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The Journal of Immunology, 2000, 164: 1648-1652.
Copyright © 2000 by The American Association of Immunologists

CUTTING EDGE

Cutting Edge: Role of B Lymphocytes in Protective Immunity Against Salmonella typhimurium Infection

Hans-Willi Mittrücker1, Bärbel Raupach, Anne Köhler and Stefan H. E. Kaufmann

Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany

Infection of mice with Salmonella typhimurium gives rise to a disease similar to human typhoid fever caused by S. typhi. Since S. typhimurium is a facultative intracellular bacterium, the requirement of B cells in the immune response against S. typhimurium is a longstanding matter of debate. By infecting mice on a susceptible background and deficient in B cells (Igµ-/- mice) with different strains of S. typhimurium, we could for the first time formally clarify the role of B cells in the response against S. typhimurium. Compared with Igµ+/+ mice, LD50 values in Igµ-/- mice were reduced during primary, and particularly secondary, oral infection with virulent S. typhimurium. After systemic infection, Igµ-/- mice cleared attenuated aroA- S. typhimurium, but vaccine-induced protection against systemic infection with virulent S. typhimurium involved both B cell-dependent and -independent effector mechanisms. Thus, B cell-mediated immunity plays a distinct role in control of S. typhimurium in susceptible mice.




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