The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Akashi, S.
Right arrow Articles by Miyake, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Akashi, S.
Right arrow Articles by Miyake, K.
The Journal of Immunology, 2000, 164: 3471-3475.
Copyright © 2000 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Cell Surface Expression and Lipopolysaccharide Signaling Via the Toll-Like Receptor 4-MD-2 Complex on Mouse Peritoneal Macrophages1

Sachiko Akashi*, Rintaro Shimazu*, Hirotaka Ogata*, Yoshinori Nagai*, Kiyoshi Takeda{dagger}, Masao Kimoto* and Kensuke Miyake2,*

* Department of Immunology, Saga Medical School, Nabeshima, Japan; and {dagger} Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

The human MD-2 molecule is associated with the extracellular domain of human Toll-like receptor 4 (TLR4) and greatly enhances its LPS signaling. The human TLR4-MD-2 complex thus signals the presence of LPS. Little is known, however, about cell surface expression and LPS signaling of the TLR4-MD-2 complex in vivo. We cloned mouse MD-2 molecularly and established a unique mAb MTS510, which reacted selectively with mouse TLR4-MD-2 but not with TLR4 alone in flow cytometry. Mouse MD-2 expression in TLR4-expressing cells enhanced LPS-induced NF-{kappa}B activation, which was clearly inhibited by MTS510. Thioglycolate-elicited peritoneal macrophages expressed TLR4-MD-2, which was rapidly down-regulated in the presence of LPS. Moreover, LPS-induced TNF-{alpha} production by peritoneal macrophages was inhibited by MTS510. Collectively, the TLR4-MD-2 complex is expressed on macrophages in vivo and senses and signals the presence of LPS.




This article has been cited by other articles:


Home page
 J. Leukoc. Biol.Home page
X. Liang, T. Lin, G. Sun, L. Beasley-Topliffe, J.-M. Cavaillon, and H. S. Warren
Hemopexin down-regulates LPS-induced proinflammatory cytokines from macrophages
J. Leukoc. Biol., August 1, 2009; 86(2): 229 - 235.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
R. W. Kaminski, K. R. Turbyfill, C. Chao, W. M. Ching, and E. V. Oaks
Mucosal Adjuvanticity of a Shigella Invasin Complex with DNA-Based Vaccines
Clin. Vaccine Immunol., April 1, 2009; 16(4): 574 - 586.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
L. K. Curtiss and P. S. Tobias
Emerging role of Toll-like receptors in atherosclerosis
J. Lipid Res., April 1, 2009; 50(Supplement): S340 - S345.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Yanagimoto, K. Tatsuno, S. Okugawa, T. Kitazawa, K. Tsukada, K. Koike, T. Kodama, S. Kimura, Y. Shibasaki, and Y. Ota
A Single Amino Acid of Toll-like Receptor 4 That Is Pivotal for Its Signal Transduction and Subcellular Localization
J. Biol. Chem., February 6, 2009; 284(6): 3513 - 3520.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
J. P. Nicola, M. L. Velez, A. M. Lucero, L. Fozzatti, C. G. Pellizas, and A. M. Masini-Repiso
Functional Toll-Like Receptor 4 Conferring Lipopolysaccharide Responsiveness Is Expressed in Thyroid Cells
Endocrinology, January 1, 2009; 150(1): 500 - 508.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Yvan-Charvet, C. Welch, T. A. Pagler, M. Ranalletta, M. Lamkanfi, S. Han, M. Ishibashi, R. Li, N. Wang, and A. R. Tall
Increased Inflammatory Gene Expression in ABC Transporter-Deficient Macrophages: Free Cholesterol Accumulation, Increased Signaling via Toll-Like Receptors, and Neutrophil Infiltration of Atherosclerotic Lesions
Circulation, October 28, 2008; 118(18): 1837 - 1847.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. M. Whitaker, M. Colmenares, K. G. Pestana, and D. McMahon-Pratt
Leishmania pifanoi Proteoglycolipid Complex P8 Induces Macrophage Cytokine Production through Toll-Like Receptor 4
Infect. Immun., May 1, 2008; 76(5): 2149 - 2156.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
S. M. Eswarappa, N. Basu, O. Joy, and D. Chakravortty
Folimycin (concanamycin A) inhibits LPS-induced nitric oxide production and reduces surface localization of TLR4 in murine macrophages
Innate Immunity, February 1, 2008; 14(1): 13 - 24.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
P. Rallabhandi, A. Awomoyi, K. E. Thomas, A. Phalipon, Y. Fujimoto, K. Fukase, S. Kusumoto, N. Qureshi, M. B. Sztein, and S. N. Vogel
Differential Activation of Human TLR4 by Escherichia coli and Shigella flexneri 2a Lipopolysaccharide: Combined Effects of Lipid A Acylation State and TLR4 Polymorphisms on Signaling
J. Immunol., January 15, 2008; 180(2): 1139 - 1147.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Dunn-Siegrist, O. Leger, B. Daubeuf, Y. Poitevin, F. Depis, S. Herren, M. Kosco-Vilbois, Y. Dean, J. Pugin, and G. Elson
Pivotal Involvement of Fc{gamma} Receptor IIA in the Neutralization of Lipopolysaccharide Signaling via a Potent Novel Anti-TLR4 Monoclonal Antibody 15C1
J. Biol. Chem., November 30, 2007; 282(48): 34817 - 34827.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Daubeuf, J. Mathison, S. Spiller, S. Hugues, S. Herren, W. Ferlin, M. Kosco-Vilbois, H. Wagner, C. J. Kirschning, R. Ulevitch, et al.
TLR4/MD-2 Monoclonal Antibody Therapy Affords Protection in Experimental Models of Septic Shock
J. Immunol., November 1, 2007; 179(9): 6107 - 6114.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. E. M. El Shikh, R. M. El Sayed, Y. Wu, A. K. Szakal, and J. G. Tew
TLR4 on Follicular Dendritic Cells: An Activation Pathway That Promotes Accessory Activity
J. Immunol., October 1, 2007; 179(7): 4444 - 4450.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Divanovic, A. Trompette, L. K. Petiniot, J. L. Allen, L. M. Flick, Y. Belkaid, R. Madan, J. J. Haky, and C. L. Karp
Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105
J. Leukoc. Biol., August 1, 2007; 82(2): 265 - 271.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. M.L. Tsukumo, M. A. Carvalho-Filho, J. B.C. Carvalheira, P. O. Prada, S. M. Hirabara, A. A. Schenka, E. P. Araujo, J. Vassallo, R. Curi, L. A. Velloso, et al.
Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance
Diabetes, August 1, 2007; 56(8): 1986 - 1998.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. T. Figueiredo, P. L. Fernandez, D. S. Mourao-Sa, B. N. Porto, F. F. Dutra, L. S. Alves, M. F. Oliveira, P. L. Oliveira, A. V. Graca-Souza, and M. T. Bozza
Characterization of Heme as Activator of Toll-like Receptor 4
J. Biol. Chem., July 13, 2007; 282(28): 20221 - 20229.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. Suzuki, Y. Sugimoto, Y. Ohsaki, M. Ueno, S. Kato, Y. Kitamura, H. Hosokawa, J. P. Davies, Y. A. Ioannou, M. T. Vanier, et al.
Endosomal Accumulation of Toll-Like Receptor 4 Causes Constitutive Secretion of Cytokines and Activation of Signal Transducers and Activators of Transcription in Niemann-Pick Disease Type C (NPC) Fibroblasts: A Potential Basis for Glial Cell Activation in the NPC Brain
J. Neurosci., February 21, 2007; 27(8): 1879 - 1891.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
A. A. Quintar, F. D. Roth, A. L. D. Paul, A. Aoki, and C. A. Maldonado
Toll-Like Receptor 4 in Rat Prostate: Modulation by Testosterone and Acute Bacterial Infection in Epithelial and Stromal Cells
Biol Reprod, November 1, 2006; 75(5): 664 - 672.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
S. Ohta, U. Bahrun, R. Shimazu, H. Matsushita, K. Fukudome, and M. Kimoto
Induction of Long-Term Lipopolysaccharide Tolerance by an Agonistic Monoclonal Antibody to the Toll-Like Receptor 4/MD-2 Complex
Clin. Vaccine Immunol., October 1, 2006; 13(10): 1131 - 1136.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. M. Buckley, J. H. Wang, and H. P. Redmond
Cellular reprogramming by gram-positive bacterial components: a review
J. Leukoc. Biol., October 1, 2006; 80(4): 731 - 741.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Rodo, L. A. Goncalves, J. Demengeot, A. Coutinho, and C. Penha-Goncalves
MHC Class II Molecules Control Murine B Cell Responsiveness to Lipopolysaccharide Stimulation
J. Immunol., October 1, 2006; 177(7): 4620 - 4626.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
C. H. Cook, J. Trgovcich, P. D. Zimmerman, Y. Zhang, and D. D. Sedmak
Lipopolysaccharide, Tumor Necrosis Factor Alpha, or Interleukin-1{beta} Triggers Reactivation of Latent Cytomegalovirus in Immunocompetent Mice.
J. Virol., September 1, 2006; 80(18): 9151 - 9158.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
Y. Wakabayashi, M. Kobayashi, S. Akashi-Takamura, N. Tanimura, K. Konno, K. Takahashi, T. Ishii, T. Mizutani, H. Iba, T. Kouro, et al.
A Protein Associated with Toll-Like Receptor 4 (PRAT4A) Regulates Cell Surface Expression of TLR4
J. Immunol., August 1, 2006; 177(3): 1772 - 1779.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Sanchez-Tillo, M. Comalada, C. Farrera, A. F. Valledor, J. Lloberas, and A. Celada
Macrophage-Colony-Stimulating Factor-Induced Proliferation and Lipopolysaccharide-Dependent Activation of Macrophages Requires Raf-1 Phosphorylation to Induce Mitogen Kinase Phosphatase-1 Expression.
J. Immunol., June 1, 2006; 176(11): 6594 - 6602.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Kobayashi, S.-i. Saitoh, N. Tanimura, K. Takahashi, K. Kawasaki, M. Nishijima, Y. Fujimoto, K. Fukase, S. Akashi-Takamura, and K. Miyake
Regulatory Roles for MD-2 and TLR4 in Ligand-Induced Receptor Clustering
J. Immunol., May 15, 2006; 176(10): 6211 - 6218.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. A. Khan, C. Ma, L. A. Knodler, Y. Valdez, C. M. Rosenberger, W. Deng, B. B. Finlay, and B. A. Vallance
Toll-Like Receptor 4 Contributes to Colitis Development but Not to Host Defense during Citrobacter rodentium Infection in Mice.
Infect. Immun., May 1, 2006; 74(5): 2522 - 2536.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Viriyakosol, P. S. Tobias, and T. N. Kirkland
Mutational Analysis of Membrane and Soluble Forms of Human MD-2
J. Biol. Chem., April 28, 2006; 281(17): 11955 - 11964.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
F.-S. X. Yu and L. D. Hazlett
Toll-like Receptors and the Eye.
Invest. Ophthalmol. Vis. Sci., April 1, 2006; 47(4): 1255 - 1263.
[Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
C. H. Li, J. H. Wang, and H. P. Redmond
Bacterial lipoprotein-induced self-tolerance and cross-tolerance to LPS are associated with reduced IRAK-1 expression and MyD88-IRAK complex formation
J. Leukoc. Biol., April 1, 2006; 79(4): 867 - 875.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
R. Zhou, S.-X. Zheng, W. Tang, P.-L. He, X.-Y. Li, Y.-F. Yang, Y.-C. Li, J.-G. Geng, and J.-P. Zuo
Inhibition of Inducible Nitric-Oxide Synthase Expression by (5R)-5-Hydroxytriptolide in Interferon-{gamma}- and Bacterial Lipopolysaccharide-Stimulated Macrophages
J. Pharmacol. Exp. Ther., January 1, 2006; 316(1): 121 - 128.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
S. Divanovic, A. Trompette, S. F. Atabani, R. Madan, D. T. Golenbock, A. Visintin, R. W. Finberg, A. Tarakhovsky, S. N. Vogel, Y. Belkaid, et al.
Inhibition of TLR-4/MD-2 signaling by RP105/MD-1
Innate Immunity, December 1, 2005; 11(6): 363 - 368.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
H.-Y. Qi and J. H. Shelhamer
Toll-like Receptor 4 Signaling Regulates Cytosolic Phospholipase A2 Activation and Lipid Generation in Lipopolysaccharide-stimulated Macrophages
J. Biol. Chem., November 25, 2005; 280(47): 38969 - 38975.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. W. Askenase, A. Itakura, M. C. Leite-de-Moraes, M. Lisbonne, S. Roongapinun, D. R. Goldstein, and M. Szczepanik
TLR-Dependent IL-4 Production by Invariant V{alpha}14+J{alpha}18+ NKT Cells to Initiate Contact Sensitivity In Vivo
J. Immunol., November 15, 2005; 175(10): 6390 - 6401.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. R. Coats, T.-T. T. Pham, B. W. Bainbridge, R. A. Reife, and R. P. Darveau
MD-2 Mediates the Ability of Tetra-Acylated and Penta-Acylated Lipopolysaccharides to Antagonize Escherichia coli Lipopolysaccharide at the TLR4 Signaling Complex
J. Immunol., October 1, 2005; 175(7): 4490 - 4498.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
T. V. Pedchenko, G. Y. Park, M. Joo, T. S. Blackwell, and J. W. Christman
Inducible binding of PU.1 and interacting proteins to the Toll-like receptor 4 promoter during endotoxemia
Am J Physiol Lung Cell Mol Physiol, September 1, 2005; 289(3): L429 - L437.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
K. Brandl, T. Gluck, P. Hartmann, B. Salzberger, and W. Falk
A designed TLR4/MD-2 complex to capture LPS
Innate Immunity, August 1, 2005; 11(4): 197 - 206.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
J. D. Savov, D. M. Brass, B. L. Lawson, E. McElvania-Tekippe, J. K. L. Walker, and D. A. Schwartz
Toll-like receptor 4 antagonist (E5564) prevents the chronic airway response to inhaled lipopolysaccharide
Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L329 - L337.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
D. Huugen, H. Xiao, A. van Esch, R. J. Falk, C. J. Peutz-Kootstra, W. A. Buurman, J. W. C. Tervaert, J. C. Jennette, and P. Heeringa
Aggravation of Anti-Myeloperoxidase Antibody-Induced Glomerulonephritis by Bacterial Lipopolysaccharide: Role of Tumor Necrosis Factor-{alpha}
Am. J. Pathol., July 1, 2005; 167(1): 47 - 58.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
R. L. Chelvarajan, S. M. Collins, J. M. Van Willigen, and S. Bondada
The unresponsiveness of aged mice to polysaccharide antigens is a result of a defect in macrophage function
J. Leukoc. Biol., April 1, 2005; 77(4): 503 - 512.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Jeyaseelan, H. W. Chu, S. K. Young, M. W. Freeman, and G. S. Worthen
Distinct Roles of Pattern Recognition Receptors CD14 and Toll-Like Receptor 4 in Acute Lung Injury
Infect. Immun., March 1, 2005; 73(3): 1754 - 1763.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
P. Tobias and L. K. Curtiss
Thematic review series: The Immune System and Atherogenesis. Paying the price for pathogen protection: toll receptors in atherogenesis
J. Lipid Res., March 1, 2005; 46(3): 404 - 411.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Preciado, E. Caicedo, R. Jhanjee, R. Silver, G. Harris, S. K. Juhn, D. I. Choo, and F. Ondrey
Pseudomonas aeruginosa Lipopolysaccharide Induction of Keratinocyte Proliferation, NF-{kappa}B, and Cyclin D1 Is Inhibited by Indomethacin
J. Immunol., March 1, 2005; 174(5): 2964 - 2973.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. De Creus, M. Abe, A. H. Lau, H. Hackstein, G. Raimondi, and A. W. Thomson
Low TLR4 Expression by Liver Dendritic Cells Correlates with Reduced Capacity to Activate Allogeneic T Cells in Response to Endotoxin
J. Immunol., February 15, 2005; 174(4): 2037 - 2045.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
M. Triantafilou and K. Triantafilou
Invited review: The dynamics of LPS recognition: complex orchestration of multiple receptors
Innate Immunity, February 1, 2005; 11(1): 5 - 11.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
G. C. O'Brien, J. H. Wang, and H. P. Redmond
Bacterial Lipoprotein Induces Resistance to Gram-Negative Sepsis in TLR4-Deficient Mice via Enhanced Bacterial Clearance
J. Immunol., January 15, 2005; 174(2): 1020 - 1026.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
K. Takeda and S. Akira
Toll-like receptors in innate immunity
Int. Immunol., January 1, 2005; 17(1): 1 - 14.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. Pugin, S. Stern-Voeffray, B. Daubeuf, M. A. Matthay, G. Elson, and I. Dunn-Siegrist
Soluble MD-2 activity in plasma from patients with severe sepsis and septic shock
Blood, December 15, 2004; 104(13): 4071 - 4079.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Nilsen, U. Nonstad, N. Khan, C. F. Knetter, S. Akira, A. Sundan, T. Espevik, and E. Lien
Lipopolysaccharide and Double-stranded RNA Up-regulate Toll-like Receptor 2 Independently of Myeloid Differentiation Factor 88
J. Biol. Chem., September 17, 2004; 279(38): 39727 - 39735.
[Abstract] [Full Text] [PDF]

Home page
 JDRHome page
F.H. Nociti Jr., B.L. Foster, S.P. Barros, R.P. Darveau, and M.J. Somerman
Cementoblast Gene Expression is Regulated by Porphyromonas gingivalis Lipopolysaccharide Partially via Toll-like Receptor-4/MD-2
Journal of Dental Research, August 1, 2004; 83(8): 602 - 607.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Punturieri, R. S. Alviani, T. Polak, P. Copper, J. Sonstein, and J. L. Curtis
Specific Engagement of TLR4 or TLR3 Does Not Lead to IFN-{beta}-Mediated Innate Signal Amplification and STAT1 Phosphorylation in Resident Murine Alveolar Macrophages
J. Immunol., July 15, 2004; 173(2): 1033 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Ishihara, M. A. K. Rumi, Y. Kadowaki, C. F. Ortega-Cava, T. Yuki, N. Yoshino, Y. Miyaoka, H. Kazumori, N. Ishimura, Y. Amano, et al.
Essential Role of MD-2 in TLR4-Dependent Signaling during Helicobacter pylori-Associated Gastritis
J. Immunol., July 15, 2004; 173(2): 1406 - 1416.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Matsushima, N. Yamada, H. Matsue, and S. Shimada
TLR3-, TLR7-, and TLR9-Mediated Production of Proinflammatory Cytokines and Chemokines from Murine Connective Tissue Type Skin-Derived Mast Cells but Not from Bone Marrow-Derived Mast Cells
J. Immunol., July 1, 2004; 173(1): 531 - 541.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
S.-i. Saitoh, S. Akashi, T. Yamada, N. Tanimura, M. Kobayashi, K. Konno, F. Matsumoto, K. Fukase, S. Kusumoto, Y. Nagai, et al.
Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization
Int. Immunol., July 1, 2004; 16(7): 961 - 969.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
R. L. Chelvarajan, S. M. Collins, I. E. Doubinskaia, S. Goes, J. Van Willigen, D. Flanagan, W. J. S. de Villiers, J. S. Bryson, and S. Bondada
Defective macrophage function in neonates and its impact on unresponsiveness of neonates to polysaccharide antigens
J. Leukoc. Biol., June 1, 2004; 75(6): 982 - 994.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
M. Okamoto, G. Oh-e, T. Oshikawa, S. Furuichi, T. Tano, S. U. Ahmed, S. Akashi, K. Miyake, O. Takeuchi, S. Akira, et al.
Toll-Like Receptor 4 Mediates the Antitumor Host Response Induced by a 55-Kilodalton Protein Isolated from Aeginetia indica L., a Parasitic Plant
Clin. Vaccine Immunol., May 1, 2004; 11(3): 483 - 495.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. Kato, Y. Yuzawa, N. Tsuboi, S. Maruyama, Y. Morita, T. Matsuguchi, and S. Matsuo
Endotoxin-Induced Chemokine Expression in Murine Peritoneal Mesothelial Cells: The Role of Toll-Like Receptor 4
J. Am. Soc. Nephrol., May 1, 2004; 15(5): 1289 - 1299.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
K. A. Ryan, M. F. Smith Jr., M. K. Sanders, and P. B. Ernst
Reactive Oxygen and Nitrogen Species Differentially Regulate Toll-Like Receptor 4-Mediated Activation of NF-{kappa}B and Interleukin-8 Expression
Infect. Immun., April 1, 2004; 72(4): 2123 - 2130.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. S. Weiss, B. Raupach, K. Takeda, S. Akira, and A. Zychlinsky
Toll-Like Receptors Are Temporally Involved in Host Defense
J. Immunol., April 1, 2004; 172(7): 4463 - 4469.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. L. Gioannini, A. Teghanemt, D. Zhang, N. P. Coussens, W. Dockstader, S. Ramaswamy, and J. P. Weiss
Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations
PNAS, March 23, 2004; 101(12): 4186 - 4191.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Andreakos, S. M. Sacre, C. Smith, A. Lundberg, S. Kiriakidis, T. Stonehouse, C. Monaco, M. Feldmann, and B. M. Foxwell
Distinct pathways of LPS-induced NF-{kappa}B activation and cytokine production in human myeloid and nonmyeloid cells defined by selective utilization of MyD88 and Mal/TIRAP
Blood, March 15, 2004; 103(6): 2229 - 2237.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Shiratsuchi, I. Watanabe, O. Takeuchi, S. Akira, and Y. Nakanishi
Inhibitory Effect of Toll-Like Receptor 4 on Fusion between Phagosomes and Endosomes/Lysosomes in Macrophages
J. Immunol., February 15, 2004; 172(4): 2039 - 2047.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
S. H. Kim, V. J. Johnson, T.-Y. Shin, and R. P. Sharma
Selenium Attenuates Lipopolysaccharide-Induced Oxidative Stress Responses Through Modulation of p38 MAPK and NF-{kappa}B Signaling Pathways
Experimental Biology and Medicine, February 1, 2004; 229(2): 203 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
R. K. Ernst, A. M. Hajjar, J. H. Tsai, S. M. Moskowitz, C. B. Wilson, and S. I. Miller
Pseudomonas aeruginosa lipid A diversity and its recognition by Toll-like receptor 4
Innate Immunity, December 1, 2003; 9(6): 395 - 400.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
F. Re and J. L. Strominger
Separate Functional Domains of Human MD-2 Mediate Toll-Like Receptor 4-Binding and Lipopolysaccharide Responsiveness
J. Immunol., November 15, 2003; 171(10): 5272 - 5276.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Hashimoto, Y. Asai, and T. Ogawa
Treponemal Phospholipids Inhibit Innate Immune Responses Induced by Pathogen-associated Molecular Patterns
J. Biol. Chem., November 7, 2003; 278(45): 44205 - 44213.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
M. W. Hornef, B. H. Normark, A. Vandewalle, and S. Normark
Intracellular Recognition of Lipopolysaccharide by Toll-like Receptor 4 in Intestinal Epithelial Cells
J. Exp. Med., October 20, 2003; 198(8): 1225 - 1235.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. Akashi, S.-i. Saitoh, Y. Wakabayashi, T. Kikuchi, N. Takamura, Y. Nagai, Y. Kusumoto, K. Fukase, S. Kusumoto, Y. Adachi, et al.
Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2: Higher Affinity than That with MD-2 or CD14
J. Exp. Med., October 6, 2003; 198(7): 1035 - 1042.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
K. Kawasaki, K. Gomi, Y. Kawai, M. Shiozaki, and M. Nishijima
Molecular basis for lipopolysaccharide mimetic action of TaxolTM and flavolipin
Innate Immunity, October 1, 2003; 9(5): 301 - 307.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
S. C. Higgins, E. C. Lavelle, C. McCann, B. Keogh, E. McNeela, P. Byrne, B. O'Gorman, A. Jarnicki, P. McGuirk, and K. H. G. Mills
Toll-Like Receptor 4-Mediated Innate IL-10 Activates Antigen-Specific Regulatory T Cells and Confers Resistance to Bordetella pertussis by Inhibiting Inflammatory Pathology
J. Immunol., September 15, 2003; 171(6): 3119 - 3127.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. M. Paterson, T. J. Murphy, E. J. Purcell, O. Shelley, S. J. Kriynovich, E. Lien, J. A. Mannick, and J. A. Lederer
Injury Primes the Innate Immune System for Enhanced Toll-Like Receptor Reactivity
J. Immunol., August 1, 2003; 171(3): 1473 - 1483.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Qureshi, P.-Y. Perera, J. Shen, G. Zhang, A. Lenschat, G. Splitter, D. C. Morrison, and S. N. Vogel
The Proteasome as a Lipopolysaccharide-Binding Protein in Macrophages: Differential Effects of Proteasome Inhibition on Lipopolysaccharide-Induced Signaling Events
J. Immunol., August 1, 2003; 171(3): 1515 - 1525.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Okugawa, Y. Ota, T. Kitazawa, K. Nakayama, S. Yanagimoto, K. Tsukada, M. Kawada, and S. Kimura
Janus kinase 2 is involved in lipopolysaccharide-induced activation of macrophages
Am J Physiol Cell Physiol, August 1, 2003; 285(2): C399 - C408.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. E. O. Baleeiro, S. E. Wilcoxen, S. B. Morris, T. J. Standiford, and R. Paine III
Sublethal Hyperoxia Impairs Pulmonary Innate Immunity
J. Immunol., July 15, 2003; 171(2): 955 - 963.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
D. Dory, H. Echchannaoui, M. Letiembre, F. Ferracin, J. Pieters, Y. Adachi, S. Akashi, W. Zimmerli, and R. Landmann
Generation and functional characterization of a clonal murine periportal Kupffer cell line from H-2Kb -tsA58 mice
J. Leukoc. Biol., July 1, 2003; 74(1): 49 - 59.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Bihl, L. Salez, M. Beaubier, D. Torres, L. Lariviere, L. Laroche, A. Benedetto, D. Martel, J.-M. Lapointe, B. Ryffel, et al.
Overexpression of Toll-Like Receptor 4 Amplifies the Host Response to Lipopolysaccharide and Provides a Survival Advantage in Transgenic Mice
J. Immunol., June 15, 2003; 170(12): 6141 - 6150.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
R. Tamai, S. Sugawara, O. Takeuchi, S. Akira, and H. Takada
Synergistic effects of lipopolysaccharide and interferon-{gamma} in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression
Innate Immunity, June 1, 2003; 9(3): 145 - 153.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
T. Pedron, R. Girard, and R. Chaby
TLR4-dependent Lipopolysaccharide-induced Shedding of Tumor Necrosis Factor Receptors in Mouse Bone Marrow Granulocytes
J. Biol. Chem., May 30, 2003; 278(23): 20555 - 20564.
[Abstract] [Full Text] [PDF]

Home page
 CVIHome page
T. Ohnishi, M. Muroi, and K.-i. Tanamoto
MD-2 Is Necessary for the Toll-Like Receptor 4 Protein To Undergo Glycosylation Essential for Its Translocation to the Cell Surface
Clin. Vaccine Immunol., May 1, 2003; 10(3): 405 - 410.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. F. Ortega-Cava, S. Ishihara, M. A. K. Rumi, K. Kawashima, N. Ishimura, H. Kazumori, J. Udagawa, Y. Kadowaki, and Y. Kinoshita
Strategic Compartmentalization of Toll-Like Receptor 4 in the Mouse Gut
J. Immunol., April 15, 2003; 170(8): 3977 - 3985.
[Abstract] [Full Text] [PDF]

Home page
 Innate ImmunityHome page
T. Roger, C. Froidevaux, C. Martin, and T. Calandra
Macrophage migration inhibitory factor (MIF) regulates host responses to endotoxin through modulation of Toll-like receptor 4 (TLR4)
Innate Immunity, April 1, 2003; 9(2): 119 - 123.
[Abstract] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
M. Okamoto, T. Oshikawa, T. Tano, G. Ohe, S. Furuichi, H. Nishikawa, S. U. Ahmed, S. Akashi, K. Miyake, O. Takeuchi, et al.
Involvement of Toll-Like Receptor 4 Signaling in Interferon-{gamma} Production and Antitumor Effect by Streptococcal Agent OK-432
J Natl Cancer Inst, February 19, 2003; 95(4): 316 - 326.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
I. Caramalho, T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot
Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide
J. Exp. Med., February 17, 2003; 197(4): 403 - 411.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
L. A. Augusto, M. Synguelakis, J. Johansson, T. Pedron, R. Girard, and R. Chaby
Interaction of Pulmonary Surfactant Protein C with CD14 and Lipopolysaccharide
Infect. Immun., January 1, 2003; 71(1): 61 - 67.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kawasaki, H. Nogawa, and M. Nishijima
Identification of Mouse MD-2 Residues Important for Forming the Cell Surface TLR4-MD-2 Complex Recognized by Anti-TLR4-MD-2 Antibodies, and for Conferring LPS and Taxol Responsiveness on Mouse TLR4 by Alanine-Scanning Mutagenesis
J. Immunol., January 1, 2003; 170(1): 413 - 420.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. L. Gioannini, D. Zhang, A. Teghanemt, and J. P. Weiss
An Essential Role for Albumin in the Interaction of Endotoxin with Lipopolysaccharide-binding Protein and sCD14 and Resultant Cell Activation
J. Biol. Chem., November 27, 2002; 277(49): 47818 - 47825.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. Yamamoto, T. Shimokawa, H. Yi, K.-i. Isobe, T. Kojima, D. J. Loskutoff, and H. Saito
Aging Accelerates Endotoxin-Induced Thrombosis : Increased Responses of Plasminogen Activator Inhibitor-1 and Lipopolysaccharide Signaling with Aging
Am. J. Pathol., November 1, 2002; 161(5): 1805 - 1814.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Tsuboi, Y. Yoshikai, S. Matsuo, T. Kikuchi, K.-I. Iwami, Y. Nagai, O. Takeuchi, S. Akira, and T. Matsuguchi
Roles of Toll-Like Receptors in C-C Chemokine Production by Renal Tubular Epithelial Cells
J. Immunol., August 15, 2002; 169(4): 2026 - 2033.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
A. UEHARA, S. SUGAWARA, and H. TAKADA
Priming of human oral epithelial cells by interferon-{gamma} to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans
J. Med. Microbiol., August 1, 2002; 51(8): 626 - 634.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. B. Mizel and J. A. Snipes
Gram-negative Flagellin-induced Self-tolerance Is Associated with a Block in Interleukin-1 Receptor-associated Kinase Release from Toll-like Receptor 5
J. Biol. Chem., June 14, 2002; 277(25): 22414 - 22420.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Fan, A. Kapus, P. A. Marsden, Y. H. Li, G. Oreopoulos, J. C. Marshall, S. Frantz, R. A. Kelly, R. Medzhitov, and O. D. Rotstein
Regulation of Toll-Like Receptor 4 Expression in the Lung Following Hemorrhagic Shock and Lipopolysaccharide
J. Immunol., May 15, 2002; 168(10): 5252 - 5259.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
S. Li, V. M. Holers, S. A. Boackle, and C. M. Blatteis
Modulation of Mouse Endotoxic Fever by Complement
Infect. Immun., May 1, 2002; 70(5): 2519 - 2525.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
N. Tuaillon, D. F. Shen, R. B. Berger, B. Lu, B. J. Rollins, and C.-C. Chan
MCP-1 Expression in Endotoxin-Induced Uveitis
Invest. Ophthalmol. Vis. Sci., May 1, 2002; 43(5): 1493 - 1498.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Dabbagh, M. E. Dahl, P. Stepick-Biek, and D. B. Lewis
Toll-Like Receptor 4 Is Required for Optimal Development of Th2 Immune Responses: Role of Dendritic Cells
J. Immunol., May 1, 2002; 168(9): 4524 - 4530.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Gomi, K. Kawasaki, Y. Kawai, M. Shiozaki, and M. Nishijima
Toll-Like Receptor 4-MD-2 Complex Mediates the Signal Transduction Induced by Flavolipin, an Amino Acid-Containing Lipid Unique to Flavobacterium meningosepticum
J. Immunol., March 15, 2002; 168(6): 2939 - 2943.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. J. Watters, J. A. Sommer, Z. A. Pfeiffer, U. Prabhu, A. N. Guerra, and P. J. Bertics
A Differential Role for the Mitogen-activated Protein Kinases in Lipopolysaccharide Signaling. THE MEK/ERK PATHWAY IS NOT ESSENTIAL FOR NITRIC OXIDE AND INTERLEUKIN 1beta PRODUCTION
J. Biol. Chem., March 8, 2002; 277(11): 9077 - 9087.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
T. Vasselon and P. A. Detmers
Toll Receptors: a Central Element in Innate Immune Responses
Infect. Immun., March 1, 2002; 70(3): 1033 - 1041.
[Full Text] [PDF]

Home page
 Infect. Immun.Home page
R. Tamai, T. Sakuta, K. Matsushita, M. Torii, O. Takeuchi, S. Akira, S. Akashi, T. Espevik, S. Sugawara, and H. Takada
Human Gingival CD14+ Fibroblasts Primed with Gamma Interferon Increase Production of Interleukin-8 in Response to Lipopolysaccharide through Up-Regulation of Membrane CD14 and MyD88 mRNA Expression
Infect. Immun., March 1, 2002; 70(3): 1272 - 1278.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Iovine, J. Eastvold, P. Elsbach, J. P. Weiss, and T. L. Gioannini
The Carboxyl-terminal Domain of Closely Related Endotoxin-binding Proteins Determines the Target of Protein-Lipopolysaccharide Complexes
J. Biol. Chem., March 1, 2002; 277(10): 7970 - 7978.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. N. Fichorova, A. O. Cronin, E. Lien, D. J. Anderson, and R. R. Ingalls
Response to Neisseria gonorrhoeae by Cervicovaginal Epithelial Cells Occurs in the Absence of Toll-Like Receptor 4-Mediated Signaling
J. Immunol., March 1, 2002; 168(5): 2424 - 2432.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.