| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Departments of
*
Immunology and
Haematological Medicine, Guy’s, King’s, and St. Thomas’ School of Medicine, Rayne Institute, London, United Kingdom
Development of naive T cells into type 1 (Th1, Tc1) or type 2 (Th2, Tc2) effector cells is thought to be under the control of cytokines. In this study, we show that when both IL-12 and IL-4 are present, murine and human T cell differentiation is regulated by the balance of protein kinase C (PKC) and calcium signaling within T cells. Although both biochemical signals were required for T cell activation via the TCR, altering the balance between them redirected type 1 cells to type 2 and vice versa. Stimulation of calcium signaling or inhibition of PKC favored type 1 differentiation, whereas stimulation of PKC or inhibition of calcineurin resulted in type 2 effectors. Altered peptide ligands induced distinct balances of PKC/calcium signaling and altered Tc1/Tc2 development in TCR-transgenic CD8 T cells. The data suggest novel strategies for manipulation of the immune response in vivo.
This article has been cited by other articles:
|
|
 |
|
  M. Miyaji, R. L. Kortum, R. Surana, W. Li, K. D. Woolard, R. M. Simpson, L. E. Samelson, and C. L. Sommers Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice PNAS, August 25, 2009; 106(34): 14502 - 14507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Tahvanainen, T. Kallonen, H. Lahteenmaki, K. M. Heiskanen, J. Westermarck, K. V. S. Rao, and R. Lahesmaa PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation Blood, February 5, 2009; 113(6): 1268 - 1277. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Cannon, A. Collins, P. D. Mody, D. Balachandran, K. J. Henriksen, C. E. Smith, J. Tong, B. S. Clay, S. D. Miller, and A. I. Sperling CD43 Regulates Th2 Differentiation and Inflammation J. Immunol., June 1, 2008; 180(11): 7385 - 7393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Giorgini and A. Noble Blockade of chronic graft-versus-host disease by alloantigen-induced CD4+CD25+Foxp3+ regulatory T cells in nonlymphopenic hosts J. Leukoc. Biol., November 1, 2007; 82(5): 1053 - 1061. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. De Fanis, F. Mori, R. J. Kurnat, W. K. Lee, M. Bova, N. F. Adkinson, and V. Casolaro GATA3 up-regulation associated with surface expression of CD294/CRTH2: a unique feature of human Th cells Blood, May 15, 2007; 109(10): 4343 - 4350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zamorano, M. D. Rivas, F. Setien, and M. Perez-G Proteolytic Regulation of Activated STAT6 by Calpains J. Immunol., March 1, 2005; 174(5): 2843 - 2848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Krymskaya, W.-H. Lee, L. Zhong, and C.-P. Liu Polarized Development of Memory Cell-Like IFN-{gamma}-Producing Cells in the Absence of TCR {zeta}-Chain J. Immunol., February 1, 2005; 174(3): 1188 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Cho, L. A. Stanciu, S. T. Holgate, and S. L. Johnston Increased Interleukin-4, Interleukin-5, and Interferon-{gamma} in Airway CD4+ and CD8+ T Cells in Atopic Asthma Am. J. Respir. Crit. Care Med., February 1, 2005; 171(3): 224 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C. Switzer, D. N. McMurray, J. S. Morris, and R. S. Chapkin (n-3) Polyunsaturated Fatty Acids Promote Activation-Induced Cell Death in Murine T Lymphocytes J. Nutr., February 1, 2003; 133(2): 496 - 503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mukherjee, P. K. Maiti, and D. Nandi Role of CD80, CD86, and CTLA4 on mouse CD4+ T lymphocytes in enhancing cell-cycle progression and survival after activation with PMA and ionomycin J. Leukoc. Biol., November 1, 2002; 72(5): 921 - 931. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Middlebrook, C. Martina, Y. Chang, R. J. Lukas, and D. DeLuca Effects of Nicotine Exposure on T Cell Development in Fetal Thymus Organ Culture: Arrest of T Cell Maturation J. Immunol., September 15, 2002; 169(6): 2915 - 2924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Porter and N. A. Clipstone Sustained NFAT Signaling Promotes a Th1-Like Pattern of Gene Expression in Primary Murine CD4+ T Cells J. Immunol., May 15, 2002; 168(10): 4936 - 4945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gorak-Stolinska, J.-P. Truman, D. M. Kemeny, and A. Noble Activation-induced cell death of human T-cell subsets is mediated by Fas and granzyme B but is independent of TNF-{alpha} J. Leukoc. Biol., November 1, 2001; 70(5): 756 - 766. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Radoja, M. Saio, D. Schaer, M. Koneru, S. Vukmanovic, and A. B. Frey CD8+ Tumor-Infiltrating T Cells Are Deficient in Perforin-Mediated Cytolytic Activity Due to Defective Microtubule-Organizing Center Mobilization and Lytic Granule Exocytosis J. Immunol., November 1, 2001; 167(9): 5042 - 5051. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Blass, E. Pure, and C. A. Hunter A Role for CD44 in the Production of IFN-{{gamma}} and Immunopathology During Infection with Toxoplasma gondii J. Immunol., May 1, 2001; 166(9): 5726 - 5732. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
