|
|
||||||||
CUTTING EDGE |
Department of Biochemistry, Fukushima Medical University School of Medicine, Fukushima, Japan
Both ficolins and mannose-binding lectin (MBL) are lectins characterized by the presence of collagen-like and carbohydrate-binding domains in a subunit, although their carbohydrate-binding moieties are quite different. A fibrinogen-like domain is in ficolins, and a carbohydrate recognition domain is in MBL. On binding to pathogens, human MBL activates the complement system via the lectin pathway in association with two types of MBL-associated serine proteases (MASP), MASP-1 and MASP-2 and its truncated form, small MBL-associated protein (sMAP, also called MAp19). We report here that ficolin/P35, a human serum ficolin, was found to copurify with MASPs and sMAP. MASPs that were complexed with ficolin/P35 exhibited proteolytic activities against complement components C4, C2, and C3. The ficolin/P35-MASPs-sMAP complex that was bound to Salmonella typhimurium activated complement. These findings indicate that ficolin/P35 is a second collagenous lectin capable of activating the lectin pathway and thus plays a role in innate immunity.
This article has been cited by other articles:
![]() |
M. Lacroix, C. Dumestre-Perard, G. Schoehn, G. Houen, J.-Y. Cesbron, G. J. Arlaud, and N. M. Thielens Residue Lys57 in the Collagen-Like Region of Human L-Ficolin and Its Counterpart Lys47 in H-Ficolin Play a Key Role in the Interaction with the Mannan-Binding Lectin-Associated Serine Proteases and the Collectin Receptor Calreticulin J. Immunol., January 1, 2009; 182(1): 456 - 465. [Abstract] [Full Text] [PDF] |
||||
![]() |
F. Teillet, C. Gaboriaud, M. Lacroix, L. Martin, G. J. Arlaud, and N. M. Thielens Crystal Structure of the CUB1-EGF-CUB2 Domain of Human MASP-1/3 and Identification of Its Interaction Sites with Mannan-binding Lectin and Ficolins J. Biol. Chem., September 12, 2008; 283(37): 25715 - 25724. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Liu, J.-Y. Zhu, and Z.-X. Niu Molecular Structure and Expression of Anthropic, Ovine, and Murine Forms of Complement Receptor Type 2 Clin. Vaccine Immunol., June 1, 2008; 15(6): 901 - 910. [Full Text] [PDF] |
||||
![]() |
E. Shagdarsuren, K. Bidzhekov, Y. Djalali-Talab, E. A. Liehn, M. Hristov, R. A. Matthijsen, W. A. Buurman, A. Zernecke, and C. Weber C1-Esterase Inhibitor Protects Against Neointima Formation After Arterial Injury in Atherosclerosis-Prone Mice Circulation, January 1, 2008; 117(1): 70 - 78. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Roos, M. R. Daha, J. van Pelt, and S. P. Berger Mannose-binding lectin and the kidney Nephrol. Dial. Transplant., December 1, 2007; 22(12): 3370 - 3377. [Full Text] [PDF] |
||||
![]() |
S. Mihai, M. T. Chiriac, K. Takahashi, J. M. Thurman, V. M. Holers, D. Zillikens, M. Botto, and C. Sitaru The Alternative Pathway of Complement Activation Is Critical for Blister Induction in Experimental Epidermolysis Bullosa Acquisita J. Immunol., May 15, 2007; 178(10): 6514 - 6521. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Wallis, A. W. Dodds, D. A. Mitchell, R. B. Sim, K. B. M. Reid, and W. J. Schwaeble Molecular Interactions between MASP-2, C4, and C2 and Their Activation Fragments Leading to Complement Activation via the Lectin Pathway J. Biol. Chem., March 16, 2007; 282(11): 7844 - 7851. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Tanio, S. Kondo, S. Sugio, and T. Kohno Trivalent Recognition Unit of Innate Immunity System: CRYSTAL STRUCTURE OF TRIMERIC HUMAN M-FICOLIN FIBRINOGEN-LIKE DOMAIN J. Biol. Chem., February 9, 2007; 282(6): 3889 - 3895. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Roos, M. P. Rastaldi, N. Calvaresi, B. D. Oortwijn, N. Schlagwein, D. J. van Gijlswijk-Janssen, G. L. Stahl, M. Matsushita, T. Fujita, C. van Kooten, et al. Glomerular Activation of the Lectin Pathway of Complement in IgA Nephropathy Is Associated with More Severe Renal Disease J. Am. Soc. Nephrol., June 1, 2006; 17(6): 1724 - 1734. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. M. Thurman and V. M. Holers The Central Role of the Alternative Complement Pathway in Human Disease J. Immunol., February 1, 2006; 176(3): 1305 - 1310. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Rossi, F. Teillet, N. M. Thielens, I. Bally, and G. J. Arlaud Functional Characterization of Complement Proteases C1s/Mannan-binding Lectin-associated Serine Protease-2 (MASP-2) Chimeras Reveals the Higher C4 Recognition Efficacy of the MASP-2 Complement Control Protein Modules J. Biol. Chem., December 23, 2005; 280(51): 41811 - 41818. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Liu, Y. Endo, D. Iwaki, M. Nakata, M. Matsushita, I. Wada, K. Inoue, M. Munakata, and T. Fujita Human M-Ficolin Is a Secretory Protein That Activates the Lectin Complement Pathway J. Immunol., September 1, 2005; 175(5): 3150 - 3156. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Hummelshoj, L. Munthe-Fog, H. O. Madsen, T. Fujita, M. Matsushita, and P. Garred Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2 Hum. Mol. Genet., June 15, 2005; 14(12): 1651 - 1658. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. J. Lynch, S.-u.-H. Khan, C. M. Stover, S. M. Sandrini, D. Marston, J. S. Presanis, and W. J. Schwaeble Composition of the Lectin Pathway of Complement in Gallus gallus: Absence of Mannan-Binding Lectin-Associated Serine Protease-1 in Birds J. Immunol., April 15, 2005; 174(8): 4998 - 5006. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Krarup, U. B. S. Sorensen, M. Matsushita, J. C. Jensenius, and S. Thiel Effect of Capsulation of Opportunistic Pathogenic Bacteria on Binding of the Pattern Recognition Molecules Mannan-Binding Lectin, L-Ficolin, and H-Ficolin Infect. Immun., February 1, 2005; 73(2): 1052 - 1060. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Aoyagi, E. E. Adderson, J. G. Min, M. Matsushita, T. Fujita, S. Takahashi, Y. Okuwaki, and J. F. Bohnsack Role of L-Ficolin/Mannose-Binding Lectin-Associated Serine Protease Complexes in the Opsonophagocytosis of Type III Group B Streptococci J. Immunol., January 1, 2005; 174(1): 418 - 425. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Krarup, S. Thiel, A. Hansen, T. Fujita, and J. C. Jensenius L-ficolin Is a Pattern Recognition Molecule Specific for Acetyl Groups J. Biol. Chem., November 12, 2004; 279(46): 47513 - 47519. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Windbichler, B. Echtenacher, T. Hehlgans, J. C. Jensenius, W. Schwaeble, and D. N. Mannel Involvement of the Lectin Pathway of Complement Activation in Antimicrobial Immune Defense during Experimental Septic Peritonitis Infect. Immun., September 1, 2004; 72(9): 5247 - 5252. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. A. Gregory, N. M. Thielens, M. Matsushita, R. Sorensen, G. J. Arlaud, J. C. Fontecilla-Camps, and C. Gaboriaud The X-ray Structure of Human Mannan-binding Lectin-associated Protein 19 (MAp19) and Its Interaction Site with Mannan-binding Lectin and L-ficolin J. Biol. Chem., July 9, 2004; 279(28): 29391 - 29397. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Matsushita, A. Matsushita, Y. Endo, M. Nakata, N. Kojima, T. Mizuochi, and T. Fujita Origin of the classical complement pathway: Lamprey orthologue of mammalian C1q acts as a lectin PNAS, July 6, 2004; 101(27): 10127 - 10131. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. G. Ma, M. Y. Cho, M. Zhao, J. W. Park, M. Matsushita, T. Fujita, and B. L. Lee Human Mannose-binding Lectin and L-Ficolin Function as Specific Pattern Recognition Proteins in the Lectin Activation Pathway of Complement J. Biol. Chem., June 11, 2004; 279(24): 25307 - 25312. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. Wallis, J. M. Shaw, J. Uitdehaag, C.-B. Chen, D. Torgersen, and K. Drickamer Localization of the Serine Protease-binding Sites in the Collagen-like Domain of Mannose-binding Protein: INDIRECT EFFECTS OF NATURALLY OCCURRING MUTATIONS ON PROTEASE BINDING AND ACTIVATION J. Biol. Chem., April 2, 2004; 279(14): 14065 - 14073. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Zundel, S. Cseh, M. Lacroix, M. R. Dahl, M. Matsushita, J.-P. Andrieu, W. J. Schwaeble, J. C. Jensenius, T. Fujita, G. J. Arlaud, et al. Characterization of Recombinant Mannan-Binding Lectin-Associated Serine Protease (MASP)-3 Suggests an Activation Mechanism Different from That of MASP-1 and MASP-2 J. Immunol., April 1, 2004; 172(7): 4342 - 4350. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Ohashi and H. P. Erickson The Disulfide Bonding Pattern in Ficolin Multimers J. Biol. Chem., February 20, 2004; 279(8): 6534 - 6539. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. J. Lynch, S. Roscher, T. Hartung, S. Morath, M. Matsushita, D. N. Maennel, M. Kuraya, T. Fujita, and W. J. Schwaeble L-Ficolin Specifically Binds to Lipoteichoic Acid, a Cell Wall Constituent of Gram-Positive Bacteria, and Activates the Lectin Pathway of Complement J. Immunol., January 15, 2004; 172(2): 1198 - 1202. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Endo, M. Nonaka, H. Saiga, Y. Kakinuma, A. Matsushita, M. Takahashi, M. Matsushita, and T. Fujita Origin of Mannose-Binding Lectin-Associated Serine Protease (MASP)-1 and MASP-3 Involved in the Lectin Complement Pathway Traced Back to the Invertebrate, Amphioxus J. Immunol., May 1, 2003; 170(9): 4701 - 4707. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. S. Quesenberry, H. Ahmed, M. T. Elola, N. O'Leary, and G. R. Vasta Diverse Lectin Repertoires in Tunicates Mediate Broad Recognition and Effector Innate Immune Responses Integr. Comp. Biol., April 1, 2003; 43(2): 323 - 330. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Kuraya, M. Matsushita, Y. Endo, S. Thiel, and T. Fujita Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G Int. Immunol., January 1, 2003; 15(1): 109 - 117. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Cseh, L. Vera, M. Matsushita, T. Fujita, G. J. Arlaud, and N. M. Thielens Characterization of the Interaction Between L-Ficolin/P35 and Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 J. Immunol., November 15, 2002; 169(10): 5735 - 5743. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Neth, D. L. Jack, M. Johnson, N. J. Klein, and M. W. Turner Enhancement of Complement Activation and Opsonophagocytosis by Complexes of Mannose-Binding Lectin with Mannose-Binding Lectin-Associated Serine Protease After Binding to Staphylococcus aureus J. Immunol., October 15, 2002; 169(8): 4430 - 4436. [Abstract] [Full Text] [PDF] |
||||
![]() |
Y. Endo, M. Takahashi, M. Kuraya, M. Matsushita, C. M. Stover, W. J. Schwaeble, and T. Fujita Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter Int. Immunol., October 1, 2002; 14(10): 1193 - 1201. [Abstract] [Full Text] [PDF] |
||||
![]() |
G. Dimopoulos, G. K. Christophides, S. Meister, J. Schultz, K. P. White, C. Barillas-Mury, and F. C. Kafatos Genome expression analysis of Anopheles gambiae: Responses to injury, bacterial challenge, and malaria infection PNAS, June 25, 2002; 99(13): 8814 - 8819. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Gulati, K. Sastry, J. C. Jensenius, P. A. Rice, and S. Ram Regulation of the Mannan-Binding Lectin Pathway of Complement on Neisseria gonorrhoeae by C1-Inhibitor and {alpha}2-Macroglobulin J. Immunol., April 15, 2002; 168(8): 4078 - 4086. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Matsushita, M. Kuraya, N. Hamasaki, M. Tsujimura, H. Shiraki, and T. Fujita Activation of the Lectin Complement Pathway by H-Ficolin (Hakata Antigen) J. Immunol., April 1, 2002; 168(7): 3502 - 3506. [Abstract] [Full Text] [PDF] |
||||
![]() |
I. Celik, C. Stover, M. Botto, S. Thiel, S. Tzima, D. Kunkel, M. Walport, W. Lorenz, and W. Schwaeble Role of the Classical Pathway of Complement Activation in Experimentally Induced Polymicrobial Peritonitis Infect. Immun., December 1, 2001; 69(12): 7304 - 7309. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Sekine, A. Kenjo, K. Azumi, G. Ohi, M. Takahashi, R. Kasukawa, N. Ichikawa, M. Nakata, T. Mizuochi, M. Matsushita, et al. An Ancient Lectin-Dependent Complement System in an Ascidian: Novel Lectin Isolated from the Plasma of the Solitary Ascidian, Halocynthia roretzi J. Immunol., October 15, 2001; 167(8): 4504 - 4510. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. J. Walport Complement- Second of Two Parts N. Engl. J. Med., April 12, 2001; 344(15): 1140 - 1144. [Full Text] [PDF] |
||||
![]() |
M. Matsushita, S. Thiel, J. C. Jensenius, I. Terai, and T. Fujita Proteolytic Activities of Two Types of Mannose-Binding Lectin-Associated Serine Protease J. Immunol., September 1, 2000; 165(5): 2637 - 2642. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Thiel, S. V. Petersen, T. Vorup-Jensen, M. Matsushita, T. Fujita, C. M. Stover, W. J. Schwaeble, and J. C. Jensenius Interaction of C1q and Mannan-Binding Lectin (MBL) with C1r, C1s, MBL-Associated Serine Proteases 1 and 2, and the MBL-Associated Protein MAp19 J. Immunol., July 15, 2000; 165(2): 878 - 887. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Kenjo, M. Takahashi, M. Matsushita, Y. Endo, M. Nakata, T. Mizuochi, and T. Fujita Cloning and Characterization of Novel Ficolins from the Solitary Ascidian, Halocynthia roretzi J. Biol. Chem., June 1, 2001; 276(23): 19959 - 19965. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Tsuji, J. Uehori, M. Matsumoto, Y. Suzuki, A. Matsuhisa, K. Toyoshima, and T. Seya Human Intelectin Is a Novel Soluble Lectin That Recognizes Galactofuranose in Carbohydrate Chains of Bacterial Cell Wall J. Biol. Chem., June 22, 2001; 276(26): 23456 - 23463. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |