|
|
||||||||
CUTTING EDGE |




*
DNAX Research Institute, Palo Alto, CA 94304;
Department of Dermatology, University of Düsseldorf, Düsseldorf, Germany;
Schering Plough, Laboratory for Immunological Research, Dardilly, France; and
§
Instituto Nacional de la Nutrición Salvador Zubirán, México City, México
We recently reported the identification of a chemokine (CTACK),
which has been renamed CCL27 according to a new systematic chemokine
nomenclature. We report that CCL27 binds the previously orphan
chemokine receptor GPR-2, as detected by calcium flux and chemotactic
responses of GPR-2 transfectants. We renamed this receptor CCR10.
Because of the skin-associated expression pattern of CCL27, we focused
on the expression of CCL27 and CCR10 in normal skin compared with
inflammatory and autoimmune skin diseases. CCL27 is constitutively
produced by keratinocytes but can also be induced upon stimulation with
TNF-
and IL-1ß. CCR10 is not expressed by keratinocytes and is
instead expressed by melanocytes, dermal fibroblasts, and dermal
microvascular endothelial cells. CCR10 was also detected in T cells as
well as in skin-derived Langerhans cells. Taken together, these
observations suggest a role for this novel ligand/receptor pair in both
skin homeostasis as well as a potential role in inflammatory
responses.
This article has been cited by other articles:
![]() |
A.-K. Shirakawa, D. Nagakubo, K. Hieshima, T. Nakayama, Z. Jin, and O. Yoshie 1,25-Dihydroxyvitamin D3 Induces CCR10 Expression in Terminally Differentiating Human B Cells J. Immunol., March 1, 2008; 180(5): 2786 - 2795. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Pivarcsi, A. Muller, A. Hippe, J. Rieker, A. van Lierop, M. Steinhoff, S. Seeliger, R. Kubitza, U. Pippirs, S. Meller, et al. Tumor immune escape by the loss of homeostatic chemokine expression PNAS, November 27, 2007; 104(48): 19055 - 19060. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Yoon, Z. Liang, X. Zhang, M. Choe, A. Zhu, H. T. Cho, D. M. Shin, M. M. Goodman, Z. Chen, and H. Shim CXC Chemokine Receptor-4 Antagonist Blocks Both Growth of Primary Tumor and Metastasis of Head and Neck Cancer in Xenograft Mouse Models Cancer Res., August 1, 2007; 67(15): 7518 - 7524. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. J. Campbell, D. J. O'Connell, and M.-A. Wurbel Cutting Edge: Chemokine Receptor CCR4 Is Necessary for Antigen-Driven Cutaneous Accumulation of CD4 T Cells under Physiological Conditions J. Immunol., March 15, 2007; 178(6): 3358 - 3362. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Chen, S.-x. Lin, R. Agha-Majzoub, L. Overbergh, C. Mathieu, and L. S. Chan CCL27 is a critical factor for the development of atopic dermatitis in the keratin-14 IL-4 transgenic mouse model Int. Immunol., August 1, 2006; 18(8): 1233 - 1242. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Kakinuma and S. T. Hwang Chemokines, chemokine receptors, and cancer metastasis J. Leukoc. Biol., April 1, 2006; 79(4): 639 - 651. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. M. Ebert, S. Meuter, and B. Moser Homing and Function of Human Skin {gamma}{delta} T Cells and NK Cells: Relevance for Tumor Surveillance J. Immunol., April 1, 2006; 176(7): 4331 - 4336. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. C. Jenmalm, H. Cherwinski, E. P. Bowman, J. H. Phillips, and J. D. Sedgwick Regulation of Myeloid Cell Function through the CD200 Receptor J. Immunol., January 1, 2006; 176(1): 191 - 199. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. A. Wysocki, A. Panoskaltsis-Mortari, B. R. Blazar, and J. S. Serody Leukocyte migration and graft-versus-host disease Blood, June 1, 2005; 105(11): 4191 - 4199. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Gombert, M.-C. Dieu-Nosjean, F. Winterberg, E. Bunemann, R. C. Kubitza, L. Da Cunha, A. Haahtela, S. Lehtimaki, A. Muller, J. Rieker, et al. CCL1-CCR8 Interactions: An Axis Mediating the Recruitment of T Cells and Langerhans-Type Dendritic Cells to Sites of Atopic Skin Inflammation J. Immunol., April 15, 2005; 174(8): 5082 - 5091. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Hirata, Y. Furukawa, B.-G. Yang, K. Hieshima, M. Fukuda, R. Kannagi, O. Yoshie, and M. Miyasaka Human P-selectin Glycoprotein Ligand-1 (PSGL-1) Interacts with the Skin-associated Chemokine CCL27 via Sulfated Tyrosines at the PSGL-1 Amino Terminus J. Biol. Chem., December 10, 2004; 279(50): 51775 - 51782. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Pivarcsi, M. Gombert, M.-C. Dieu-Nosjean, A. Lauerma, R. Kubitza, S. Meller, J. Rieker, A. Muller, L. Da Cunha, A. Haahtela, et al. CC Chemokine Ligand 18, An Atopic Dermatitis-Associated and Dendritic Cell-Derived Chemokine, Is Regulated by Staphylococcal Products and Allergen Exposure J. Immunol., November 1, 2004; 173(9): 5810 - 5817. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Hieshima, Y. Kawasaki, H. Hanamoto, T. Nakayama, D. Nagakubo, A. Kanamaru, and O. Yoshie CC Chemokine Ligands 25 and 28 Play Essential Roles in Intestinal Extravasation of IgA Antibody-Secreting Cells J. Immunol., September 15, 2004; 173(6): 3668 - 3675. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Kawada, M. Sonoshita, H. Sakashita, A. Takabayashi, Y. Yamaoka, T. Manabe, K. Inaba, N. Minato, M. Oshima, and M. M. Taketo Pivotal Role of CXCR3 in Melanoma Cell Metastasis to Lymph Nodes Cancer Res., June 1, 2004; 64(11): 4010 - 4017. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Schaerli, L. Ebert, K. Willimann, A. Blaser, R. S. Roos, P. Loetscher, and B. Moser A Skin-selective Homing Mechanism for Human Immune Surveillance T Cells J. Exp. Med., May 3, 2004; 199(9): 1265 - 1275. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Wang, L. Xi, J. L. Hunt, W. Gooding, T. L. Whiteside, Z. Chen, T. E. Godfrey, and R. L. Ferris Expression Pattern of Chemokine Receptor 6 (CCR6) and CCR7 in Squamous Cell Carcinoma of the Head and Neck Identifies a Novel Metastatic Phenotype Cancer Res., March 1, 2004; 64(5): 1861 - 1866. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Hanamoto, T. Nakayama, H. Miyazato, S. Takegawa, K. Hieshima, Y. Tatsumi, A. Kanamaru, and O. Yoshie Expression of CCL28 by Reed-Sternberg Cells Defines a Major Subtype of Classical Hodgkin's Disease with Frequent Infiltration of Eosinophils and/or Plasma Cells Am. J. Pathol., March 1, 2004; 164(3): 997 - 1006. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Murakami, A. R. Cardones, S. E. Finkelstein, N. P. Restifo, B. A. Klaunberg, F. O. Nestle, S. S. Castillo, P. A. Dennis, and S. T. Hwang Immune Evasion by Murine Melanoma Mediated through CC Chemokine Receptor-10 J. Exp. Med., November 3, 2003; 198(9): 1337 - 1347. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Nagashima, D. G. Silva, N. Petrovsky, L. A. Socha, H. Suzuki, R. Saito, T. Kasukawa, I. V. Kurochkin, A. Konagaya, and C. Schonbach Inferring Higher Functional Information for RIKEN Mouse Full-Length cDNA Clones With FACTS Genome Res., June 1, 2003; 13(6): 1520 - 1533. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Soler, T. L. Humphreys, S. M. Spinola, and J. J. Campbell CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking Blood, March 1, 2003; 101(5): 1677 - 1682. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Hieshima, H. Ohtani, M. Shibano, D. Izawa, T. Nakayama, Y. Kawasaki, F. Shiba, M. Shiota, F. Katou, T. Saito, et al. CCL28 Has Dual Roles in Mucosal Immunity as a Chemokine with Broad-Spectrum Antimicrobial Activity J. Immunol., February 1, 2003; 170(3): 1452 - 1461. [Abstract] [Full Text] [PDF] |
||||
![]() |
M P Ainslie, C A McNulty, T Huynh, F A Symon, and A J Wardlaw Characterisation of adhesion receptors mediating lymphocyte adhesion to bronchial endothelium provides evidence for a distinct lung homing pathway Thorax, December 1, 2002; 57(12): 1054 - 1059. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Hudak, M. Hagen, Y. Liu, D. Catron, E. Oldham, L. M. McEvoy, and E. P. Bowman Immune Surveillance and Effector Functions of CCR10+ Skin Homing T Cells J. Immunol., August 1, 2002; 169(3): 1189 - 1196. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Gortz, R. J. B. Nibbs, P. McLean, D. Jarmin, W. Lambie, J. W. Baird, and G. J. Graham The Chemokine ESkine/CCL27 Displays Novel Modes of Intracrine and Paracrine Function J. Immunol., August 1, 2002; 169(3): 1387 - 1394. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. S. Olson and K. Ley Chemokines and chemokine receptors in leukocyte trafficking Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R7 - R28. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. B. Huber, H. C. Reinhardt, M. Exner, J. A. Burger, D. Kerjaschki, M. A. Saleem, and H. Pavenstadt Expression of Functional CCR and CXCR Chemokine Receptors in Podocytes J. Immunol., June 15, 2002; 168(12): 6244 - 6252. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. M. Murphy International Union of Pharmacology. XXX. Update on Chemokine Receptor Nomenclature Pharmacol. Rev., June 1, 2002; 54(2): 227 - 229. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Nakayama, R. Fujisawa, D. Izawa, K. Hieshima, K. Takada, and O. Yoshie Human B Cells Immortalized with Epstein-Barr Virus Upregulate CCR6 and CCR10 and Downregulate CXCR4 and CXCR5 J. Virol., February 22, 2002; 76(6): 3072 - 3077. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. E. Wiley, E. B. Gonzalez, W. Maki, M.-t. Wu, and S. T. Hwang Expression of CC Chemokine Receptor-7 and Regional Lymph Node Metastasis of B16 Murine Melanoma J Natl Cancer Inst, November 7, 2001; 93(21): 1638 - 1643. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. J. Campbell, C. E. Brightling, F. A. Symon, S. Qin, K. E. Murphy, M. Hodge, D. P. Andrew, L. Wu, E. C. Butcher, and A. J. Wardlaw Expression of Chemokine Receptors by Lung T Cells from Normal and Asthmatic Subjects J. Immunol., February 15, 2001; 166(4): 2842 - 2848. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Pan, E. J. Kunkel, U. Gosslar, N. Lazarus, P. Langdon, K. Broadwell, M. A. Vierra, M. C. Genovese, E. C. Butcher, and D. Soler Cutting Edge: A Novel Chemokine Ligand for CCR10 And CCR3 Expressed by Epithelial Cells in Mucosal Tissues J. Immunol., September 15, 2000; 165(6): 2943 - 2949. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Wang, H. Soto, E. R. Oldham, M. E. Buchanan, B. Homey, D. Catron, N. Jenkins, N. G. Copeland, D. J. Gilbert, N. Nguyen, et al. Identification of a Novel Chemokine (CCL28), which Binds CCR10 (GPR2) J. Biol. Chem., July 14, 2000; 275(29): 22313 - 22323. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |