The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     
 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frauwirth, K. A.
Right arrow Articles by Thompson, C. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frauwirth, K. A.
Right arrow Articles by Thompson, C. B.
The Journal of Immunology, 2000, 164: 2987-2993.
Copyright © 2000 by The American Association of Immunologists

Induction of T Cell Anergy in the Absence of CTLA-4/B7 Interaction1

Kenneth A. Frauwirth*, Maria-Luisa Alegre{dagger} and Craig B. Thompson2,*

* Abramson Family Cancer Research Institute and Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA 19104; and {dagger} Department of Medicine, University of Chicago, Chicago, IL 60637

Immunologic tolerance in T lymphocytes is maintained through both thymic and peripheral contributions. One peripheral tolerance mechanism is the induction of T cell anergy, a form of nonresponsiveness resulting from incomplete T cell activation, such as stimulation through the TCR in the absence of costimulation. Recent reports have suggested that engagement of the inhibitory receptor CTLA-4 by its B7 ligand is critical for the initiation of anergy. We tested the importance of CTLA-4 in anergy induction in primary T cells with an in vitro anergy system. Using both CTLA-4/B7-blocking agents and CTLA-4-deficient T cells, we found that T cell anergy can be established in the absence of CTLA-4 expression and/or function. Even in the absence of CTLA-4 signal transduction, T cells activated solely through TCR ligation lose the ability to proliferate as a result of autocrine IL-2 production upon subsequent receptor engagement. Thus, CTLA-4 signaling is not required for the development of T cell anergy.




This article has been cited by other articles:


Home page
J. Immunol.Home page
S. Chikuma, S. Terawaki, T. Hayashi, R. Nabeshima, T. Yoshida, S. Shibayama, T. Okazaki, and T. Honjo
PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo
J. Immunol., June 1, 2009; 182(11): 6682 - 6689.
[Abstract] [Full Text] [PDF]


Home page
Exp. Biol. Med.Home page
K. Kolegraff, P. Bostik, and A. A. Ansari
Characterization and role of lentivirus-associated host proteins.
Experimental Biology and Medicine, March 1, 2006; 231(3): 252 - 263.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
P. R. O. Salvalaggio, G. Camirand, C. E. Ariyan, S. Deng, L. Rogozinski, G. P. Basadonna, and D. M. Rothstein
Antigen Exposure during Enhanced CTLA-4 Expression Promotes Allograft Tolerance In Vivo
J. Immunol., February 15, 2006; 176(4): 2292 - 2298.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
S. Mukherjee, A. Ahmed, and D. Nandi
CTLA4-CD80/CD86 interactions on primary mouse CD4+ T cells integrate signal-strength information to modulate activation with Concanavalin A
J. Leukoc. Biol., July 1, 2005; 78(1): 144 - 157.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
M. Inobe and R. H. Schwartz
CTLA-4 Engagement Acts as a Brake on CD4+ T Cell Proliferation and Cytokine Production but Is Not Required for Tuning T Cell Reactivity in Adaptive Tolerance
J. Immunol., December 15, 2004; 173(12): 7239 - 7248.
[Abstract] [Full Text] [PDF]


Home page
Clin. Microbiol. Rev.Home page
G. Borkow and Z. Bentwich
Chronic Immune Activation Associated with Chronic Helminthic and Human Immunodeficiency Virus Infections: Role of Hyporesponsiveness and Anergy
Clin. Microbiol. Rev., October 1, 2004; 17(4): 1012 - 1030.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
F. Andris, S. Denanglaire, F. de Mattia, J. Urbain, and O. Leo
Naive T Cells Are Resistant to Anergy Induction by Anti-CD3 Antibodies
J. Immunol., September 1, 2004; 173(5): 3201 - 3208.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
T. N. Eagar, D. M. Turley, J. Padilla, N. J. Karandikar, L. Tan, J. A. Bluestone, and S. D. Miller
CTLA-4 Regulates Expansion and Differentiation of Th1 Cells Following Induction of Peripheral T Cell Tolerance
J. Immunol., June 15, 2004; 172(12): 7442 - 7450.
[Abstract] [Full Text] [PDF]


Home page
J. Leukoc. Biol.Home page
S. Mukherjee, P. K. Maiti, and D. Nandi
Role of CD80, CD86, and CTLA4 on mouse CD4+ T lymphocytes in enhancing cell-cycle progression and survival after activation with PMA and ionomycin
J. Leukoc. Biol., November 1, 2002; 72(5): 921 - 931.
[Abstract] [Full Text] [PDF]


Home page
J. Biol. Chem.Home page
Y. L. Wang, K. A. Frauwirth, S. M. Rangwala, M. A. Lazar, and C. B. Thompson
Thiazolidinedione Activation of Peroxisome Proliferator-activated Receptor gamma Can Enhance Mitochondrial Potential and Promote Cell Survival
J. Biol. Chem., August 23, 2002; 277(35): 31781 - 31788.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
R. E. Miller, J. Jones, T. Le, J. Whitmore, N. Boiani, B. Gliniak, and D. H. Lynch
4-1BB-Specific Monoclonal Antibody Promotes the Generation of Tumor-Specific Immune Responses by Direct Activation of CD8 T Cells in a CD40-Dependent Manner
J. Immunol., August 15, 2002; 169(4): 1792 - 1800.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
E. A. Tivol and J. Gorski
Re-establishing Peripheral Tolerance in the Absence of CTLA-4: Complementation by Wild-Type T Cells Points to an Indirect Role for CTLA-4
J. Immunol., August 15, 2002; 169(4): 1852 - 1858.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
T. L. Vanasek, A. Khoruts, T. Zell, and D. L. Mueller
Antagonistic Roles for CTLA-4 and the Mammalian Target of Rapamycin in the Regulation of Clonal Anergy: Enhanced Cell Cycle Progression Promotes Recall Antigen Responsiveness
J. Immunol., November 15, 2001; 167(10): 5636 - 5644.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
K. A. Frauwirth, M.-L. Alegre, and C. B. Thompson
CTLA-4 Is Not Required for Induction of CD8+ T Cell Anergy In Vivo
J. Immunol., November 1, 2001; 167(9): 4936 - 4941.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
J. Ermann, V. Szanya, G. S. Ford, V. Paragas, C. G. Fathman, and K. Lejon
CD4+CD25+ T Cells Facilitate the Induction of T Cell Anergy
J. Immunol., October 15, 2001; 167(8): 4271 - 4275.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
M.-N. Avice, M. Rubio, M. Sergerie, G. Delespesse, and M. Sarfati
Role of CD47 in the Induction of Human Naive T Cell Anergy
J. Immunol., September 1, 2001; 167(5): 2459 - 2468.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
E. Prager, G. Staffler, O. Majdic, M. D. Saemann, S. Godar, G. J. Zlabinger, and H. Stockinger
Induction of Hyporesponsiveness and Impaired T Lymphocyte Activation by the CD31 Receptor:Ligand Pathway in T Cells
J. Immunol., February 15, 2001; 166(4): 2364 - 2371.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
J.-G. Chai, S. Vendetti, E. Amofah, J. Dyson, and R. Lechler
CD152 Ligation by CD80 on T Cells Is Required for the Induction of Unresponsiveness by Costimulation-Deficient Antigen Presentation
J. Immunol., September 15, 2000; 165(6): 3037 - 3042.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.