| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of Medicine and Immunology, University of Washington, School of Medicine, Seattle, WA 98195
High-affinity IL-2R signals are required for peripheral lymphoid homeostasis in vivo. We found that CD25 was required for regulation of peripheral T cells in mice bearing either the DO11.10 MHC class II-restricted TCR transgene or an Iaß-null mutation, suggesting that MHC class I- and class II-dependent T cell subsets are regulated independently by IL-2R signals. In contrast, deregulation of serum IgG1 levels in CD25-/- mice was dependent on CD4+ T cells. T cell expansion in DO11.10 CD25-/- mice was not preferential for cells escaping allelic exclusion by the TCR transgene, but was suppressed by a Rag-2-null mutation. Together, these findings suggest that endogenous TCR are required to trigger T cell expansion, but that CD25 regulates T cells activated by low-specificity signals. Expansion of DO11.10 T cells in response to cognate Ag was modestly reduced in CD25-/- T cells transferred into the normal lymphoid compartments of BALB/c mice. Moreover, activation-induced clonal contraction and apoptosis in vivo were intact in the absence of CD25. These data indicate that the regulatory role of high-affinity IL-2R signals extends beyond the control of Ag-specific responses and suggest a role for these signals in control of bystander T cell activation.
This article has been cited by other articles:
|
|
 |
|
  T. Yang, E. M. Wall, K. Milne, P. Theiss, P. Watson, and B. H. Nelson CD8+ T Cells Induce Complete Regression of Advanced Ovarian Cancers by an Interleukin (IL)-2/IL-15 Dependent Mechanism Clin. Cancer Res., December 1, 2007; 13(23): 7172 - 7180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Brender, G. M. Tannahill, B. J. Jenkins, J. Fletcher, R. Columbus, C. J. M. Saris, M. Ernst, N. A. Nicola, D. J. Hilton, W. S. Alexander, et al. Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27 Blood, October 1, 2007; 110(7): 2528 - 2536. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. X. Masse, E. Corcuff, H. Strick-Marchand, D. Guy-Grand, A. Tafuri-Bladt, M. L. Albert, O. Lantz, and J. P. Di Santo {gamma}c cytokines condition the progressive differentiation of CD4+ T cells PNAS, September 25, 2007; 104(39): 15442 - 15447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Dooms, K. Wolslegel, P. Lin, and A. K. Abbas Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R{alpha}-expressing cells J. Exp. Med., March 19, 2007; 204(3): 547 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. J Hayashi and O. Kanagawa Requirement of high-affinity IL-2-IL-2R interaction for T cell anergy induction Int. Immunol., May 1, 2006; 18(5): 645 - 651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Antony, C. M. Paulos, M. Ahmadzadeh, A. Akpinarli, D. C. Palmer, N. Sato, A. Kaiser, C. Heinrichs, C. A. Klebanoff, Y. Tagaya, et al. Interleukin-2-Dependent Mechanisms of Tolerance and Immunity In Vivo J. Immunol., May 1, 2006; 176(9): 5255 - 5266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jin, D. Gong, D. Adeegbe, A. L. Bayer, C. Rolle, A. Yu, and T. R. Malek Quantitative assessment concerning the contribution of IL-2R{beta} for superantigen-mediated T cell responses in vivo Int. Immunol., April 1, 2006; 18(4): 565 - 572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Burkett, R. Koka, M. Chien, S. Chai, D. L. Boone, and A. Ma Coordinate Expression and Trans Presentation of Interleukin (IL)-15R{alpha} and IL-15 Supports Natural Killer Cell and Memory CD8+ T Cell Homeostasis J. Exp. Med., October 4, 2004; 200(7): 825 - 834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. Teague, R. M. Tempero, S. Thomas, K. Murali-Krishna, and B. H. Nelson Proliferation and Differentiation of CD8+ T Cells in the Absence of IL-2/15 Receptor {beta}-Chain Expression or STAT5 Activation J. Immunol., September 1, 2004; 173(5): 3131 - 3139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Dooms, E. Kahn, B. Knoechel, and A. K. Abbas IL-2 Induces a Competitive Survival Advantage in T Lymphocytes J. Immunol., May 15, 2004; 172(10): 5973 - 5979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. Nelson IL-2, Regulatory T Cells, and Tolerance J. Immunol., April 1, 2004; 172(7): 3983 - 3988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. N. D'Souza and L. Lefrancois IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion J. Immunol., December 1, 2003; 171(11): 5727 - 5735. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Cornish, M. M. Chong, G. M. Davey, R. Darwiche, N. A. Nicola, D. J. Hilton, T. W. Kay, R. Starr, and W. S. Alexander Suppressor of Cytokine Signaling-1 Regulates Signaling in Response to Interleukin-2 and Other {gamma}c-dependent Cytokines in Peripheral T Cells J. Biol. Chem., June 13, 2003; 278(25): 22755 - 22761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. R. M. Almeida, N. Legrand, M. Papiernik, and A. A. Freitas Homeostasis of Peripheral CD4+ T Cells: IL-2R{alpha} and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers J. Immunol., November 1, 2002; 169(9): 4850 - 4860. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. N. D'Souza, K. S. Schluns, D. Masopust, and L. Lefrancois Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses J. Immunol., June 1, 2002; 168(11): 5566 - 5572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. I. Chuang, S. Morefield, C.-Y. Liu, S. Chen, J. M. Harlan, and D. M. Willerford Perturbation of B-cell development in mice overexpressing the Bcl-2 homolog A1 Blood, May 1, 2002; 99(9): 3350 - 3359. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
