| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Trauma Surgery, University of Freiburg, Freiburg, Germany;
Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109;
Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH 45229;
§
Department of Physiology, University of Nebraska School of Dentistry, Lincoln, NE 68198; and
¶
Department of Surgery, University of Louisville School of Medicine, Louisville, KY 40292
The role of the CC chemokines, macrophage inflammatory protein-1ß
(MIP-1ß), monocyte chemotactic peptide-1 (MCP-1), and RANTES, in
acute lung inflammatory injury induced by intrapulmonary deposition of
IgG immune complexes injury in rats was determined. Rat MIP-1ß,
MCP-1, and RANTES were cloned, the proteins were expressed, and
neutralizing Abs were developed. mRNA and protein expression for
MIP-1ß and MCP-1 were up-regulated during the inflammatory response,
while mRNA and protein expression for RANTES were constitutive and
unchanged during the inflammatory response. Treatment of rats with
anti-MIP-1ß Ab significantly decreased vascular permeability by
37% (p = 0.012), reduced neutrophil recruitment
into lung by 65% (p = 0.047), and suppressed
levels of TNF-
in bronchoalveolar lavage fluids by 61%
(p = 0.008). Treatment of rats with anti-rat
MCP-1 or anti-rat RANTES had no effect on the development of lung
injury. In animals pretreated intratracheally with blocking Abs to
MCP-1, RANTES, or MIP-1ß, significant reductions in the
bronchoalveolar lavage content of these chemokines occurred, suggesting
that these Abs had reached their targets. Conversely, exogenously
MIP-1ß, but not RANTES or MCP-1, caused enhancement of the lung
vascular leak. These data indicate that MIP-1ß, but not MCP-1 or
RANTES, plays an important role in intrapulmonary recruitment of
neutrophils and development of lung injury in the model employed. The
findings suggest that in chemokine-dependent inflammatory responses in
lung CC chemokines do not necessarily demonstrate redundant
function.
This article has been cited by other articles:
|
|
 |
|
  J. L. Dooley, D. Abdel-Latif, C. D. St. Laurent, L. Puttagunta, D. Befus, and P. Lacy Regulation of inflammation by Rac2 in immune complex-mediated acute lung injury Am J Physiol Lung Cell Mol Physiol, December 1, 2009; 297(6): L1091 - L1102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Hartl, S. Krauss-Etschmann, B. Koller, P. L. Hordijk, T. W. Kuijpers, F. Hoffmann, A. Hector, E. Eber, V. Marcos, I. Bittmann, et al. Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung Diseases J. Immunol., December 1, 2008; 181(11): 8053 - 8067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang, S. Tasaka, Y. Shiraishi, K. Fukunaga, W. Yamada, H. Seki, Y. Ogawa, K. Miyamoto, Y. Nakano, N. Hasegawa, et al. Role of Soluble Receptor for Advanced Glycation End Products on Endotoxin-induced Lung Injury Am. J. Respir. Crit. Care Med., August 15, 2008; 178(4): 356 - 362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. McCourtie, H. E. Merry, A. S. Farivar, C. H. Goss, and M. S. Mulligan Alveolar Macrophage Secretory Products Augment the Response of Rat Pulmonary Artery Endothelial Cells to Hypoxia and Reoxygenation Ann. Thorac. Surg., March 1, 2008; 85(3): 1056 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sun, R. D. Ramnath, and M. Bhatia Neuropeptide substance P upregulates chemokine and chemokine receptor expression in primary mouse neutrophils Am J Physiol Cell Physiol, August 1, 2007; 293(2): C696 - C704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cittera, M. Leidi, C. Buracchi, F. Pasqualini, S. Sozzani, A. Vecchi, J. D. Waterfield, M. Introna, and J. Golay The CCL3 Family of Chemokines and Innate Immunity Cooperate In Vivo in the Eradication of an Established Lymphoma Xenograft by Rituximab J. Immunol., May 15, 2007; 178(10): 6616 - 6623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Wilson, J. M. Napper, J. Denvir, V. E. Sollars, and H. D. Yu Defect in early lung defence against Pseudomonas aeruginosa in DBA/2 mice is associated with acute inflammatory lung injury and reduced bactericidal activity in naive macrophages Microbiology, April 1, 2007; 153(4): 968 - 979. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Puneet, A. Hegde, S. W. Ng, H. Y. Lau, J. Lu, S. M. Moochhala, and M. Bhatia Preprotachykinin-A Gene Products Are Key Mediators of Lung Injury in Polymicrobial Sepsis J. Immunol., March 15, 2006; 176(6): 3813 - 3820. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Neff, B. R. Z'graggen, T. A. Neff, M. Jamnicki-Abegg, D. Suter, R. C. Schimmer, C. Booy, H. Joch, T. Pasch, P. A. Ward, et al. Inflammatory response of tracheobronchial epithelial cells to endotoxin Am J Physiol Lung Cell Mol Physiol, January 1, 2006; 290(1): L86 - L96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. S. Ko and C.-H. Cho The Diverse Actions of Nicotine and Different Extracted Fractions from Tobacco Smoke against Hapten-Induced Colitis in Rats Toxicol. Sci., September 1, 2005; 87(1): 285 - 295. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Capelli, A. Di Stefano, I. Gnemmi, and C. F. Donner CCR5 expression and CC chemokine levels in idiopathic pulmonary fibrosis Eur. Respir. J., April 1, 2005; 25(4): 701 - 707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Speyer, N. J. Rancilio, S. D. McClintock, J. D. Crawford, H. Gao, J. V. Sarma, and P. A. Ward Regulatory effects of estrogen on acute lung inflammation in mice Am J Physiol Cell Physiol, April 1, 2005; 288(4): C881 - C890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Speyer, H. Gao, N. J. Rancilio, T. A. Neff, G. B. Huffnagle, J. V. Sarma, and P. A. Ward Novel Chemokine Responsiveness and Mobilization of Neutrophils during Sepsis Am. J. Pathol., December 1, 2004; 165(6): 2187 - 2196. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Inoshima, K. Kuwano, N. Hamada, N. Hagimoto, M. Yoshimi, T. Maeyama, A. Takeshita, S. Kitamoto, K. Egashira, and N. Hara Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L1038 - L1044. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Krishnadasan, A. S. Farivar, B. V. Naidu, S. M. Woolley, K. Byrne, C. H. Fraga, and M. S. Mulligan {beta}-chemokine function in experimental lung ischemia-reperfusion injury Ann. Thorac. Surg., March 1, 2004; 77(3): 1056 - 1062. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Vozzelli, S. N. Mason, M. H. Whorton, and R. L. Auten Jr. Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung Am J Physiol Lung Cell Mol Physiol, March 1, 2004; 286(3): L488 - L493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Panoskaltsis-Mortari, J. R. Hermanson, E. Taras, O. D. Wangensteen, I. F. Charo, B. J. Rollins, and B. R. Blazar Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L284 - L292. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Speyer, T. A. Neff, R. L. Warner, R.-F. Guo, J. V. Sarma, N. C. Riedemann, M. E. Murphy, H. S. Murphy, and P. A. Ward Regulatory Effects of iNOS on Acute Lung Inflammatory Responses in Mice Am. J. Pathol., December 1, 2003; 163(6): 2319 - 2328. [Abstract] [Full Text]
|
|
|
|
 |
|
 A. Fukushima, A. Ozaki, K. Fukata, W. Ishida, and H. Ueno Ag-Specific Recognition, Activation, and Effector Function of T Cells in the Conjunctiva with Experimental Immune-Mediated Blepharoconjunctivitis Invest. Ophthalmol. Vis. Sci., October 1, 2003; 44(10): 4366 - 4374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Panoskaltsis-Mortari, J. R. Hermanson, E. Taras, O. D. Wangensteen, J. S. Serody, and B. R. Blazar Acceleration of idiopathic pneumonia syndrome (IPS) in the absence of donor MIP-1alpha (CCL3) after allogeneic BMT in mice Blood, May 1, 2003; 101(9): 3714 - 3721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Madjdpour, U. R. Jewell, S. Kneller, U. Ziegler, R. Schwendener, C. Booy, L. Klausli, T. Pasch, R. C. Schimmer, and B. Beck-Schimmer Decreased alveolar oxygen induces lung inflammation Am J Physiol Lung Cell Mol Physiol, February 1, 2003; 284(2): L360 - L367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Moran, D. A. Arenberg, C.-C. Huang, T. J. Giordano, D. G. Thomas, D. E. Misek, G. Chen, M. D. Iannettoni, M. B. Orringer, S. Hanash, et al. RANTES Expression Is a Predictor of Survival in Stage I Lung Adenocarcinoma Clin. Cancer Res., December 1, 2002; 8(12): 3803 - 3812. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Fernandez, M. Renedo, C. Garcia-Rodriguez, and M. Sanchez Crespo Activation of Monocytic Cells Through Fc{gamma} Receptors Induces the Expression of Macrophage-Inflammatory Protein (MIP)-1{alpha}, MIP-1{beta}, and RANTES J. Immunol., September 15, 2002; 169(6): 3321 - 3328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Luhrmann, U. Deiters, J. Skokowa, M. Hanke, J. E. Gessner, P. F. Muhlradt, R. Pabst, and T. Tschernig In Vivo Effects of a Synthetic 2-Kilodalton Macrophage-Activating Lipopeptide of Mycoplasma fermentans after Pulmonary Application Infect. Immun., July 1, 2002; 70(7): 3785 - 3792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. CAPELLI, A. DI STEFANO, M. LUSUARDI, I. GNEMMI, and C. F. DONNER Increased Macrophage Inflammatory Protein-1alpha and Macrophage Inflammatory Protein-1beta Levels in Bronchoalveolar Lavage Fluid of Patients Affected by Different Stages of Pulmonary Sarcoidosis Am. J. Respir. Crit. Care Med., January 15, 2002; 165(2): 236 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Michalec, B. K. Choudhury, E. Postlethwait, J. S. Wild, R. Alam, M. Lett-Brown, and S. Sur CCL7 and CXCL10 Orchestrate Oxidative Stress-Induced Neutrophilic Lung Inflammation J. Immunol., January 15, 2002; 168(2): 846 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Jordan, R.-F. Guo, E. C. Yun, V. Sarma, R. L. Warner, L. D. Crouch, G. Senaldi, T. R. Ulich, and P. A. Ward Role of IL-18 in Acute Lung Inflammation J. Immunol., December 15, 2001; 167(12): 7060 - 7068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Fillion, N. Ouellet, M. Simard, Y. Bergeron, S. Sato, and M. G. Bergeron Role of Chemokines and Formyl Peptides in Pneumococcal Pneumonia-Induced Monocyte/Macrophage Recruitment J. Immunol., June 15, 2001; 166(12): 7353 - 7361. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.-F. Guo, A. B. Lentsch, R. L. Warner, M. Huber-Lang, J. V. Sarma, T. Hlaing, M. M. Shi, N. W. Lukacs, and P. A. Ward Regulatory Effects of Eotaxin on Acute Lung Inflammatory Injury J. Immunol., April 15, 2001; 166(8): 5208 - 5218. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Maus, S. Herold, H. Muth, R. Maus, L. Ermert, M. Ermert, N. Weissmann, S. Rosseau, W. Seeger, F. Grimminger, et al. Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD14 Am J Physiol Lung Cell Mol Physiol, January 1, 2001; 280(1): L58 - L68. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
