| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
*
Centre for Inflammation Research, Department of Clinical and Surgical Sciences (Internal Medicine), Royal Infirmary, University of Edinburgh, Edinburgh, United Kingdom;
Department of Immunology, University of Glasgow, Glasgow, United Kingdom; and
Department of Medicine and Therapeutics, University of Aberdeen, Foresterhill, Aberdeen, United Kingdom
During inflammation in the glomerulus, the complement of resident
myofibroblast-like mesangial cells is regulated by mitosis and
apoptosis, but the cellular mechanisms controlling the size of
mesangial cell populations have remained obscure. Prompted by studies
of development, we sought evidence that macrophages regulate mesangial
cell number. Rat bone marrow-derived macrophages primed with IFN-
then further activated in coculture with LPS or TNF-
elicited a
10-fold induction of rat mesangial cell apoptosis and complete
suppression of mitosis, effects inhibitable by the NO synthase
inhibitors L-monomethyl arginine and
L-N6-(1-iminoethyl) lysine
dihydrochloride. Complete dependence upon macrophage-derived NO was
observed in comparable experiments employing activated bone marrow
macrophages from wild-type and NO synthase 2-/- mice.
Nevertheless, when mesangial cells were primed with IFN- plus
TNF-, increased induction by activated macrophages of mesangial
apoptosis exhibited a NO-independent element. The use of
gld/gld macrophages excluded a role for Fas ligand in
this residual kill, despite increased expression of Fas and increased
susceptibility to soluble Fas ligand exhibited by cytokine-primed
mesangial cells. Finally, activated macrophages isolated from the
glomeruli of rats with nephrotoxic nephritis also induced apoptosis and
suppressed mitosis in mesangial cells by an L-monomethyl
arginine-inhibitable mechanism. These data demonstrate that activated
macrophages, via the release of NO and other mediators, regulate
mesangial cell populations in vitro and may therefore control the
mesangial cell complement at inflamed sites.
This article has been cited by other articles:
|
|
 |
|
  M. H. Davies, A. J. Stempel, and M. R. Powers MCP-1 Deficiency Delays Regression of Pathologic Retinal Neovascularization in a Model of Ischemic Retinopathy Invest. Ophthalmol. Vis. Sci., September 1, 2008; 49(9): 4195 - 4202. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Henderson, A. C. Mackinnon, S. L. Farnworth, T. Kipari, C. Haslett, J. P. Iredale, F.-T. Liu, J. Hughes, and T. Sethi Galectin-3 Expression and Secretion Links Macrophages to the Promotion of Renal Fibrosis Am. J. Pathol., February 1, 2008; 172(2): 288 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. V. Dandapani, H. Sugimoto, B. D. Matthews, R. J. Kolb, S. Sinha, R. E. Gerszten, J. Zhou, D. E. Ingber, R. Kalluri, and M. R. Pollak {alpha}-Actinin-4 Is Required for Normal Podocyte Adhesion J. Biol. Chem., January 5, 2007; 282(1): 467 - 477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Duffield, S. Hong, V. S. Vaidya, Y. Lu, G. Fredman, C. N. Serhan, and J. V. Bonventre Resolvin D Series and Protectin D1 Mitigate Acute Kidney Injury J. Immunol., November 1, 2006; 177(9): 5902 - 5911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kipari, J.-F. Cailhier, D. Ferenbach, S. Watson, K. Houlberg, D. Walbaum, S. Clay, J. Savill, and J. Hughes Nitric Oxide Is an Important Mediator of Renal Tubular Epithelial Cell Death in Vitro and in Murine Experimental Hydronephrosis Am. J. Pathol., August 1, 2006; 169(2): 388 - 399. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Duffield, P. G. Tipping, T. Kipari, J.-F. Cailhier, S. Clay, R. Lang, J. V. Bonventre, and J. Hughes Conditional Ablation of Macrophages Halts Progression of Crescentic Glomerulonephritis Am. J. Pathol., November 1, 2005; 167(5): 1207 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-Q. Qiu, R. Sinniah, and S. I-H. Hsu Coupled Induction of iNOS and p53 Upregulation in Renal Resident Cells May Be Linked with Apoptotic Activity in the Pathogenesis of Progressive IgA Nephropathy J. Am. Soc. Nephrol., August 1, 2004; 15(8): 2066 - 2078. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Voskoboynik, B. Rinkevich, A. Weiss, E. Moiseeva, and A. Z. Reznick Macrophage involvement for successful degeneration of apoptotic organs in the colonial urochordate Botryllus schlosseri J. Exp. Biol., June 15, 2004; 207(14): 2409 - 2416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. W. M. Minto, L.-P. Erwig, and A. J. Rees Heterogeneity of Macrophage Activation in Anti-Thy-1.1 Nephritis Am. J. Pathol., November 1, 2003; 163(5): 2033 - 2041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Chen, C.-W. Chi, H.-L. Chen, C.-P. Wan, W.-C. Yang, and A.-H. Yang TNF-{alpha} renders human peritoneal mesothelial cells sensitive to anti-Fas antibody-induced apoptosis Nephrol. Dial. Transplant., September 1, 2003; 18(9): 1741 - 1747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-J. Anders, M. Frink, Y. Linde, B. Banas, M. Wornle, C. D. Cohen, V. Vielhauer, P. J. Nelson, H.-J. Grone, and D. Schlondorff CC Chemokine Ligand 5/RANTES Chemokine Antagonists Aggravate Glomerulonephritis Despite Reduction of Glomerular Leukocyte Infiltration J. Immunol., June 1, 2003; 170(11): 5658 - 5666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Weller, A. Schwentker, T. R. Billiar, and Y. Vodovotz Autologous nitric oxide protects mouse and human keratinocytes from ultraviolet B radiation-induced apoptosis Am J Physiol Cell Physiol, May 1, 2003; 284(5): C1140 - C1148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Lenda, E. Kikawada, E. R. Stanley, and V. R. Kelley Reduced Macrophage Recruitment, Proliferation, and Activation in Colony-Stimulating Factor-1-Deficient Mice Results in Decreased Tubular Apoptosis During Renal Inflammation J. Immunol., March 15, 2003; 170(6): 3254 - 3262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Banas, M. Wornle, T. Berger, P. J. Nelson, C. D. Cohen, M. Kretzler, J. Pfirstinger, M. Mack, M. Lipp, H.-J. Grone, et al. Roles of SLC/CCL21 and CCR7 in Human Kidney for Mesangial Proliferation, Migration, Apoptosis, and Tissue Homeostasis J. Immunol., May 1, 2002; 168(9): 4301 - 4307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Mene, F. Festuccia, R. Polci, F. Pugliese, and G. A. Cinotti Transmembrane signalling in human monocyte/mesangial cell co-cultures: role of cytosolic Ca2+ Nephrol. Dial. Transplant., January 1, 2002; 17(1): 42 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mazzali, T. Kipari, V. Ophascharoensuk, J.A. Wesson, R. Johnson, and J. Hughes Osteopontin--a molecule for all seasons QJM, January 1, 2002; 95(1): 3 - 13. [Full Text] [PDF]
|
|
|
|
|
|
M. Saio, S. Radoja, M. Marino, and A. B. Frey Tumor-Infiltrating Macrophages Induce Apoptosis in Activated CD8+ T Cells by a Mechanism Requiring Cell Contact and Mediated by Both the Cell-Associated Form of TNF and Nitric Oxide J. Immunol., November 15, 2001; 167(10): 5583 - 5593. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Freyer, S. R. Johnson, and I. P. Hall Effects of Growth Factors and Extracellular Matrix on Survival of Human Airway Smooth Muscle Cells Am. J. Respir. Cell Mol. Biol., November 1, 2001; 25(5): 569 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Duffield, C. F. Ware, B. Ryffel, and J. Savill Suppression by Apoptotic Cells Defines Tumor Necrosis Factor-Mediated Induction of Glomerular Mesangial Cell Apoptosis by Activated Macrophages Am. J. Pathol., October 1, 2001; 159(4): 1397 - 1404. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
