The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     
 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Matsumoto, Y.
Right arrow Articles by Sugisaki, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Matsumoto, Y.
Right arrow Articles by Sugisaki, M.
The Journal of Immunology, 2000, 164: 2248-2254.
Copyright © 2000 by The American Association of Immunologists

Successful TCR-Based Immunotherapy for Autoimmune Myocarditis with DNA Vaccines After Rapid Identification of Pathogenic TCR1

Yoh Matsumoto, Youngheun Jee and Mayumi Sugisaki

Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan

The identification of TCRs of autoimmune disease-inducing T cells within a short period of time is a key factor for designing TCR-based immunotherapy during the course of the disease. In this study, we show that experimental autoimmune carditis-associated TCRs, Vß8.2 and Vß10, were determined by complementarity-determining region 3 (CDR3)-spectratyping analysis and subsequent sequencing of the CDR3 region of spectratype-derived TCR clones. Immunotherapy targeting both Vß8.2 and Vß10 TCRs using mAbs and DNA vaccines significantly reduced the histological severity of experimental autoimmune carditis and completely suppressed the inflammation in some animals. Since depletion or suppression of one of two types of effector cells does not improve the severity of the disease significantly, combined TCR-based immunotherapy should be considered as a primary therapy for T cell-mediated autoimmune diseases. TCR-based immunotherapy after rapid identification of autoimmune disease-associated TCRs by CDR3 spectratyping can be applicable, not only to animal, but also to human autoimmune diseases whose pathomechanism is poorly understood.




This article has been cited by other articles:


Home page
Eur J Heart FailHome page
J.-i. Suzuki, M. Ogawa, H. Futamatsu, H. Kosuge, Y. M. Sagesaka, and M. Isobe
Tea catechins improve left ventricular dysfunction, suppress myocardial inflammation and fibrosis, and alter cytokine expression in rat autoimmune myocarditis
Eur J Heart Fail, February 1, 2007; 9(2): 152 - 159.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Pathol.Home page
Y. Matsumoto, I.-K. Park, and K. Kohyama
B-Cell Epitope Spreading Is a Critical Step for the Switch from C-Protein-Induced Myocarditis to Dilated Cardiomyopathy
Am. J. Pathol., January 1, 2007; 170(1): 43 - 51.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
Y. Okura, A. Miyakoshi, K. Kohyama, I.-K. Park, M. Staufenbiel, and Y. Matsumoto
Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: Long-term effects and safety
PNAS, June 20, 2006; 103(25): 9619 - 9624.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
Y. Matsumoto, H. Matsuo, H. Sakuma, I.-K. Park, Y. Tsukada, K. Kohyama, T. Kondo, S. Kotorii, and N. Shibuya
CDR3 Spectratyping Analysis of the TCR Repertoire in Myasthenia Gravis.
J. Immunol., April 15, 2006; 176(8): 5100 - 5107.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart JHome page
Y. Asaumi, S. Yasuda, I. Morii, H. Kakuchi, Y. Otsuka, A. Kawamura, Y. Sasako, T. Nakatani, H. Nonogi, and S. Miyazaki
Favourable clinical outcome in patients with cardiogenic shock due to fulminant myocarditis supported by percutaneous extracorporeal membrane oxygenation
Eur. Heart J., October 2, 2005; 26(20): 2185 - 2192.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
H. Sakuma, K. Kohyama, Y. Jee, and Y. Matsumoto
Tracking of V{beta}8.2-Positive Encephalitogenic T Cells by Complementarity-Determining Region 3 Spectratyping and Subsequent Southern Blot Hybridization in Lewis Rats after Neuroantigen Sensitization
J. Immunol., October 1, 2004; 173(7): 4516 - 4522.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
Y. Matsumoto, Y. Tsukada, A. Miyakoshi, H. Sakuma, and K. Kohyama
C Protein-Induced Myocarditis and Subsequent Dilated Cardiomyopathy: Rescue from Death and Prevention of Dilated Cardiomyopathy by Chemokine Receptor DNA Therapy
J. Immunol., September 1, 2004; 173(5): 3535 - 3541.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
H. Wu, G. Walters, J. F. Knight, and S. I. Alexander
DNA Vaccination Against Specific Pathogenic TCRs Reduces Proteinuria in Active Heymann Nephritis by Inducing Specific Autoantibodies
J. Immunol., November 1, 2003; 171(9): 4824 - 4829.
[Abstract] [Full Text] [PDF]


Home page
Cardiovasc ResHome page
J. W Mason
Myocarditis and dilated cardiomyopathy: An inflammatory link
Cardiovasc Res, October 15, 2003; 60(1): 5 - 10.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
A. Miyakoshi, W. K. Yoon, Y. Jee, and Y. Matsumoto
Characterization of the Antigen Specificity and TCR Repertoire, and TCR-Based DNA Vaccine Therapy in Myelin Basic Protein-Induced Autoimmune Encephalomyelitis in DA Rats
J. Immunol., June 15, 2003; 170(12): 6371 - 6378.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
Y. Matsumoto, W. K. Yoon, Y. Jee, K. Fujihara, T. Misu, S. Sato, I. Nakashima, and Y. Itoyama
Complementarity-Determining Region 3 Spectratyping Analysis of the TCR Repertoire in Multiple Sclerosis
J. Immunol., May 1, 2003; 170(9): 4846 - 4853.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
T. A. Braciak, B. Pedersen, J. Chin, C. Hsiao, E. S. Ward, I. Maricic, A. Jahng, F. L. Graham, J. Gauldie, E. E. Sercarz, et al.
Protection Against Experimental Autoimmune Encephalomyelitis Generated by a Recombinant Adenovirus Vector Expressing the V{beta}8.2 TCR Is Disrupted by Coadministration with Vectors Expressing Either IL-4 or -10
J. Immunol., January 15, 2003; 170(2): 765 - 774.
[Abstract] [Full Text] [PDF]


Home page
Eur Heart J SupplHome page
W. Poller, H. Fechner, M. Noutsias, C. Tschoepe, M. Pauschinger, and H.-P. Schultheiss
The molecular basis of cardiotropic viral infections
Eur. Heart J. Suppl., December 1, 2002; 4(suppl_I): I18 - I30.
[Abstract] [PDF]


Home page
Eur Heart J SupplHome page
Y. Matsumoto
Clonality of T lymphocytes in inflammatory cardiomyopathy
Eur. Heart J. Suppl., December 1, 2002; 4(suppl_I): I46 - I48.
[Abstract] [PDF]


Home page
BloodHome page
K. Yoshida, T. Arai, J. Kaburaki, Y. Ikeda, Y. Kawakami, and M. Kuwana
Restricted T-cell receptor beta -chain usage by T cells autoreactive to beta 2-glycoprotein I in patients with antiphospholipid syndrome
Blood, April 1, 2002; 99(7): 2499 - 2504.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
P. P. Liu and J. W. Mason
Advances in the Understanding of Myocarditis
Circulation, August 28, 2001; 104(9): 1076 - 1082.
[Full Text] [PDF]


Home page
NEJMHome page
A. Davidson and B. Diamond
Autoimmune Diseases
N. Engl. J. Med., August 2, 2001; 345(5): 340 - 350.
[Full Text] [PDF]


Home page
Int ImmunolHome page
V. Kumar, J. Maglione, J. Thatte, B. Pederson, E. Sercarz, and E. S. Ward
Induction of a type 1 regulatory CD4 T cell response following V{beta}8.2 DNA vaccination results in immune deviation and protection from experimental autoimmune encephalomyelitis
Int. Immunol., June 1, 2001; 13(6): 835 - 841.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2000 by The American Association of Immunologists, Inc. All rights reserved.