HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kühn, K. Articles by Lotz, M. Search for Related Content PubMed PubMed Citation Articles by Kühn, K. Articles by Lotz, M.

IL-1ß Protects Human Chondrocytes from CD95-Induced Apoptosis¹

Division of Arthritis Research, Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037

This study addresses the effects of IL-1ß on apoptosis induced by agonistic anti-CD95 (Fas) Ab. IL-1ß inhibited anti-CD95 Ab-induced apoptosis in all preparations of normal human articular chondrocytes tested. Inhibitors of nitric oxide synthase or cyclooxygenase did not influence the protective effect of IL-1ß, indicating that nitric oxide and PGs were not involved in the modulation of CD95-induced apoptosis. However, when the IL-1ß-dependent induction of NF-B was inhibited, the antiapoptotic effect of IL-1ß was partially reversed, suggesting that NF-B-mediated gene activation is part of the protective mechanism. In addition, IL-1ß significantly increased the expression of Bcl-2. The protein tyrosine kinase inhibitor herbimycin A completely eliminated the protective effect of IL-1ß on CD95-induced apoptosis. These findings suggest that IL-1ß modulates the CD95 death cascade in chondrocytes by mechanisms that involve tyrosine phosphorylation events and NF-B-dependent gene activation.

This article has been cited by other articles:

				C.-Y. Yang, T.-H. Kuo, and L.-P. Ting Human Hepatitis B Viral e Antigen Interacts with Cellular Interleukin-1 Receptor Accessory Protein and Triggers Interleukin-1 Response J. Biol. Chem., November 10, 2006; 281(45): 34525 - 34536. [Abstract] [Full Text] [PDF]

				R. M Smith, S. Lecour, and M. N Sack Innate immunity and cardiac preconditioning: a putative intrinsic cardioprotective program Cardiovasc Res, August 15, 2002; 55(3): 474 - 482. [Abstract] [Full Text] [PDF]