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The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
The dendritic cells (DC) of mouse spleen and thymus were examined
for expression of CD4 and CD8. Provided care was taken to avoid
selective extraction or selective depletion of DC subpopulations, three
main types of DC were detected in mouse spleen: a major new population
of CD4+8- DEC-205low
CD11bhigh DC, together with the previously described
CD4-8- DEC-205low
CD11bhigh DC and CD4-8
+
DEC-205high CD11blow DC. The CD4 on the surface
of the CD4+ splenic DC subpopulation was produced by the DC
themselves, and CD4 RNA transcripts were present. Likewise, the CD8
on the surface of the splenic CD8+ DC was shown to be a
product of the DC themselves, in agreement with earlier evidence. All
three spleen DC types would be considered as mature, based on
expression of CD80, CD86, and CD40 as well as on T cell stimulating
function. Mouse thymuses appeared to contain two DC types; both were
DEC-205highCD11blow, but they differed in the
level of CD8 expression. However, as well as this authenticated
marker expression, immunofluorescent staining was also found to reflect
a series of artifacts, due to the autofluorescence of contaminating
cells and due to pickup of CD4 and CD8ß. By constructing mice
chimeric for the hemopoietic lineages using mixtures of wild-type bone
marrow with CD4null or CD8null bone marrow,
a marked pickup by thymic DC of Ags derived from thymocytes was
demonstrated.
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K. P. A. MacDonald, V. Rowe, H. M. Bofinger, R. Thomas, T. Sasmono, D. A. Hume, and G. R. Hill The Colony-Stimulating Factor 1 Receptor Is Expressed on Dendritic Cells during Differentiation and Regulates Their Expansion J. Immunol., August 1, 2005; 175(3): 1399 - 1405. [Abstract] [Full Text] [PDF]
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G. T. Belz, K. Shortman, M. J. Bevan, and W. R. Heath CD8{alpha}+ Dendritic Cells Selectively Present MHC Class I-Restricted Noncytolytic Viral and Intracellular Bacterial Antigens In Vivo J. Immunol., July 1, 2005; 175(1): 196 - 200. [Abstract] [Full Text] [PDF]
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Y. Chung, J.-H. Chang, M.-N. Kweon, P. D. Rennert, and C.-Y. Kang CD8{alpha}-11b+ dendritic cells but not CD8{alpha}+ dendritic cells mediate cross-tolerance toward intestinal antigens Blood, July 1, 2005; 106(1): 201 - 206. [Abstract] [Full Text] [PDF]
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S. H. Naik, A. I. Proietto, N. S. Wilson, A. Dakic, P. Schnorrer, M. Fuchsberger, M. H. Lahoud, M. O'Keeffe, Q.-x. Shao, W.-f. Chen, et al. Cutting Edge: Generation of Splenic CD8+ and CD8- Dendritic Cell Equivalents in Fms-Like Tyrosine Kinase 3 Ligand Bone Marrow Cultures J. Immunol., June 1, 2005; 174(11): 6592 - 6597. [Abstract] [Full Text] [PDF]
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M. O'Keeffe, T. C. Brodnicki, B. Fancke, D. Vremec, G. Morahan, E. Maraskovsky, R. Steptoe, L. C. Harrison, and K. Shortman Fms-like tyrosine kinase 3 ligand administration overcomes a genetically determined dendritic cell deficiency in NOD mice and protects against diabetes development Int. Immunol., March 1, 2005; 17(3): 307 - 314. [Abstract] [Full Text] [PDF]
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T. Hieronymus, T. C. Gust, R. D. Kirsch, T. Jorgas, G. Blendinger, M. Goncharenko, K. Supplitt, S. Rose-John, A. M. Muller, and M. Zenke Progressive and Controlled Development of Mouse Dendritic Cells from Flt3+CD11b+ Progenitors In Vitro J. Immunol., March 1, 2005; 174(5): 2552 - 2562. [Abstract] [Full Text] [PDF]
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K. P. A. MacDonald, V. Rowe, A. D. Clouston, J. K. Welply, R. D. Kuns, J. L. M. Ferrara, R. Thomas, and G. R. Hill Cytokine Expanded Myeloid Precursors Function as Regulatory Antigen-Presenting Cells and Promote Tolerance through IL-10-Producing Regulatory T Cells J. Immunol., February 15, 2005; 174(4): 1841 - 1850. [Abstract] [Full Text] [PDF]
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M. Montoya, M. J. Edwards, D. M. Reid, and P. Borrow Rapid Activation of Spleen Dendritic Cell Subsets following Lymphocytic Choriomeningitis Virus Infection of Mice: Analysis of the Involvement of Type 1 IFN J. Immunol., February 15, 2005; 174(4): 1851 - 1861. [Abstract] [Full Text] [PDF]
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N. Feik, I. Bilic, J. Tinhofer, B. Unger, D. R. Littman, and W. Ellmeier Functional and Molecular Analysis of the Double-Positive Stage-Specific CD8 Enhancer E8III during Thymocyte Development J. Immunol., February 1, 2005; 174(3): 1513 - 1524. [Abstract] [Full Text] [PDF]
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S. L. Nutt, D. Metcalf, A. D'Amico, M. Polli, and L. Wu Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors J. Exp. Med., January 18, 2005; 201(2): 221 - 231. [Abstract] [Full Text] [PDF]
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T. B. Oriss, M. Ostroukhova, C. Seguin-Devaux, B. Dixon-McCarthy, D. B. Stolz, S. C. Watkins, B. Pillemer, P. Ray, and A. Ray Dynamics of Dendritic Cell Phenotype and Interactions with CD4+ T Cells in Airway Inflammation and Tolerance J. Immunol., January 15, 2005; 174(2): 854 - 863. [Abstract] [Full Text] [PDF]
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 A. Kissenpfennig, S. Ait-Yahia, V. Clair-Moninot, H. Stossel, E. Badell, Y. Bordat, J. L. Pooley, T. Lang, E. Prina, I. Coste, et al. Disruption of the langerin/CD207 Gene Abolishes Birbeck Granules without a Marked Loss of Langerhans Cell Function Mol. Cell. Biol., January 1, 2005; 25(1): 88 - 99. [Abstract] [Full Text] [PDF]
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G. A. Corbin and J. T. Harty Duration of Infection and Antigen Display Have Minimal Influence on the Kinetics of the CD4+ T Cell Response to Listeria monocytogenes Infection J. Immunol., November 1, 2004; 173(9): 5679 - 5687. [Abstract] [Full Text] [PDF]
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G. L. Stephens, R. S. McHugh, M. J. Whitters, D. A. Young, D. Luxenberg, B. M. Carreno, M. Collins, and E. M. Shevach Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells J. Immunol., October 15, 2004; 173(8): 5008 - 5020. [Abstract] [Full Text] [PDF]
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F. Palamara, S. Meindl, M. Holcmann, P. Luhrs, G. Stingl, and M. Sibilia Identification and Characterization of pDC-Like Cells in Normal Mouse Skin and Melanomas Treated with Imiquimod J. Immunol., September 1, 2004; 173(5): 3051 - 3061. [Abstract] [Full Text] [PDF]
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K. E. Lawlor, I. K. Campbell, D. Metcalf, K. O'Donnell, A. van Nieuwenhuijze, A. W. Roberts, and I. P. Wicks Critical role for granulocyte colony-stimulating factor in inflammatory arthritis PNAS, August 3, 2004; 101(31): 11398 - 11403. [Abstract] [Full Text] [PDF]
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S. Suzuki, K. Honma, T. Matsuyama, K. Suzuki, K. Toriyama, I. Akitoyo, K. Yamamoto, T. Suematsu, M. Nakamura, K. Yui, et al. From the Cover: Critical roles of interferon regulatory factor 4 in CD11bhighCD8{alpha}- dendritic cell development PNAS, June 15, 2004; 101(24): 8981 - 8986. [Abstract] [Full Text] [PDF]
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G. T. Belz, C. M. Smith, L. Kleinert, P. Reading, A. Brooks, K. Shortman, F. R. Carbone, and W. R. Heath Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus PNAS, June 8, 2004; 101(23): 8670 - 8675. [Abstract] [Full Text] [PDF]
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D. Homann, D. B. McGavern, and M. B. A. Oldstone Visualizing the Viral Burden: Phenotypic and Functional Alterations of T Cells and APCs during Persistent Infection J. Immunol., May 15, 2004; 172(10): 6239 - 6250. [Abstract] [Full Text] [PDF]
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M. Franchini, H. Hefti, S. Vollstedt, B. Glanzmann, M. Riesen, M. Ackermann, P. Chaplin, K. Shortman, and M. Suter Dendritic Cells from Mice Neonatally Vaccinated with Modified Vaccinia Virus Ankara Transfer Resistance against Herpes Simplex Virus Type I to Naive One-Week-Old Mice J. Immunol., May 15, 2004; 172(10): 6304 - 6312. [Abstract] [Full Text] [PDF]
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T. Baldwin, S. Henri, J. Curtis, M. O'Keeffe, D. Vremec, K. Shortman, and E. Handman Dendritic Cell Populations in Leishmania major-Infected Skin and Draining Lymph Nodes Infect. Immun., April 1, 2004; 72(4): 1991 - 2001. [Abstract] [Full Text] [PDF]
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B. Quah, K. Ni, and H. C. O'Neill In vitro hematopoiesis produces a distinct class of immature dendritic cells from spleen progenitors with limited T cell stimulation capacity Int. Immunol., April 1, 2004; 16(4): 567 - 577. [Abstract] [Full Text] [PDF]
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H.-J. Kim, T. Kammertoens, M. Janke, O. Schmetzer, Z. Qin, C. Berek, and T. Blankenstein Establishment of Early Lymphoid Organ Infrastructure in Transplanted Tumors Mediated by Local Production of Lymphotoxin {alpha} and in the Combined Absence of Functional B and T Cells J. Immunol., April 1, 2004; 172(7): 4037 - 4047. [Abstract] [Full Text] [PDF]
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E. Ichikawa, S. Hida, Y. Omatsu, S. Shimoyama, K. Takahara, S. Miyagawa, K. Inaba, and S. Taki Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2 PNAS, March 16, 2004; 101(11): 3909 - 3914. [Abstract] [Full Text] [PDF]
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N. S. Wilson, D. El-Sukkari, and J. A. Villadangos Dendritic cells constitutively present self antigens in their immature state in vivo and regulate antigen presentation by controlling the rates of MHC class II synthesis and endocytosis Blood, March 15, 2004; 103(6): 2187 - 2195. [Abstract] [Full Text] [PDF]
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A. B. van Spriel, K. L. Puls, M. Sofi, D. Pouniotis, H. Hochrein, Z. Orinska, K.-P. Knobeloch, M. Plebanski, and M. D. Wright A Regulatory Role for CD37 in T Cell Proliferation J. Immunol., March 1, 2004; 172(5): 2953 - 2961. [Abstract] [Full Text] [PDF]
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G. T. Belz, C. M. Smith, D. Eichner, K. Shortman, G. Karupiah, F. R. Carbone, and W. R. Heath Cutting Edge: Conventional CD8{alpha}+ Dendritic Cells Are Generally Involved in Priming CTL Immunity to Viruses J. Immunol., February 15, 2004; 172(4): 1996 - 2000. [Abstract] [Full Text] [PDF]
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C. Johansson and M. J. Wick Liver Dendritic Cells Present Bacterial Antigens and Produce Cytokines upon Salmonella Encounter J. Immunol., February 15, 2004; 172(4): 2496 - 2503. [Abstract] [Full Text] [PDF]
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V. Paharkova-Vatchkova, R. Maldonado, and S. Kovats Estrogen Preferentially Promotes the Differentiation of CD11c+ CD11bintermediate Dendritic Cells from Bone Marrow Precursors J. Immunol., February 1, 2004; 172(3): 1426 - 1436. [Abstract] [Full Text] [PDF]
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K. Attanavanich and J. F. Kearney Marginal Zone, but Not Follicular B Cells, Are Potent Activators of Naive CD4 T Cells J. Immunol., January 15, 2004; 172(2): 803 - 811. [Abstract] [Full Text] [PDF]
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