| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, and Cincinnati Veterans Administration Medical Center, Cincinnati, OH 45220;
Genetics Institute, Cambridge, MA 02140;
University of Pennsylvania School of Medicine, Philadelphia, PA 19104; and
§
U.S. Department of Agriculture, Beltsville, MD 20705
Although in vitro development of a Th2 response from naive CD4+ T cells is Stat6 dependent, mice immunized with a goat Ab to mouse IgD have been reported to produce a normal primary IL-4 response in Stat6-deficient mice. Experiments have now been performed with mice immunized with more conventional Ags or inoculated with nematode parasites to account for this apparent discrepancy. The ability of an immunogen to induce a primary in vivo IL-4 response in Stat6-deficient mice was found to vary directly with its ability to induce a strong type 2 cytokine-biased response in normal mice. Even immunogens, however, that induce strong primary IL-4 responses in Stat6-deficient mice induce poor memory IL-4 responses in these mice. Consistent with this, Stat6-deficient CD4+ T cells make relatively normal IL-4 responses when stimulated in vitro for 3 days with anti-CD3 and anti-CD28, but poor IL-4 responses if they are later restimulated with anti-CD3. Thus, Stat6 signaling enhances primary IL-4 responses that are made as part of a type 0 cytokine response (mixed type 1 and type 2) and is required for normal development or survival of Th2 memory cells.
This article has been cited by other articles:
|
|
 |
|
  T. G. Jones, J. Hallgren, A. Humbles, T. Burwell, F. D. Finkelman, P. Alcaide, K. F. Austen, and M. F. Gurish Antigen-Induced Increases in Pulmonary Mast Cell Progenitor Numbers Depend on IL-9 and CD1d-Restricted NKT Cells J. Immunol., October 15, 2009; 183(8): 5251 - 5260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Y. Wan and R. A. Flavell How Diverse--CD4 Effector T Cells and their Functions J Mol Cell Biol, October 1, 2009; 1(1): 20 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Okamoto, H. Matsuda, A. Joetham, J. J. Lucas, J. Domenico, K. Yasutomo, K. Takeda, and E. W. Gelfand Jagged1 on Dendritic Cells and Notch on CD4+ T Cells Initiate Lung Allergic Responsiveness by Inducing IL-4 Production J. Immunol., September 1, 2009; 183(5): 2995 - 3003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Massacand, R. C. Stettler, R. Meier, N. E. Humphreys, R. K. Grencis, B. J. Marsland, and N. L. Harris Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function PNAS, August 18, 2009; 106(33): 13968 - 13973. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Speiran, D. P. Bailey, J. Fernando, M. Macey, B. Barnstein, M. Kolawole, D. Curley, S. S. Watowich, P. J. Murray, C. Oskeritzian, et al. Endogenous suppression of mast cell development and survival by IL-4 and IL-10 J. Leukoc. Biol., May 1, 2009; 85(5): 826 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Morris, S. M. Heidorn, D. R. Herbert, C. Perkins, D. A. Hildeman, M. V. Khodoun, and F. D. Finkelman Endogenously Produced IL-4 Nonredundantly Stimulates CD8+ T Cell Proliferation J. Immunol., February 1, 2009; 182(3): 1429 - 1438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Scheinman and O. Avni Transcriptional Regulation of Gata3 in T Helper Cells by the Integrated Activities of Transcription Factors Downstream of the Interleukin-4 Receptor and T Cell Receptor J. Biol. Chem., January 30, 2009; 284(5): 3037 - 3048. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Zhou, D. C. Newcomb, M. L. Moore, K. Goleniewska, J. F. O'Neal, and R. S. Peebles Jr. Cyclooxygenase Inhibition during Allergic Sensitization Increases STAT6-Independent Primary and Memory Th2 Responses J. Immunol., October 15, 2008; 181(8): 5360 - 5367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhu and W. E. Paul CD4 T cells: fates, functions, and faults Blood, September 1, 2008; 112(5): 1557 - 1569. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. van Panhuys, S.-C. Tang, M. Prout, M. Camberis, D. Scarlett, J. Roberts, J. Hu-Li, W. E. Paul, and G. Le Gros In vivo studies fail to reveal a role for IL-4 or STAT6 signaling in Th2 lymphocyte differentiation PNAS, August 26, 2008; 105(34): 12423 - 12428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Wiethe, A. Debus, M. Mohrs, A. Steinkasserer, M. Lutz, and A. Gessner Dendritic Cell Differentiation State and Their Interaction with NKT Cells Determine Th1/Th2 Differentiation in the Murine Model of Leishmania major Infection J. Immunol., April 1, 2008; 180(7): 4371 - 4381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. R. Herbert, T. Orekov, C. Perkins, M. E. Rothenberg, and F. D. Finkelman IL-4R{alpha} Expression by Bone Marrow-Derived Cells Is Necessary and Sufficient for Host Protection against Acute Schistosomiasis J. Immunol., April 1, 2008; 180(7): 4948 - 4955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. S. King, A. M. Knorn, C. Ohnmacht, and D. Voehringer Accumulation of Effector CD4 T Cells during Type 2 Immune Responses Is Negatively Regulated by Stat6 J. Immunol., January 15, 2008; 180(2): 754 - 763. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Khodoun, C. Lewis, J.-Q. Yang, T. Orekov, C. Potter, T. Wynn, M. Mentink-Kane, G. K. Khurana Hershey, M. Wills-Karp, and F. D. Finkelman Differences in Expression, Affinity, and Function of Soluble (s)IL-4R{alpha} and sIL-13R{alpha}2 Suggest Opposite Effects on Allergic Responses J. Immunol., November 15, 2007; 179(10): 6429 - 6438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Balic, Y. M. Harcus, M. D. Taylor, F. Brombacher, and R. M. Maizels IL-4R signaling is required to induce IL-10 for the establishment of Th2 dominance Int. Immunol., October 1, 2006; 18(10): 1421 - 1431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Voehringer, T. A. Reese, X. Huang, K. Shinkai, and R. M. Locksley Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system J. Exp. Med., June 12, 2006; 203(6): 1435 - 1446. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. So, J. Song, K. Sugie, A. Altman, and M. Croft Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment PNAS, March 7, 2006; 103(10): 3740 - 3745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sasaki, T. Yoshimoto, H. Maruyama, T. Tegoshi, N. Ohta, N. Arizono, and K. Nakanishi IL-18 with IL-2 protects against Strongyloides venezuelensis infection by activating mucosal mast cell-dependent type 2 innate immunity J. Exp. Med., September 6, 2005; 202(5): 607 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Su, M. Segura, K. Morgan, J. C. Loredo-Osti, and M. M. Stevenson Impairment of Protective Immunity to Blood-Stage Malaria by Concurrent Nematode Infection Infect. Immun., June 1, 2005; 73(6): 3531 - 3539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Liu, Q. Liu, H. Hamed, R. M. Anthony, A. Foster, F. D. Finkelman, J. F. Urban Jr, and W. C. Gause IL-2 and Autocrine IL-4 Drive the In Vivo Development of Antigen-Specific Th2 T Cells Elicited by Nematode Parasites J. Immunol., February 15, 2005; 174(4): 2242 - 2249. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Sanchez-Guajardo, J. A. M. Borghans, M.-E. Marquez, S. Garcia, and A. A. Freitas Different Competitive Capacities of Stat4- and Stat6-Deficient CD4+ T Cells during Lymphophenia-Driven Proliferation J. Immunol., February 1, 2005; 174(3): 1178 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. V. Khodoun, T. Orekhova, C. Potter, S. Morris, and F. D. Finkelman Basophils Initiate IL-4 Production during a Memory T-dependent Response J. Exp. Med., October 4, 2004; 200(7): 857 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Nagarkatti, C. B-Rao, V. Vijayan, S. K. Sharma, and B. Ghosh Signal Transducer and Activator of Transcription 6 Haplotypes and Asthma in the Indian Population Am. J. Respir. Cell Mol. Biol., September 1, 2004; 31(3): 317 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Min, M. Prout, J. Hu-Li, J. Zhu, D. Jankovic, E. S. Morgan, J. F. Urban Jr., A. M. Dvorak, F. D. Finkelman, G. LeGros, et al. Basophils Produce IL-4 and Accumulate in Tissues after Infection with a Th2-inducing Parasite J. Exp. Med., August 16, 2004; 200(4): 507 - 517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Jankovic, M. C. Kullberg, P. Caspar, and A. Sher Parasite-Induced Th2 Polarization Is Associated with Down-Regulated Dendritic Cell Responsiveness to Th1 Stimuli and a Transient Delay in T Lymphocyte Cycling J. Immunol., August 15, 2004; 173(4): 2419 - 2427. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Liu, C. Arseculeratne, Z. Liu, J. Whitmire, M. J. Grusby, F. D. Finkelman, T. N. Darling, A. W. Cheever, J. Swearengen, J. F. Urban, et al. Simultaneous Deficiency in CD28 and STAT6 Results in Chronic Ectoparasite-Induced Inflammatory Skin Disease Infect. Immun., July 1, 2004; 72(7): 3706 - 3715. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamashita, M. Ukai-Tadenuma, T. Miyamoto, K. Sugaya, H. Hosokawa, A. Hasegawa, M. Kimura, M. Taniguchi, J. DeGregori, and T. Nakayama Essential Role of GATA3 for the Maintenance of Type 2 Helper T (Th2) Cytokine Production and Chromatin Remodeling at the Th2 Cytokine Gene Loci J. Biol. Chem., June 25, 2004; 279(26): 26983 - 26990. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. Madden, K. A. Yeung, A. Zhao, W. C. Gause, F. D. Finkelman, I. M. Katona, J. F. Urban Jr., and T. Shea-Donohue Enteric Nematodes Induce Stereotypic STAT6-Dependent Alterations in Intestinal Epithelial Cell Function J. Immunol., May 1, 2004; 172(9): 5616 - 5621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Chitnis, A. D. Salama, M. J. Grusby, M. H. Sayegh, and S. J. Khoury Defining Th1 and Th2 Immune Responses in a Reciprocal Cytokine Environment In Vivo J. Immunol., April 1, 2004; 172(7): 4260 - 4265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Cote-Sierra, G. Foucras, L. Guo, L. Chiodetti, H. A. Young, J. Hu-Li, J. Zhu, and W. E. Paul Interleukin 2 plays a central role in Th2 differentiation PNAS, March 16, 2004; 101(11): 3880 - 3885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Nath, S. Giri, R. Prasad, A. K. Singh, and I. Singh Potential Targets of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitor for Multiple Sclerosis Therapy J. Immunol., January 15, 2004; 172(2): 1273 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Monick, L. Samavati, N. S. Butler, M. Mohning, L. S. Powers, T. Yarovinsky, D. R. Spitz, and G. W. Hunninghake Intracellular Thiols Contribute to Th2 Function via a Positive Role in IL-4 Production J. Immunol., November 15, 2003; 171(10): 5107 - 5115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. O. Jacob, S. Zang, L. Li, V. Ciobanu, F. Quismorio, A. Mizutani, M. Satoh, and M. Koss Pivotal Role of Stat4 and Stat6 in the Pathogenesis of the Lupus-Like Disease in the New Zealand Mixed 2328 Mice J. Immunol., August 1, 2003; 171(3): 1564 - 1571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Spencer, L. Shultz, and T. V. Rajan T Cells Are Required for Host Protection against Brugia malayi but Need Not Produce or Respond to Interleukin-4 Infect. Immun., June 1, 2003; 71(6): 3097 - 3106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Noben-Trauth, R. Lira, H. Nagase, W. E. Paul, and D. L. Sacks The Relative Contribution of IL-4 Receptor Signaling and IL-10 to Susceptibility to Leishmania major J. Immunol., May 15, 2003; 170(10): 5152 - 5158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Wood, M. J. Whitters, B. A. Jacobson, J. Witek, J. P. Sypek, M. Kasaian, M. J. Eppihimer, M. Unger, T. Tanaka, S. J. Goldman, et al. Enhanced Interleukin (IL)-13 Responses in Mice Lacking IL-13 Receptor {alpha} 2 J. Exp. Med., March 17, 2003; 197(6): 703 - 709. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Jung, R. LaCourse, L. Ryan, and R. J. North Evidence Inconsistent with a Negative Influence of T Helper 2 Cells on Protection Afforded by a Dominant T Helper 1 Response against Mycobacterium tuberculosis Lung Infection in Mice Infect. Immun., November 1, 2002; 70(11): 6436 - 6443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-C. Chang, S. Zhang, and M. H. Kaplan Neonatal Tolerance in the Absence of Stat4- and Stat6- Dependent Th Cell Differentiation J. Immunol., October 15, 2002; 169(8): 4124 - 4128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Cunningham, P. G. Fallon, M. Khan, S. Vacheron, H. Acha-Orbea, I. C. M. MacLennan, A. N. McKenzie, and K.-M. Toellner Th2 Activities Induced During Virgin T Cell Priming in the Absence of IL-4, IL-13, and B Cells J. Immunol., September 15, 2002; 169(6): 2900 - 2906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Brogdon, D. Leitenberg, and K. Bottomly The Potency of TCR Signaling Differentially Regulates NFATc/p Activity and Early IL-4 Transcription in Naive CD4+ T Cells J. Immunol., April 15, 2002; 168(8): 3825 - 3832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rodriguez-Sosa, J. R. David, R. Bojalil, A. R. Satoskar, and L. I. Terrazas Cutting Edge: Susceptibility to the Larval Stage of the Helminth Parasite Taenia crassiceps Is Mediated by Th2 Response Induced Via STAT6 Signaling J. Immunol., April 1, 2002; 168(7): 3135 - 3139. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Ise, M. Totsuka, Y. Sogawa, A. Ametani, S. Hachimura, T. Sato, Y. Kumagai, S. Habu, and S. Kaminogawa Naive CD4+ T Cells Exhibit Distinct Expression Patterns of Cytokines and Cell Surface Molecules on Their Primary Responses to Varying Doses of Antigen J. Immunol., April 1, 2002; 168(7): 3242 - 3250. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gorak-Stolinska, J.-P. Truman, D. M. Kemeny, and A. Noble Activation-induced cell death of human T-cell subsets is mediated by Fas and granzyme B but is independent of TNF-{alpha} J. Leukoc. Biol., November 1, 2001; 70(5): 756 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Shea-Donohue, C. Sullivan, F. D. Finkelman, K. B. Madden, S. C. Morris, J. Goldhill, V. Pineiro-Carrero, and J. F. Urban Jr. The Role of IL-4 in Heligmosomoides polygyrus-Induced Alterations in Murine Intestinal Epithelial Cell Function J. Immunol., August 15, 2001; 167(4): 2234 - 2239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Mullen, F. A. High, A. S. Hutchins, H. W. Lee, A. V. Villarino, D. M. Livingston, A. L. Kung, N. Cereb, T.-P. Yao, S. Y. Yang, et al. Role of T-bet in Commitment of TH1 Cells Before IL-12-Dependent Selection Science, June 8, 2001; 292(5523): 1907 - 1910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Farrar, W. Ouyang, M. Lohning, M. Assenmacher, A. Radbruch, O. Kanagawa, and K. M. Murphy An Instructive Component in T Helper Cell Type 2 (Th2) Development Mediated by Gata-3 J. Exp. Med., March 5, 2001; 193(5): 643 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ostrand-Rosenberg, M. J. Grusby, and V. K. Clements Cutting Edge: STAT6-Deficient Mice Have Enhanced Tumor Immunity to Primary and Metastatic Mammary Carcinoma J. Immunol., December 1, 2000; 165(11): 6015 - 6019. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. H. Glimcher and K. M. Murphy Lineage commitment in the immune system: the T helper lymphocyte grows up Genes & Dev., July 15, 2000; 14(14): 1693 - 1711. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
