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CUTTING EDGE |
*
DNAX Research Institute, Palo Alto, CA 94304;
Department of Dermatology, University of Düsseldorf, Düsseldorf, Germany;
Schering Plough, Laboratory for Immunological Research, Dardilly, France; and
§
Instituto Nacional de la Nutrición Salvador Zubirán, México City, México
We recently reported the identification of a chemokine (CTACK),
which has been renamed CCL27 according to a new systematic chemokine
nomenclature. We report that CCL27 binds the previously orphan
chemokine receptor GPR-2, as detected by calcium flux and chemotactic
responses of GPR-2 transfectants. We renamed this receptor CCR10.
Because of the skin-associated expression pattern of CCL27, we focused
on the expression of CCL27 and CCR10 in normal skin compared with
inflammatory and autoimmune skin diseases. CCL27 is constitutively
produced by keratinocytes but can also be induced upon stimulation with
TNF-
and IL-1ß. CCR10 is not expressed by keratinocytes and is
instead expressed by melanocytes, dermal fibroblasts, and dermal
microvascular endothelial cells. CCR10 was also detected in T cells as
well as in skin-derived Langerhans cells. Taken together, these
observations suggest a role for this novel ligand/receptor pair in both
skin homeostasis as well as a potential role in inflammatory
responses.
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