| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London United Kingdom
Resolution of Leishmania infection is T cell-dependent, and B lymphocytes have been considered to play a minimal role in host defense. In this study, the contribution of B lymphocytes to the response against Leishmania donovani was investigated using genetically modified IgM transmembrane domain (µMT) mutant mice, which lack mature B lymphocytes. When compared with wild-type mice, µMT mice cleared parasites more rapidly from the liver, and infection failed to establish in the spleen. The rapid clearance of parasites in µMT mice was associated with accelerated and more extensive hepatic granuloma formation compared with wild-type mice. However, the liver of infected µMT mice also showed signs of destructive pathology, associated with the presence of increased numbers of neutrophils. The role of neutrophils in controlling parasite growth in the viscera was determined by depletion with the mAb RB6-8C5. This treatment led to a dramatic enhancement of parasite growth in both the liver and spleen of µMT and wild-type mice. As assessed by transfer of both normal and chronic-infection serum, Ig protects µMT mice from destructive hepatic pathology, but minimally alters their resistance compared with wild-type mice. However, adoptive transfer of CD4+ and CD8+ T cells into recombinase activating gene 1 (RAG1-/-) recipients, suggested that T cell function was not altered by maturation in a B cell-deficient environment. Taken together, these data suggest an inhibitory role for B lymphocytes in resistance to L. donovani unrelated to the presence or absence of Ig. However, Ig protects µMT mice from the exaggerated pathology that occurs during infection.
This article has been cited by other articles:
|
|
 |
|
  C. Ronet, H. Voigt, H. Himmelrich, M.-A. Doucey, Y. Hauyon-La Torre, M. Revaz-Breton, F. Tacchini-Cottier, C. Bron, J. Louis, and P. Launois Leishmania major-Specific B Cells Are Necessary for Th2 Cell Development and Susceptibility to L. major LV39 in BALB/c Mice J. Immunol., April 1, 2008; 180(7): 4825 - 4835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. McFarlane, C. Perez, M. Charmoy, C. Allenbach, K. C. Carter, J. Alexander, and F. Tacchini-Cottier Neutrophils Contribute to Development of a Protective Immune Response during Onset of Infection with Leishmania donovani Infect. Immun., February 1, 2008; 76(2): 532 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Maglione, J. Xu, and J. Chan B Cells Moderate Inflammatory Progression and Enhance Bacterial Containment upon Pulmonary Challenge with Mycobacterium tuberculosis J. Immunol., June 1, 2007; 178(11): 7222 - 7234. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Malik, C. S. Bakshi, K. McCabe, S. V. Catlett, A. Shah, R. Singh, P. L. Jackson, A. Gaggar, D. W. Metzger, J. A. Melendez, et al. Matrix Metalloproteinase 9 Activity Enhances Host Susceptibility to Pulmonary Infection with Type A and B Strains of Francisella tularensis J. Immunol., January 15, 2007; 178(2): 1013 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. L. Allen and G. S. Deepe Jr. B Cells and CD4-CD8- T Cells Are Key Regulators of the Severity of Reactivation Histoplasmosis J. Immunol., August 1, 2006; 177(3): 1763 - 1771. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Mizoguchi and A. K. Bhan A Case for Regulatory B Cells J. Immunol., January 15, 2006; 176(2): 705 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Dondji, E. Perez-Jimenez, K. Goldsmith-Pestana, M. Esteban, and D. McMahon-Pratt Heterologous Prime-Boost Vaccination with the LACK Antigen Protects against Murine Visceral Leishmaniasis Infect. Immun., August 1, 2005; 73(8): 5286 - 5289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Casadevall and L.-a. Pirofski New Concepts in Antibody-Mediated Immunity Infect. Immun., November 1, 2004; 72(11): 6191 - 6196. [Full Text] [PDF]
|
|
|
|
 |
|
 H. Tazawa, F. Okada, T. Kobayashi, M. Tada, Y. Mori, Y. Une, F. Sendo, M. Kobayashi, and M. Hosokawa Infiltration of Neutrophils Is Required for Acquisition of Metastatic Phenotype of Benign Murine Fibrosarcoma Cells: Implication of Inflammation-Associated Carcinogenesis and Tumor Progression Am. J. Pathol., December 1, 2003; 163(6): 2221 - 2232. [Abstract] [Full Text]
|
|
|
|
|
|
C. P. Simmons, S. Clare, M. Ghaem-Maghami, T. K. Uren, J. Rankin, A. Huett, R. Goldin, D. J. Lewis, T. T. MacDonald, R. A. Strugnell, et al. Central Role for B Lymphocytes and CD4+ T Cells in Immunity to Infection by the Attaching and Effacing Pathogen Citrobacter rodentium Infect. Immun., September 1, 2003; 71(9): 5077 - 5086. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Henderson, J. A. R. Hobbs, M. Mathies, and N. Hogg Rapid recruitment of inflammatory monocytes is independent of neutrophil migration Blood, July 1, 2003; 102(1): 328 - 335. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bell and D. Gray Antigen-capturing Cells Can Masquerade as Memory B Cells J. Exp. Med., May 19, 2003; 197(10): 1233 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. R. Hobbs, R. May, K. Tanousis, E. McNeill, M. Mathies, C. Gebhardt, R. Henderson, M. J. Robinson, and N. Hogg Myeloid Cell Function in MRP-14 (S100A9) Null Mice Mol. Cell. Biol., April 1, 2003; 23(7): 2564 - 2576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Shen, J. K. Whitmire, X. Fan, D. J. Shedlock, S. M. Kaech, and R. Ahmed A Specific Role for B Cells in the Generation of CD8 T Cell Memory by Recombinant Listeria monocytogenes J. Immunol., February 1, 2003; 170(3): 1443 - 1451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Colmenares, S. L. Constant, P. E. Kima, and D. McMahon-Pratt Leishmania pifanoi Pathogenesis: Selective Lack of a Local Cutaneous Response in the Absence of Circulating Antibody Infect. Immun., December 1, 2002; 70(12): 6597 - 6605. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Buendia, L. Del Rio, N. Ortega, J. Sanchez, M. C. Gallego, M. R. Caro, J. A. Navarro, F. Cuello, and J. Salinas B-Cell-Deficient Mice Show an Exacerbated Inflammatory Response in a Model of Chlamydophila abortus Infection Infect. Immun., December 1, 2002; 70(12): 6911 - 6918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Venuprasad, P. P. Banerjee, S. Chattopadhyay, S. Sharma, S. Pal, P. B. Parab, D. Mitra, and B. Saha Human Neutrophil-Expressed CD28 Interacts with Macrophage B7 to Induce Phosphatidylinositol 3-Kinase-Dependent IFN-{gamma} Secretion and Restriction of Leishmania Growth J. Immunol., July 15, 2002; 169(2): 920 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Valenzuela, Y. Belkaid, M. K. Garfield, S. Mendez, S. Kamhawi, E. D. Rowton, D. L. Sacks, and J. M.C. Ribeiro Toward a Defined Anti-Leishmania Vaccine Targeting Vector Antigens: Characterization of a Protective Salivary Protein J. Exp. Med., August 6, 2001; 194(3): 331 - 342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. W. Murray Clinical and Experimental Advances in Treatment of Visceral Leishmaniasis Antimicrob. Agents Chemother., August 1, 2001; 45(8): 2185 - 2197. [Full Text] [PDF]
|
|
|
|
|
|
M. M. Kane and D. M. Mosser The Role of IL-10 in Promoting Disease Progression in Leishmaniasis J. Immunol., January 15, 2001; 166(2): 1141 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Bosio and K. L. Elkins Susceptibility to Secondary Francisella tularensis Live Vaccine Strain Infection in B-Cell-Deficient Mice Is Associated with Neutrophilia but Not with Defects in Specific T-Cell-Mediated Immunity Infect. Immun., January 1, 2001; 69(1): 194 - 203. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
