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The Journal of Immunology, 2000, 164: 3950-3954.
Copyright © 2000 by The American Association of Immunologists


CUTTING EDGE

Cutting Edge: Increased Expression of Bcl-2 in Antigen-Specific Memory CD8+ T Cells1

Jason M. Grayson, Allan J. Zajac2, John D. Altman and Rafi Ahmed3

Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA

Bcl-2 plays a critical role in regulating cell survival and apoptosis. We examined Bcl-2 expression in virus-specific CD8 T cells during the expansion, death, and memory phases of the T cell response following infection of mice with lymphocytic choriomeningitis virus (LCMV). Naive CD8 T cells expressed a basal level of Bcl-2 that was down-regulated in effector CD8 T cells just before the death phase. Bcl-2 levels remained low during the death phase but surviving memory CD8 T cells expressed higher levels of Bcl-2 than naive cells. These changes were shown to occur in LCMV TCR transgenic cells as well as virus-specific CD8 T cells in C57BL/6 and BALB/c mice identified by MHC class I tetramers. In all instances, memory CD8 T cells expressed higher levels of Bcl-2, suggesting that increased Bcl-2 expression plays a role in the long-term maintenance of memory CD8 T cells in vivo.




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J. Leukoc. Biol.Home page
Y. Nakamoto, S. Kaneko, and K. Kobayashi
Increased susceptibility to apoptosis and attenuated Bcl-2 expression in T lymphocytes and monocytes from patients with advanced chronic hepatitis C
J. Leukoc. Biol., July 1, 2002; 72(1): 49 - 55.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
T. M. Onami, L. E. Harrington, M. A. Williams, M. Galvan, C. P. Larsen, T. C. Pearson, N. Manjunath, L. G. Baum, B. D. Pearce, and R. Ahmed
Dynamic Regulation of T Cell Immunity by CD43
J. Immunol., June 15, 2002; 168(12): 6022 - 6031.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
M. P. Davenport, C. Fazou, A. J. McMichael, and M. F. C. Callan
Clonal Selection, Clonal Senescence, and Clonal Succession: The Evolution of the T Cell Response to Infection with a Persistent Virus
J. Immunol., April 1, 2002; 168(7): 3309 - 3317.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
V. Appay, L. Papagno, C. A. Spina, P. Hansasuta, A. King, L. Jones, G. S. Ogg, S. Little, A. J. McMichael, D. D. Richman, et al.
Dynamics of T Cell Responses in HIV Infection
J. Immunol., April 1, 2002; 168(7): 3660 - 3666.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
J. Harbertson, E. Biederman, K. E. Bennett, R. M. Kondrack, and L. M. Bradley
Withdrawal of Stimulation May Initiate the Transition of Effector to Memory CD4 Cells
J. Immunol., February 1, 2002; 168(3): 1095 - 1102.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
T. Yajima, H. Nishimura, R. Ishimitsu, T. Watase, D. H. Busch, E. G. Pamer, H. Kuwano, and Y. Yoshikai
Overexpression of IL-15 In Vivo Increases Antigen-Driven Memory CD8+ T Cells Following a Microbe Exposure
J. Immunol., February 1, 2002; 168(3): 1198 - 1203.
[Abstract] [Full Text] [PDF]


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JEMHome page
X. Zhang, H. Fujii, H. Kishimoto, E. LeRoy, C. D. Surh, and J. Sprent
Aging Leads to Disturbed Homeostasis of Memory Phenotype CD8+ Cells
J. Exp. Med., January 28, 2002; 195(3): 283 - 293.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
S. Zhou, R. Ou, L. Huang, and D. Moskophidis
Critical Role for Perforin-, Fas/FasL-, and TNFR1-Mediated Cytotoxic Pathways in Down-Regulation of Antigen-Specific T Cells during Persistent Viral Infection
J. Virol., January 15, 2002; 76(2): 829 - 840.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
T.-S. Wu, J.-M. Lee, Y.-G. Lai, J.-C. Hsu, C.-Y. Tsai, Y.-H. Lee, and N.-S. Liao
Reduced Expression of Bcl-2 in CD8+ T Cells Deficient in the IL-15 Receptor {alpha}-Chain
J. Immunol., January 15, 2002; 168(2): 705 - 712.
[Abstract] [Full Text] [PDF]


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BloodHome page
S. Szmania, A. Galloway, M. Bruorton, P. Musk, G. Aubert, A. Arthur, H. Pyle, N. Hensel, N. Ta, L. Lamb Jr, et al.
Isolation and expansion of cytomegalovirus-specific cytotoxic T lymphocytes to clinical scale from a single blood draw using dendritic cells and HLA-tetramers
Blood, August 1, 2001; 98(3): 505 - 512.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
T. Ohteki, C. Maki, and S. Koyasu
Overexpression of Bcl-2 Differentially Restores Development of Thymus-Derived CD4-8+ T Cells and Intestinal Intraepithelial T Cells in IFN-Regulatory Factor-1-Deficient Mice
J. Immunol., June 1, 2001; 166(11): 6509 - 6513.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
E. Y. Choi, Y. Yoshimura, G. J. Christianson, T. J. Sproule, S. Malarkannan, N. Shastri, S. Joyce, and D. C. Roopenian
Quantitative Analysis of the Immune Response to Mouse Non-MHC Transplantation Antigens In Vivo: The H60 Histocompatibility Antigen Dominates Over All Others
J. Immunol., April 1, 2001; 166(7): 4370 - 4379.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
N. T. Young, M. Uhrberg, J. H. Phillips, L. L. Lanier, and P. Parham
Differential Expression of Leukocyte Receptor Complex-Encoded Ig-Like Receptors Correlates with the Transition from Effector to Memory CTL
J. Immunol., March 15, 2001; 166(6): 3933 - 3941.
[Abstract] [Full Text] [PDF]


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BloodHome page
F. J. Plunkett, M. V. D. Soares, N. Annels, A. Hislop, K. Ivory, M. Lowdell, M. Salmon, A. Rickinson, and A. N. Akbar
The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection
Blood, February 1, 2001; 97(3): 700 - 707.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
J. M. Grayson, K. Murali-Krishna, J. D. Altman, and R. Ahmed
Gene Expression in Antigen-Specific CD8+ T Cells During Viral Infection
J. Immunol., January 15, 2001; 166(2): 795 - 799.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
R. Holtappels, M.-F. Pahl-Seibert, D. Thomas, and M. J. Reddehase
Enrichment of Immediate-Early 1 (m123/pp89) Peptide-Specific CD8 T Cells in a Pulmonary CD62Llo Memory-Effector Cell Pool during Latent Murine Cytomegalovirus Infection of the Lungs
J. Virol., December 15, 2000; 74(24): 11495 - 11503.
[Abstract] [Full Text]


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BloodHome page
P. Shankar, M. Russo, B. Harnisch, M. Patterson, P. Skolnik, and J. Lieberman
Impaired function of circulating HIV-specific CD8+ T cells in chronic human immunodeficiency virus infection
Blood, November 1, 2000; 96(9): 3094 - 3101.
[Abstract] [Full Text] [PDF]


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JEMHome page
A. D. Hislop, N. E. Annels, N. H. Gudgeon, A. M. Leese, and A. B. Rickinson
Epitope-specific Evolution of Human CD8+ T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection
J. Exp. Med., April 1, 2002; 195(7): 893 - 905.
[Abstract] [Full Text] [PDF]




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