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*
Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905;
Department of Genetics, Osaka University Medical School, Osaka, Japan;
Human Genome Sciences, Inc., Rockville, MD 20850; and
§
Department of Microbiology and Immunology, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China
LIGHT is a recently identified member of the TNF superfamily and
its receptors, herpesvirus entry mediator and lymphotoxin ß receptor,
are found in T cells and stromal cells. In this study, we demonstrate
that LIGHT is selectively expressed on immature dendritic cells (DCs)
generated from human PBMCs. In contrast, LIGHT is not detectable in DCs
either freshly isolated from PBMCs or rendered mature in vitro by LPS
treatment. Blockade of LIGHT by its soluble receptors, lymphotoxin ß
receptor-Ig or HVEM-Ig, inhibits the induction of DC-mediated primary
allogeneic T cell response. Furthermore, engagement of LIGHT
costimulates human T cell proliferation, amplifies the NF-
B
signaling pathway, and preferentially induces the production of
IFN-
, but not IL-4, in the presence of an antigenic signal. Our
results suggest that LIGHT is a costimulatory molecule involved in
DC-mediated cellular immune responses.
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 R. M. Gill and J. S. Hunt Soluble Receptor (DcR3) and Cellular Inhibitor of Apoptosis-2 (cIAP-2) Protect Human Cytotrophoblast Cells Against LIGHT-Mediated Apoptosis Am. J. Pathol., July 1, 2004; 165(1): 309 - 317. [Abstract] [Full Text] [PDF]
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S. A. Mikolajczak, B. Y. Ma, T. Yoshida, R. Yoshida, D. J. Kelvin, and A. Ochi The Modulation of CD40 Ligand Signaling by Transmembrane CD28 Splice Variant in Human T Cells J. Exp. Med., April 5, 2004; 199(7): 1025 - 1031. [Abstract] [Full Text] [PDF]
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G. Shi, Y. Wu, J. Zhang, and J. Wu Death Decoy Receptor TR6/DcR3 Inhibits T Cell Chemotaxis In Vitro and In Vivo J. Immunol., October 1, 2003; 171(7): 3407 - 3414. [Abstract] [Full Text] [PDF]
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M. A. Medici, M. T. Sciortino, D. Perri, C. Amici, E. Avitabile, M. Ciotti, E. Balestrieri, E. De Smaele, G. Franzoso, and A. Mastino Protection by Herpes Simplex Virus Glycoprotein D against Fas-mediated Apoptosis: ROLE OF NUCLEAR FACTOR {kappa}B J. Biol. Chem., September 19, 2003; 278(38): 36059 - 36067. [Abstract] [Full Text] [PDF]
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 Y. Wu, B. Han, H. Luo, R. Roduit, T. W. Salcedo, P. A. Moore, J. Zhang, and J. Wu DcR3/TR6 Effectively Prevents Islet Primary Nonfunction After Transplantation Diabetes, September 1, 2003; 52(9): 2279 - 2286. [Abstract] [Full Text] [PDF]
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J. Liu, C. S. Schmidt, F. Zhao, A. J. Okragly, A. Glasebrook, N. Fox, E. Galbreath, Q. Zhang, H. Y. Song, S. Na, et al. LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function Int. Immunol., July 1, 2003; 15(7): 861 - 870. [Abstract] [Full Text] [PDF]
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R. A. Fava, E. Notidis, J. Hunt, V. Szanya, N. Ratcliffe, A. Ngam-ek, A. R. de Fougerolles, A. Sprague, and J. L. Browning A Role for the Lymphotoxin/LIGHT Axis in the Pathogenesis of Murine Collagen-Induced Arthritis J. Immunol., July 1, 2003; 171(1): 115 - 126. [Abstract] [Full Text] [PDF]
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A. E. Annenkov, G. M. Daly, T. Brocker, and Y. Chernajovsky Clustering of immunoreceptor tyrosine-based activation motif-containing signalling subunits in CD4+ T cells is an optimal signal for IFN-{gamma} production, but not for the production of IL-4 Int. Immunol., May 1, 2003; 15(5): 665 - 677. [Abstract] [Full Text] [PDF]
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X. Wan, J. Zhang, H. Luo, G. Shi, E. Kapnik, S. Kim, P. Kanakaraj, and J. Wu A TNF Family Member LIGHT Transduces Costimulatory Signals into Human T Cells J. Immunol., December 15, 2002; 169(12): 6813 - 6821. [Abstract] [Full Text] [PDF]
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H. Matsui, Y. Hikichi, I. Tsuji, T. Yamada, and Y. Shintani LIGHT, a Member of the Tumor Necrosis Factor Ligand Superfamily, Prevents Tumor Necrosis Factor-alpha -mediated Human Primary Hepatocyte Apoptosis, but Not Fas-mediated Apoptosis J. Biol. Chem., December 13, 2002; 277(51): 50054 - 50061. [Abstract] [Full Text] [PDF]
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R. M. Gill, J. Ni, and J. S. Hunt Differential Expression of LIGHT and Its Receptors in Human Placental Villi and Amniochorion Membranes Am. J. Pathol., December 1, 2002; 161(6): 2011 - 2017. [Abstract] [Full Text] [PDF]
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R. Castellano, C. Van Lint, V. Peri, E. Veithen, Y. Morel, R. Costello, D. Olive, and Y. Collette Mechanisms Regulating Expression of the Tumor Necrosis Factor-related light Gene. ROLE OF CALCIUM-SIGNALING PATHWAY IN THE TRANSCRIPTIONAL CONTROL J. Biol. Chem., November 1, 2002; 277(45): 42841 - 42851. [Abstract] [Full Text] [PDF]
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G. Shi, H. Luo, X. Wan, T. W. Salcedo, J. Zhang, and J. Wu Mouse T cells receive costimulatory signals from LIGHT, a TNF family member Blood, October 16, 2002; 100(9): 3279 - 3286. [Abstract] [Full Text] [PDF]
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S. Scheu, J. Alferink, T. Potzel, W. Barchet, U. Kalinke, and K. Pfeffer Targeted Disruption of LIGHT Causes Defects in Costimulatory T Cell Activation and Reveals Cooperation with Lymphotoxin {beta} in Mesenteric Lymph Node Genesis J. Exp. Med., June 17, 2002; 195(12): 1613 - 1624. [Abstract] [Full Text] [PDF]
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K. Tamada, J. Ni, G. Zhu, M. Fiscella, B. Teng, J. M. A. van Deursen, and L. Chen Cutting Edge: Selective Impairment of CD8+ T Cell Function in Mice Lacking the TNF Superfamily Member LIGHT J. Immunol., May 15, 2002; 168(10): 4832 - 4835. [Abstract] [Full Text] [PDF]
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T.-L. Hsu, Y.-C. Chang, S.-J. Chen, Y.-J. Liu, A. W. Chiu, C.-C. Chio, L. Chen, and S.-L. Hsieh Modulation of Dendritic Cell Differentiation and Maturation by Decoy Receptor 3 J. Immunol., May 15, 2002; 168(10): 4846 - 4853. [Abstract] [Full Text] [PDF]
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Q. Ye, C. C. Fraser, W. Gao, L. Wang, S. J. Busfield, C. Wang, Y. Qiu, A. J. Coyle, J.-C. Gutierrez-Ramos, and W. W. Hancock Modulation of LIGHT-HVEM Costimulation Prolongs Cardiac Allograft Survival J. Exp. Med., March 18, 2002; 195(6): 795 - 800. [Abstract] [Full Text] [PDF]
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A. S. MacDonald, A. D. Straw, N. M. Dalton, and E. J. Pearce Cutting Edge: Th2 Response Induction by Dendritic Cells: A Role for CD40 J. Immunol., January 15, 2002; 168(2): 537 - 540. [Abstract] [Full Text] [PDF]
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B. Huard, P. Schneider, D. Mauri, J. Tschopp, and L. E. French T Cell Costimulation by the TNF Ligand BAFF J. Immunol., December 1, 2001; 167(11): 6225 - 6231. [Abstract] [Full Text] [PDF]
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Z. Guo, J. Wang, L. Meng, Q. Wu, O. Kim, J. Hart, G. He, P. Zhou, J. R. Thistlethwaite Jr., M.-L. Alegre, et al. Cutting Edge: Membrane Lymphotoxin Regulates CD8+ T Cell-Mediated Intestinal Allograft Rejection J. Immunol., November 1, 2001; 167(9): 4796 - 4800. [Abstract] [Full Text] [PDF]
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J. Wang, T. Chun, J. C. Lo, Q. Wu, Y. Wang, A. Foster, K. Roca, M. Chen, K. Tamada, L. Chen, et al. The Critical Role of LIGHT, a TNF Family Member, in T Cell Development J. Immunol., November 1, 2001; 167(9): 5099 - 5105. [Abstract] [Full Text] [PDF]
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S. W. Granger, K. D. Butrovich, P. Houshmand, W. R. Edwards, and C. F. Ware Genomic Characterization of LIGHT Reveals Linkage to an Immune Response Locus on Chromosome 19p13.3 and Distinct Isoforms Generated by Alternate Splicing or Proteolysis J. Immunol., November 1, 2001; 167(9): 5122 - 5128. [Abstract] [Full Text] [PDF]
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Y. Morel, A. Truneh, R. W. Sweet, D. Olive, and R. T. Costello The TNF Superfamily Members LIGHT and CD154 (CD40 Ligand) Costimulate Induction of Dendritic Cell Maturation and Elicit Specific CTL Activity J. Immunol., September 1, 2001; 167(5): 2479 - 2486. [Abstract] [Full Text] [PDF]
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| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
