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The Journal of Immunology, 2000, 164: 1730-1733.
Copyright © 2000 by The American Association of Immunologists

Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal Thymus1

Alison M. Michie, James R. Carlyle, Thomas M. Schmitt, Belma Ljutic, Sarah K. Cho, Quyen Fong and Juan Carlos Zúñiga-Pflücker2

Department of Immunology, University of Toronto, Toronto, Ontario, Canada

We recently described a population of fetal thymocytes with a CD117+NK1.1+CD90lowCD25- phenotype, which were shown to contain committed T cell and NK cell progenitors. However, the characterization of a single cell with a restricted T and NK cell precursor potential was lacking. Here, using an in vitro model for T and NK cell differentiation, we provide conclusive evidence demonstrating the existence of a clonal lineage-restricted T and NK cell progenitor. These results establish that fetal thymocytes with a CD117+NK1.1+CD90lowCD25- phenotype represent bipotent T and NK cell progenitors.




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