| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Department of Bioregulation, Biomedical Research Center, Osaka University Graduate School of Medicine, Osaka, Japan;
First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan;
Departments of Biochemistry and Internal Medicine, School of Medicine, Keio University, Tokyo, Japan;
§
Second Department of Internal Medicine, National Defense Medical College, Saitama, Japan; and
¶
Department of Pathology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is essential
for lymphocyte trafficking to gut-associated lymphoid tissues and is
implicated in inflammatory disorders in the gut and pancreatic islets.
In this study, we examined the functional role of MAdCAM-1 during rat
ontogeny using newly generated specific mAb. As previously observed in
mice and humans, MAdCAM-1 was preferentially expressed in high
endothelial venules (HEV) in gut-associated lymphoid tissues and
venules of lamina propria in adult rats. Lymphocyte rolling and
adhesion on HEV in Peyer’s patches (PP) were completely abrogated with
neutralizing anti-MAdCAM-1 mAb, in agreement with the notion that
MAdCAM-1 is the principal HEV ligand for lymphocyte rolling and
adhesion in adult PP. In the developing gastrointestinal tract,
MAdCAM-1 was widely expressed in the venules of the lamina propria of
fetal rats. In addition, MAdCAM-1 was also expressed in follicular
dendritic cells in the neonatal PP. Interestingly, MAdCAM-1 expression
was found also in nonmucosal tissues during ontogeny. MAdCAM-1 was
transiently expressed in blood vascular endothelial cells in the fetal
skin and neonatal thymus. Notably, MAdCAM-1-positive blood vessels were
localized mainly in the cortico-medullary junction in the neonatal
thymus and about 10–20% of thymocytes, most of which were either CD4,
CD8 double positive or single positive specifically reacted with
soluble MAdCAM-1 via integrin 
4ß7. After
birth, MAdCAM-1 expression in thymus blood vessels disappeared and
concomitantly, the soluble MAdCAM-1-reactive thymocytes were rapidly
down-regulated. Our results suggest that MAdCAM-1 functions as a
vascular addressin in not only mucosal, but also nonmucosal lymphoid
tissues during ontogeny.
This article has been cited by other articles:
|
|
 |
|
  E. T. Cadman, A. Y. Abdallah, C. Voisine, A.-M. Sponaas, P. Corran, T. Lamb, D. Brown, F. Ndungu, and J. Langhorne Alterations of Splenic Architecture in Malaria Are Induced Independently of Toll-Like Receptors 2, 4, and 9 or MyD88 and May Affect Antibody Affinity Infect. Immun., September 1, 2008; 76(9): 3924 - 3931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ahrendt, S. I. Hammerschmidt, O. Pabst, R. Pabst, and U. Bode Stromal Cells Confer Lymph Node-Specific Properties by Shaping a Unique Microenvironment Influencing Local Immune Responses J. Immunol., August 1, 2008; 181(3): 1898 - 1907. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Umemoto, T. Tanaka, H. Kanda, S. Jin, K. Tohya, K. Otani, T. Matsutani, M. Matsumoto, Y. Ebisuno, M. H. Jang, et al. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow J. Exp. Med., June 12, 2006; 203(6): 1603 - 1614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Okada, Y Tsuzuki, J Miyazaki, K Matsuzaki, R Hokari, S Komoto, S Kato, A Kawaguchi, S Nagao, K Itoh, et al. Propionibacterium freudenreichii component 1.4-dihydroxy-2-naphthoic acid (DHNA) attenuates dextran sodium sulphate induced colitis by modulation of bacterial flora and lymphocyte homing Gut, May 1, 2006; 55(5): 681 - 688. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kanemitsu, Y. Ebisuno, T. Tanaka, K. Otani, H. Hayasaka, T. Kaisho, S. Akira, K. Katagiri, T. Kinashi, N. Fujita, et al. CXCL13 is an arrest chemokine for B cells in high endothelial venules Blood, October 15, 2005; 106(8): 2613 - 2618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Mintern, M. M. Maurice, H. L. Ploegh, and E. Schott Thymic Selection and Peripheral Activation of CD8 T Cells by the Same Class I MHC/Peptide Complex J. Immunol., January 1, 2004; 172(1): 699 - 708. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Donskoy, D. Foss, and I. Goldschneider Gated Importation of Prothymocytes by Adult Mouse Thymus Is Coordinated with Their Periodic Mobilization from Bone Marrow J. Immunol., October 1, 2003; 171(7): 3568 - 3575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Louis, G. Dulude, S. Corneau, S. Brochu, C. Boileau, C. Meunier, C. Cote, N. Labrecque, and C. Perreault Changes in the lymph node microenvironment induced by oncostatin M Blood, August 15, 2003; 102(4): 1397 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Lo, T. T. Lu, and J. G. Cyster Integrin-dependence of Lymphocyte Entry into the Splenic White Pulp J. Exp. Med., February 3, 2003; 197(3): 353 - 361. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Usui, T. Murai, T. Tanaka, K. Yamaguchi, D. Nagakubo, C. M. Lee, M. Kiyomi, S. Tamura, Y. Matsuzawa, and M. Miyasaka Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells Int. Immunol., November 1, 2002; 14(11): 1273 - 1282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hashi, H. Yoshida, K. Honda, S. Fraser, H. Kubo, M. Awane, A. Takabayashi, H. Nakano, Y. Yamaoka, and S.-I. Nishikawa Compartmentalization of Peyer's Patch Anlagen Before Lymphocyte Entry J. Immunol., March 15, 2001; 166(6): 3702 - 3709. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Hirose, H. Kawashima, O. Yoshie, K. Tashiro, and M. Miyasaka Versican Interacts with Chemokines and Modulates Cellular Responses J. Biol. Chem., February 9, 2001; 276(7): 5228 - 5234. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
