The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kim, M. G.
Right arrow Articles by Schwartz, R. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kim, M. G.
Right arrow Articles by Schwartz, R. H.
The Journal of Immunology, 2000, 164: 3185-3192.
Copyright © 2000 by The American Association of Immunologists

A Putative 12 Transmembrane Domain Cotransporter Expressed in Thymic Cortical Epithelial Cells

Moon Gyo Kim1, Francis A. Flomerfelt, Kee-Nyung Lee2, Chuan Chen and Ronald H. Schwartz3

Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda MD 20892

We have isolated a full-length cDNA clone (thymic stromal origin (TSO)-1C12) from a SCID thymus library using a probe from a PCR-based subtractive library enriched for sequences from fetal thymic stromal cells. TSO-1C12 mRNA is expressed mainly in the thymic cortex and is highly enriched in SCID thymus. Expression per cell is highest during fetal thymus development and decreases after day 16. Antipeptide Abs immunoprecipitated a hydrophobic, plasma membrane glycoprotein (thymic stromal cotransporter, TSCOT) whose translated sequence has weak homology to bacterial antiporters and mammalian cation cotransporters with 12 transmembrane domains. TSCOT represents a new member of this superfamily that is highly expressed in thymic cortical epithelial cells.




This article has been cited by other articles:


Home page
 Hum Mol GenetHome page
M. T. Engelmark, E. L. Ivansson, J. J. Magnusson, I. M. Gustavsson, A. H. Beskow, P. K.E. Magnusson, and U. B. Gyllensten
Identification of susceptibility loci for cervical carcinoma by genome scan of affected sib-pairs
Hum. Mol. Genet., November 15, 2006; 15(22): 3351 - 3360.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
D. Puthier, F. Joly, M. Irla, M. Saade, G. Victorero, B. Loriod, and C. Nguyen
A General Survey of Thymocyte Differentiation by Transcriptional Analysis of Knockout Mouse Models
J. Immunol., November 15, 2004; 173(10): 6109 - 6118.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
H. Obermann, A. Wingbermuhle, S. Munz, and C. Kirchhoff
A Putative 12-Transmembrane Domain Cotransporter Associated With Apical Membranes of the Epididymal Duct
J Androl, July 1, 2003; 24(4): 542 - 556.
[Abstract] [Full Text] [PDF]

Home page
 Mol Hum ReprodHome page
C. Kirchhoff
The dog as a model to study human epididymal function at a molecular level
Mol. Hum. Reprod., August 1, 2002; 8(8): 695 - 701.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.