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*
Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, TX 78957; and
Department of Veterinary Sciences, University of Texas M. D. Anderson Cancer Center, Science Park-Veterinary Division, Bastrop, TX 78602
We previously reported that precursors within the keratin (K)
8+5+ thymic epithelial cell (TEC) subset
generate the major cortical K8+5- TEC
population in a process dependent on T lineage commitment. This report
demonstrates that expression of a cyclin D1 transgene in
K8+5+ TECs expands this subset and promotes TEC
and thymocyte development. Cyclin D1 transgene expression is not
sufficient to induce TEC differentiation in the absence of T
lineage-committed thymocytes because TECs from both hCD3
transgenic
and hCD3/cyclin D1 double transgenic mice remain blocked at the
K8+5+ maturation stage. However, enforced
cyclin D1 expression does expand the developmental window during which
K8+5+ cells can differentiate in response to
normal hemopoietic precursors. Thus, enhancement of thymic function may
be achieved by manipulating the growth and/or survival of TEC
precursors within the K8+5+
subset.
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