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Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853 The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this factor.
The eggs of Schistosoma mansoni are strong inducers
of a Th2 response, and previous work has shown that Ag-specific IL-6 is
produced within 24 h after the injection of eggs into mice.
Investigations to determine the role of IL-6 in orchestrating the early
response to schistosome eggs have revealed that IL-12 is rapidly
produced in lymph node cell cultures from egg-injected mice. This
"early" IL-12 primes for the production of IL-6 and IFN-
, for in
IL-12-/- mice egg injection fails to stimulate increased
production of either of these cytokines. Furthermore, IL-6 also
up-regulates IL-10 production which, together with IL-6, negatively
regulates IL-12 and IFN- production. Finally, IL-10 down-regulates
the production of its inducer, IL-6. These data indicate that the
anti-inflammatory role of IL-6 may be effected through negative
regulation of type 1 (IFN-) and type 1-associated (IL-12) cytokines
either directly (by IL-6) or indirectly (through the induction of
IL-10) and suggest that one mechanism by which eggs may support the
development of Th2 responses is through the negative regulation of the
type 1 response.
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