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B in the Antrum of the Human Stomach
Departments of
*
Experimental Internal Medicine,
Pathology, and
Gastroenterology, Academic Medical Center, Amsterdam, The Netherlands
Both in vitro studies and experiments in mice suggest a key role
for transcription factor NF-
B as a mediator of mucosal inflammation.
Experiments in vitro show that NF-B activation may be a critical
event in the production of proinflammatory molecules in
Helicobacter pylori-associated gastritis. This study
examines the expression and activity of NF-B in situ in antral
biopsies of 69 consecutive patients with immunohistochemical
techniques. In the uninflamed stomach, NF-B was highly expressed and
active in a subset of epithelial cells, which were identified as
predominantly G cells. In accordance with this activity, G cells were
shown to express high levels of the NF-B target cytokine TNF-
, a
well-documented stimulator of gastrin production. In patients with
H. pylori-associated gastritis, NF-B activity was
markedly enhanced. Activation occurred preferentially in the epithelial
cells. The number of cells showing activated NF-B correlated with
the activity of gastritis, a measure of neutrophil influx, whereas no
correlation was found with the chronicity of inflammation, a measure of
the presence of mononuclear inflammatory cells. This correlation is
direct evidence of the importance of NF-B-dependent signal
transduction for neutrophil influx in H.
pylori-associated gastritis.
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