494 - 498. [Abstract] [PDF]
|
|
|
|
|
|
Y. Nagayama, K. Watanabe, M. Niwa, S. M. McLachlan, and B. Rapoport Schistosoma mansoni and {alpha}-Galactosylceramide: Prophylactic Effect of Th1 Immune Suppression in a Mouse Model of Graves' Hyperthyroidism J. Immunol., August 1, 2004; 173(3): 2167 - 2173. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Roelofs-Haarhuis, X. Wu, and E. Gleichmann Oral Tolerance to Nickel Requires CD4+ Invariant NKT Cells for the Infectious Spread of Tolerance and the Induction of Specific Regulatory T Cells J. Immunol., July 15, 2004; 173(2): 1043 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L.-P. Ho, B. C. Urban, L. Jones, G. S. Ogg, and A. J. McMichael CD4-CD8{alpha}{alpha} Subset of CD1d-Restricted NKT Cells Controls T Cell Expansion J. Immunol., June 15, 2004; 172(12): 7350 - 7358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Falcone, F. Facciotti, N. Ghidoli, P. Monti, S. Olivieri, L. Zaccagnino, E. Bonifacio, G. Casorati, F. Sanvito, and N. Sarvetnick Up-Regulation of CD1d Expression Restores the Immunoregulatory Function of NKT Cells and Prevents Autoimmune Diabetes in Nonobese Diabetic Mice J. Immunol., May 15, 2004; 172(10): 5908 - 5916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Sandberg, C. A. Stoddart, F. Brilot, K. A. Jordan, and D. F. Nixon Development of innate CD4+ {alpha}-chain variable gene segment 24 (V{alpha}24) natural killer T cells in the early human fetal thymus is regulated by IL-7 PNAS, May 4, 2004; 101(18): 7058 - 7063. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Illes, M. Shimamura, J. Newcombe, N. Oka, and T. Yamamura Accumulation of V{alpha}7.2-J{alpha}33 invariant T cells in human autoimmune inflammatory lesions in the nervous system Int. Immunol., February 1, 2004; 16(2): 223 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Im, K. O. A. Yu, P. A. Illarionov, K. P. LeClair, J. R. Storey, M. W. Kennedy, G. S. Besra, and S. A. Porcelli Direct Measurement of Antigen Binding Properties of CD1 Proteins Using Fluorescent Lipid Probes J. Biol. Chem., January 2, 2004; 279(1): 299 - 310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Esteban, T. Tsoutsman, M. A. Jordan, D. Roach, L. D. Poulton, A. Brooks, O. V. Naidenko, S. Sidobre, D. I. Godfrey, and A. G. Baxter Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci J. Immunol., September 15, 2003; 171(6): 2873 - 2878. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Matsuda, L. Gapin, J. L. Baron, S. Sidobre, D. B. Stetson, M. Mohrs, R. M. Locksley, and M. Kronenberg Mouse V{alpha}14i natural killer T cells are resistant to cytokine polarization in vivo PNAS, July 8, 2003; 100(14): 8395 - 8400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Araki, T. Kondo, J. E. Gumperz, M. B. Brenner, S. Miyake, and T. Yamamura Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission Int. Immunol., February 1, 2003; 15(2): 279 - 288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. Kieseier, M. C. Dalakas, and H.-P. Hartung Immune mechanisms in chronic inflammatory demyelinating neuropathy Neurology, December 24, 2002; 59(90126): S7 - 12. [Abstract] [Full Text]
|
|
|
|
|
|
J. K. Sandberg, N. M. Fast, E. H. Palacios, G. Fennelly, J. Dobroszycki, P. Palumbo, A. Wiznia, R. M. Grant, N. Bhardwaj, M. G. Rosenberg, et al. Selective Loss of Innate CD4+ V{alpha}24 Natural Killer T Cells in Human Immunodeficiency Virus Infection J. Virol., June 27, 2002; 76(15): 7528 - 7534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. T. Mars, V. Laloux, K. Goude, S. Desbois, A. Saoudi, L. Van Kaer, H. Lassmann, A. Herbelin, A. Lehuen, and R. S. Liblau Cutting Edge: V{alpha}14-J{alpha}281 NKT Cells Naturally Regulate Experimental Autoimmune Encephalomyelitis in Nonobese Diabetic Mice J. Immunol., June 15, 2002; 168(12): 6007 - 6011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Gumperz, S. Miyake, T. Yamamura, and M. B. Brenner Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining J. Exp. Med., March 4, 2002; 195(5): 625 - 636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. Lee, K. Benlagha, L. Teyton, and A. Bendelac Distinct Functional Lineages of Human V{alpha}24 Natural Killer T Cells J. Exp. Med., March 4, 2002; 195(5): 637 - 641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. Jahng, I. Maricic, B. Pedersen, N. Burdin, O. Naidenko, M. Kronenberg, Y. Koezuka, and V. Kumar Activation of Natural Killer T Cells Potentiates or Prevents Experimental Autoimmune Encephalomyelitis J. Exp. Med., December 17, 2001; 194(12): 1789 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Singh, M. T. Wilson, S. Hong, D. Olivares-Villagomez, C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. Van Kaer Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis J. Exp. Med., December 17, 2001; 194(12): 1801 - 1811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D Baeten, N Van Damme, F Van den Bosch, E Kruithof, M De Vos, H Mielants, E M Veys, and F De Keyser Impaired Th1 cytokine production in spondyloarthropathy is restored by anti-TNF{alpha} Ann Rheum Dis, August 1, 2001; 60(8): 750 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Yamazaki, Y. Ohsawa, and H. Yoshie Elevated Proportion of Natural Killer T Cells in Periodontitis Lesions : A Common Feature of Chronic Inflammatory Diseases Am. J. Pathol., April 1, 2001; 158(4): 1391 - 1398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Pal, T. Tabira, T. Kawano, M. Taniguchi, S. Miyake, and T. Yamamura Costimulation-Dependent Modulation of Experimental Autoimmune Encephalomyelitis by Ligand Stimulation of V{{alpha}}14 NK T Cells J. Immunol., January 1, 2001; 166(1): 662 - 668. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
