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CUTTING EDGE |
Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA
Bcl-2 plays a critical role in regulating cell survival and apoptosis. We examined Bcl-2 expression in virus-specific CD8 T cells during the expansion, death, and memory phases of the T cell response following infection of mice with lymphocytic choriomeningitis virus (LCMV). Naive CD8 T cells expressed a basal level of Bcl-2 that was down-regulated in effector CD8 T cells just before the death phase. Bcl-2 levels remained low during the death phase but surviving memory CD8 T cells expressed higher levels of Bcl-2 than naive cells. These changes were shown to occur in LCMV TCR transgenic cells as well as virus-specific CD8 T cells in C57BL/6 and BALB/c mice identified by MHC class I tetramers. In all instances, memory CD8 T cells expressed higher levels of Bcl-2, suggesting that increased Bcl-2 expression plays a role in the long-term maintenance of memory CD8 T cells in vivo.
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J. Harbertson, E. Biederman, K. E. Bennett, R. M. Kondrack, and L. M. Bradley Withdrawal of Stimulation May Initiate the Transition of Effector to Memory CD4 Cells J. Immunol., February 1, 2002; 168(3): 1095 - 1102. [Abstract] [Full Text] [PDF]
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T. Yajima, H. Nishimura, R. Ishimitsu, T. Watase, D. H. Busch, E. G. Pamer, H. Kuwano, and Y. Yoshikai Overexpression of IL-15 In Vivo Increases Antigen-Driven Memory CD8+ T Cells Following a Microbe Exposure J. Immunol., February 1, 2002; 168(3): 1198 - 1203. [Abstract] [Full Text] [PDF]
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X. Zhang, H. Fujii, H. Kishimoto, E. LeRoy, C. D. Surh, and J. Sprent Aging Leads to Disturbed Homeostasis of Memory Phenotype CD8+ Cells J. Exp. Med., January 28, 2002; 195(3): 283 - 293. [Abstract] [Full Text] [PDF]
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S. Zhou, R. Ou, L. Huang, and D. Moskophidis Critical Role for Perforin-, Fas/FasL-, and TNFR1-Mediated Cytotoxic Pathways in Down-Regulation of Antigen-Specific T Cells during Persistent Viral Infection J. Virol., January 15, 2002; 76(2): 829 - 840. [Abstract] [Full Text] [PDF]
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T.-S. Wu, J.-M. Lee, Y.-G. Lai, J.-C. Hsu, C.-Y. Tsai, Y.-H. Lee, and N.-S. Liao Reduced Expression of Bcl-2 in CD8+ T Cells Deficient in the IL-15 Receptor {alpha}-Chain J. Immunol., January 15, 2002; 168(2): 705 - 712. [Abstract] [Full Text] [PDF]
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S. Szmania, A. Galloway, M. Bruorton, P. Musk, G. Aubert, A. Arthur, H. Pyle, N. Hensel, N. Ta, L. Lamb Jr, et al. Isolation and expansion of cytomegalovirus-specific cytotoxic T lymphocytes to clinical scale from a single blood draw using dendritic cells and HLA-tetramers Blood, August 1, 2001; 98(3): 505 - 512. [Abstract] [Full Text] [PDF]
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T. Ohteki, C. Maki, and S. Koyasu Overexpression of Bcl-2 Differentially Restores Development of Thymus-Derived CD4-8+ T Cells and Intestinal Intraepithelial T Cells in IFN-Regulatory Factor-1-Deficient Mice J. Immunol., June 1, 2001; 166(11): 6509 - 6513. [Abstract] [Full Text] [PDF]
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E. Y. Choi, Y. Yoshimura, G. J. Christianson, T. J. Sproule, S. Malarkannan, N. Shastri, S. Joyce, and D. C. Roopenian Quantitative Analysis of the Immune Response to Mouse Non-MHC Transplantation Antigens In Vivo: The H60 Histocompatibility Antigen Dominates Over All Others J. Immunol., April 1, 2001; 166(7): 4370 - 4379. [Abstract] [Full Text] [PDF]
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N. T. Young, M. Uhrberg, J. H. Phillips, L. L. Lanier, and P. Parham Differential Expression of Leukocyte Receptor Complex-Encoded Ig-Like Receptors Correlates with the Transition from Effector to Memory CTL J. Immunol., March 15, 2001; 166(6): 3933 - 3941. [Abstract] [Full Text] [PDF]
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F. J. Plunkett, M. V. D. Soares, N. Annels, A. Hislop, K. Ivory, M. Lowdell, M. Salmon, A. Rickinson, and A. N. Akbar The flow cytometric analysis of telomere length in antigen-specific CD8+ T cells during acute Epstein-Barr virus infection Blood, February 1, 2001; 97(3): 700 - 707. [Abstract] [Full Text] [PDF]
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J. M. Grayson, K. Murali-Krishna, J. D. Altman, and R. Ahmed Gene Expression in Antigen-Specific CD8+ T Cells During Viral Infection J. Immunol., January 15, 2001; 166(2): 795 - 799. [Abstract] [Full Text] [PDF]
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R. Holtappels, M.-F. Pahl-Seibert, D. Thomas, and M. J. Reddehase Enrichment of Immediate-Early 1 (m123/pp89) Peptide-Specific CD8 T Cells in a Pulmonary CD62Llo Memory-Effector Cell Pool during Latent Murine Cytomegalovirus Infection of the Lungs J. Virol., December 15, 2000; 74(24): 11495 - 11503. [Abstract] [Full Text]
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P. Shankar, M. Russo, B. Harnisch, M. Patterson, P. Skolnik, and J. Lieberman Impaired function of circulating HIV-specific CD8+ T cells in chronic human immunodeficiency virus infection Blood, November 1, 2000; 96(9): 3094 - 3101. [Abstract] [Full Text] [PDF]
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A. D. Hislop, N. E. Annels, N. H. Gudgeon, A. M. Leese, and A. B. Rickinson Epitope-specific Evolution of Human CD8+ T Cell Responses from Primary to Persistent Phases of Epstein-Barr Virus Infection J. Exp. Med., April 1, 2002; 195(7): 893 - 905. [Abstract] [Full Text] [PDF]
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