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CUTTING EDGE |
Department of Immunology, Genetics Institute, Cambridge, MA 02081
By the genetic selection of mouse cDNAs encoding secreted proteins, a B7-like cDNA clone termed mouse GL50 (mGL50) was isolated encoding a 322-aa polypeptide identical with B7h. Isolation of the human ortholog of this cDNA (hGL50) revealed a coding sequence of 309 aa residues with 42% sequence identity with mGL50. Northern analysis indicated GL50 to be present in many tissues including lymphoid, embryonic yolk sac, and fetal liver samples. Of the CD28, CTLA4, and ICOS fusion constructs tested, flow cytometric analysis demonstrated only mouse ICOS-IgG binding to mGL50 cell transfectants. Subsequent phenotyping demonstrated high levels of ICOS ligand staining on splenic CD19+ B cells and low levels on CD3+ T cells. These results indicate that GL50 is a specific ligand for the ICOS receptor and suggest that the GL50-ICOS interaction functions in lymphocyte costimulation.
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A. G. Tesciuba, S. Subudhi, R. P. Rother, S. J. Faas, A. M. Frantz, D. Elliot, J. Weinstock, L. A. Matis, J. A. Bluestone, and A. I. Sperling Inducible Costimulator Regulates Th2-Mediated Inflammation, but Not Th2 Differentiation, in a Model of Allergic Airway Disease J. Immunol., August 15, 2001; 167(4): 1996 - 2003. [Abstract] [Full Text] [PDF]
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J. J. Wallin, L. Liang, A. Bakardjiev, and W. C. Sha Enhancement of CD8+ T Cell Responses by ICOS/B7h Costimulation J. Immunol., July 1, 2001; 167(1): 132 - 139. [Abstract] [Full Text] [PDF]
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V. Ling, P. W. Wu, J. S. Miyashiro, S. Marusic, H. F. Finnerty, and M. Collins Differential Expression of Inducible Costimulator-Ligand Splice Variants: Lymphoid Regulation of Mouse GL50-B and Human GL50 Molecules J. Immunol., June 15, 2001; 166(12): 7300 - 7308. [Abstract] [Full Text] [PDF]
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J. Guo, M. Stolina, J. V. Bready, S. Yin, T. Horan, S. K. Yoshinaga, and G. Senaldi Stimulatory Effects of B7-Related Protein-1 on Cellular and Humoral Immune Responses in Mice J. Immunol., May 1, 2001; 166(9): 5578 - 5584. [Abstract] [Full Text] [PDF]
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H. Tamura, H. Dong, G. Zhu, G. L. Sica, D. B. Flies, K. Tamada, and L. Chen B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function Blood, March 15, 2001; 97(6): 1809 - 1816. [Abstract] [Full Text] [PDF]
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