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The Journal of Immunology, 2000, 164: 3919-3923.
Copyright © 2000 by The American Association of Immunologists

Protection of Nonobese Diabetic Mice from Diabetes by Gene(s) Closely Linked to IFN-{gamma} Receptor Loci1

Osami Kanagawa2, Guan Xu, Amye Tevaarwerk and Barbara A. Vaupel

Center for Immunology and Department of Pathology, Washington University School of Medicine, St. Louis, MO 63110

Nonobese diabetic (NOD) mice carrying a segment of chromosome flanking the disrupted IFN-{gamma} receptor gene from original 129 ES cells are resistant to development of diabetes. However, extended backcrossing of this mouse line to the NOD mouse resulted in a segregation of the IFN-{gamma}R-deficient genotype from the diabetes-resistant phenotype. These results indicate that the protection of NOD mice from the development of diabetes is not directly linked to the defective IFN-{gamma} receptor gene but, rather, is influenced by the presence of a diabetes-resistant gene(s) closely linked to the IFN-{gamma}R loci derived from the 129 mouse strain.




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