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CUTTING EDGE |
*
S. Maugeri Foundation, Instituto di Ricovero e Cura a Carottere Scientifico (IRCCS) Pavia, Italy;
Department of Pediatric Sciences, University of Pavia, IRCCS Policlinico San Matteo, Pavia, Italy;
Basel Institute for Immunology, Basel, Switzerland; and
§
Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
The recombinase-activating genes, RAG-1 and RAG-2, can be expressed by a subset of B cells within germinal centers, where they mediate secondary V(D)J rearrangements. This receptor revision mechanism could serve either receptor diversification or tolerance-induced functions. Alternatively, it might rescue those cells the receptors of which have been damaged by somatic mutation. Less is known about the occurrence of similar mechanisms in T cells. Here we show that mature T cells with defective TCR surface expression can express RAG genes and are capable of initiating secondary V(D)J rearrangements. The possibility that a cell rescue mechanism based on the generation of a novel Ag receptor might be active in peripheral T cells is envisaged.
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