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*
Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905;
Department of Genetics, Osaka University Medical School, Osaka, Japan;
Human Genome Sciences, Inc., Rockville, MD 20850; and
§
Department of Microbiology and Immunology, National Yang-Ming University School of Medicine, Taipei, Taiwan, Republic of China
LIGHT is a recently identified member of the TNF superfamily and
its receptors, herpesvirus entry mediator and lymphotoxin ß receptor,
are found in T cells and stromal cells. In this study, we demonstrate
that LIGHT is selectively expressed on immature dendritic cells (DCs)
generated from human PBMCs. In contrast, LIGHT is not detectable in DCs
either freshly isolated from PBMCs or rendered mature in vitro by LPS
treatment. Blockade of LIGHT by its soluble receptors, lymphotoxin ß
receptor-Ig or HVEM-Ig, inhibits the induction of DC-mediated primary
allogeneic T cell response. Furthermore, engagement of LIGHT
costimulates human T cell proliferation, amplifies the NF-
B
signaling pathway, and preferentially induces the production of
IFN-
, but not IL-4, in the presence of an antigenic signal. Our
results suggest that LIGHT is a costimulatory molecule involved in
DC-mediated cellular immune responses.
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