HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Chan, O. T. M. Articles by Shlomchik, M. J. Search for Related Content PubMed PubMed Citation Articles by Chan, O. T. M. Articles by Shlomchik, M. J.

Cutting Edge: B Cells Promote CD8⁺ T Cell Activation in MRL-Fas^lpr Mice Independently of MHC Class I Antigen Presentation¹

Owen T. M. Chan^* and Mark J. Shlomchik^2,*,

^* Section of Immunobiology and Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520

Spontaneous CD8⁺ T cell activation in MRL-Fas^lpr mice is B cell dependent. It is unclear whether this B-dependent activation is mediated by direct Ag presentation via MHC class I proteins (i.e., cross-presentation) or whether activation occurs by an indirect mechanism, e.g., via effects on CD4⁺ cells. To determine how CD8⁺ T cell activation is promoted by B cells, we created mixed bone marrow chimeras where direct MHC class I Ag presentation by B cells was abrogated while other leukocyte compartments could express MHC class I. Surprisingly, despite the absence of B cell class I-restricted Ag presentation, CD8⁺ T cell activation was intact in the chimeric mice. Therefore, the spontaneous B cell-dependent CD8⁺ T cell activation that occurs in systemic autoimmunity is not due to direct presentation by B cells to CD8⁺ T cells.

This article has been cited by other articles:

				Y. Li, F. Chen, M. Putt, Y. K. Koo, M. Madaio, J. C. Cambier, P. L. Cohen, and R. A. Eisenberg B Cell Depletion with Anti-CD79 mAbs Ameliorates Autoimmune Disease in MRL/lpr Mice J. Immunol., September 1, 2008; 181(5): 2961 - 2972. [Abstract] [Full Text] [PDF]

				Z. Yin, G. Bahtiyar, N. Zhang, L. Liu, P. Zhu, M. E. Robert, J. McNiff, M. P. Madaio, and J. Craft IL-10 Regulates Murine Lupus J. Immunol., August 15, 2002; 169(4): 2148 - 2155. [Abstract] [Full Text] [PDF]

				L. A. Trimble, K. A. Prince, G. A. Pestano, J. Daley, and H. Cantor Fas-Dependent Elimination of Nonselected CD8 Cells and lpr Disease J. Immunol., May 15, 2002; 168(10): 4960 - 4967. [Abstract] [Full Text] [PDF]