| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Laboratoire Allergie, Centre Recherche du CHUM, Campus Notre-Dame, Université de Montréal, Montréal, Canada
Upon encounter with bacterial products, immature dendritic cells
(iDCs) release proinflammatory cytokines and develop into highly
stimulatory mature DCs. In the present study, we show that human
monocyte-derived DCs functionally express the CD47 Ag, a thrombospondin
receptor. Intact or F(ab')2 of CD47 mAb suppress
bacteria-induced production of IL-12, TNF-
, GM-CSF, and IL-6 by
iDCs. 4N1K, a peptide derived from the CD47-binding site of
thrombospondin, also inhibits cytokine release. The inhibition of IL-12
and TNF- is IL-10-independent inasmuch as IL-10 production is
down-modulated by CD47 mAb and blocking IL-10 mAb fails to restore
cytokine levels. CD47 ligation counteracts the phenotypic and
functional maturation of iDCs in that it prevents the up-regulation of
costimulatory molecules, the loss of endocytic activity, and the
acquisition of an increased capacity to stimulate T cell proliferation
and IFN-
production. Interestingly, regardless of CD47 mAb treatment
during DC maturation, mature DC restimulated by soluble CD40 ligand and
IFN-, to mimic DC/T interaction, produce less IL-12 and more IL-18
than iDCs. Finally, CD47 ligation on iDCs does not impair their
capacity to phagocytose apoptotic cells. We conclude that following
exposure to microorganisms, CD47 ligation may limit the intensity and
duration of the inflammatory response by preventing inflammatory
cytokine production by iDCs and favoring their maintenance in an
immature state.
This article has been cited by other articles:
|
|
 |
|
  N. Baba, S. Samson, R. Bourdet-Sicard, M. Rubio, and M. Sarfati Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells J. Leukoc. Biol., August 1, 2008; 84(2): 468 - 476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Su, M. Johansen, M. R. Looney, E. J. Brown, and M. A. Matthay CD47 Deficiency Protects Mice from Lipopolysaccharide-Induced Acute Lung Injury and Escherichia coli Pneumonia J. Immunol., May 15, 2008; 180(10): 6947 - 6953. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Isenberg, D. D. Roberts, and W. A. Frazier CD47: A New Target in Cardiovascular Therapy Arterioscler. Thromb. Vasc. Biol., April 1, 2008; 28(4): 615 - 621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Futagami, S. Sugita, J. Vega, K. Ishida, H. Takase, K. Maruyama, H. Aburatani, and M. Mochizuki Role of Thrombospondin-1 in T Cell Response to Ocular Pigment Epithelial Cells J. Immunol., June 1, 2007; 178(11): 6994 - 7005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Braun, L. Galibert, T. Nakajima, H. Saito, V. V. Quang, M. Rubio, and M. Sarfati Semimature Stage: A Checkpoint in a Dendritic Cell Maturation Program That Allows for Functional Reversion after Signal-Regulatory Protein-{alpha} Ligation and Maturation Signals J. Immunol., December 15, 2006; 177(12): 8550 - 8559. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Grimbert, S. Bouguermouh, N. Baba, T. Nakajima, Z. Allakhverdi, D. Braun, H. Saito, M. Rubio, G. Delespesse, and M. Sarfati Thrombospondin/CD47 Interaction: A Pathway to Generate Regulatory T Cells from Human CD4+CD25- T Cells in Response to Inflammation J. Immunol., September 15, 2006; 177(6): 3534 - 3541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hagnerud, P. P. Manna, M. Cella, A. Stenberg, W. A. Frazier, M. Colonna, and P.-A. Oldenborg Deficit of CD47 Results in a Defect of Marginal Zone Dendritic Cells, Blunted Immune Response to Particulate Antigen and Impairment of Skin Dendritic Cell Migration J. Immunol., May 15, 2006; 176(10): 5772 - 5778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Masli, B. Turpie, and J W. Streilein Thrombospondin orchestrates the tolerance-promoting properties of TGF{beta}-treated antigen-presenting cells Int. Immunol., May 1, 2006; 18(5): 689 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Sezaki, S. Hirohata, A. Iwabu, K. Nakamura, K. Toeda, T. Miyoshi, H. Yamawaki, K. Demircan, S. Kusachi, Y. Shiratori, et al. Thrombospondin-1 Is Induced in Rat Myocardial Infarction and Its Induction Is Accelerated by Ischemia/Reperfusion Experimental Biology and Medicine, October 1, 2005; 230(9): 621 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zhang, S. D. Tachado, N. Patel, J. Zhu, A. Imrich, P. Manfruelli, M. Cushion, T. B. Kinane, and H. Koziel Negative regulatory role of mannose receptors on human alveolar macrophage proinflammatory cytokine release in vitro J. Leukoc. Biol., September 1, 2005; 78(3): 665 - 674. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. P. Fraser, L. Stuart, and R. A. B. Ezekowitz TLR-independent pattern recognition receptors and anti-inflammatory mechanisms Innate Immunity, April 1, 2004; 10(2): 120 - 124. [Abstract] [PDF]
|
|
|
|
 |
|
 V. Doyen, M. Rubio, D. Braun, T. Nakajima, J. Abe, H. Saito, G. Delespesse, and M. Sarfati Thrombospondin 1 Is an Autocrine Negative Regulator of Human Dendritic Cell Activation J. Exp. Med., October 20, 2003; 198(8): 1277 - 1283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P. Manna and W. A. Frazier The Mechanism of CD47-Dependent Killing of T Cells: Heterotrimeric Gi-Dependent Inhibition of Protein Kinase A J. Immunol., April 1, 2003; 170(7): 3544 - 3553. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Morelli, A. T. Larregina, W. J. Shufesky, A. F. Zahorchak, A. J. Logar, G. D. Papworth, Z. Wang, S. C. Watkins, L. D. Falo Jr, and A. W. Thomson Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production Blood, January 15, 2003; 101(2): 611 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Mateo, E. J. Brown, G. Biron, M. Rubio, A. Fischer, F. L. Deist, and M. Sarfati Mechanisms of CD47-induced caspase-independent cell death in normal and leukemic cells: link between phosphatidylserine exposure and cytoskeleton organization Blood, September 26, 2002; 100(8): 2882 - 2890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. McGuirk, C. McCann, and K. H.G. Mills Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells: A Novel Strategy for Evasion of Protective T Helper Type 1 Responses by Bordetella pertussis J. Exp. Med., January 22, 2002; 195(2): 221 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Lipscomb and B. J. Masten Dendritic Cells: Immune Regulators in Health and Disease Physiol Rev, January 1, 2002; 82(1): 97 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-N. Avice, M. Rubio, M. Sergerie, G. Delespesse, and M. Sarfati Role of CD47 in the Induction of Human Naive T Cell Anergy J. Immunol., September 1, 2001; 167(5): 2459 - 2468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Latour, H. Tanaka, C. Demeure, V. Mateo, M. Rubio, E. J. Brown, C. Maliszewski, F. P. Lindberg, A. Oldenborg, A. Ullrich, et al. Bidirectional Negative Regulation of Human T and Dendritic Cells by CD47 and Its Cognate Receptor Signal-Regulator Protein-{alpha}: Down-Regulation of IL-12 Responsiveness and Inhibition of Dendritic Cell Activation J. Immunol., September 1, 2001; 167(5): 2547 - 2554. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Li, L. He, K. E. Wilson, and D. D. Roberts Thrombospondin-1 Inhibits TCR-Mediated T Lymphocyte Early Activation J. Immunol., February 15, 2001; 166(4): 2427 - 2436. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-N. Avice, M. Rubio, M. Sergerie, G. Delespesse, and M. Sarfati CD47 Ligation Selectively Inhibits the Development of Human Naive T Cells into Th1 Effectors J. Immunol., October 15, 2000; 165(8): 4624 - 4631. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. J. Chang, A. Wright, and J. Punnonen Monocyte-Derived CD1a+ and CD1a- Dendritic Cell Subsets Differ in Their Cytokine Production Profiles, Susceptibilities to Transfection, and Capacities to Direct Th Cell Differentiation J. Immunol., October 1, 2000; 165(7): 3584 - 3591. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
