| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany
Infection of mice with Salmonella typhimurium gives rise to a disease similar to human typhoid fever caused by S. typhi. Since S. typhimurium is a facultative intracellular bacterium, the requirement of B cells in the immune response against S. typhimurium is a longstanding matter of debate. By infecting mice on a susceptible background and deficient in B cells (Igµ-/- mice) with different strains of S. typhimurium, we could for the first time formally clarify the role of B cells in the response against S. typhimurium. Compared with Igµ+/+ mice, LD50 values in Igµ-/- mice were reduced during primary, and particularly secondary, oral infection with virulent S. typhimurium. After systemic infection, Igµ-/- mice cleared attenuated aroA- S. typhimurium, but vaccine-induced protection against systemic infection with virulent S. typhimurium involved both B cell-dependent and -independent effector mechanisms. Thus, B cell-mediated immunity plays a distinct role in control of S. typhimurium in susceptible mice.
This article has been cited by other articles:
|
|
 |
|
  A. Griffin, D. Baraho-Hassan, and S. J. McSorley Successful Treatment of Bacterial Infection Hinders Development of Acquired Immunity J. Immunol., July 15, 2009; 183(2): 1263 - 1270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Souwer, A. Griekspoor, T. Jorritsma, J. de Wit, H. Janssen, J. Neefjes, and S. M. van Ham B Cell Receptor-Mediated Internalization of Salmonella: A Novel Pathway for Autonomous B Cell Activation and Antibody Production J. Immunol., June 15, 2009; 182(12): 7473 - 7481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Li, S. Wang, W. Xin, G. Scarpellini, Z. Shi, B. Gunn, K. L. Roland, and R. Curtiss III A sopB Deletion Mutation Enhances the Immunogenicity and Protective Efficacy of a Heterologous Antigen Delivered by Live Attenuated Salmonella enterica Vaccines Infect. Immun., November 1, 2008; 76(11): 5238 - 5246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Schulz, G. Kohler, C. Holscher, Y. Iwakura, and G. Alber IL-17A is produced by Th17, {gamma}{delta} T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance Int. Immunol., September 1, 2008; 20(9): 1129 - 1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gaspal, V. Bekiaris, M.-Y. Kim, D. R. Withers, S. Bobat, I. C. M. MacLennan, G. Anderson, P. J. Lane, and A. F. Cunningham Critical Synergy of CD30 and OX40 Signals in CD4 T Cell Homeostasis and Th1 Immunity to Salmonella J. Immunol., March 1, 2008; 180(5): 2824 - 2829. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Benyacoub, F. Rochat, K.-Y. Saudan, I. Rochat, N. Antille, C. Cherbut, T. von der Weid, E. J. Schiffrin, and S. Blum Feeding a Diet Containing a Fructooligosaccharide Mix Can Enhance Salmonella Vaccine Efficacy in Mice J. Nutr., January 1, 2008; 138(1): 123 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Alaniz, B. L. Deatherage, J. C. Lara, and B. T. Cookson Membrane Vesicles Are Immunogenic Facsimiles of Salmonella typhimurium That Potently Activate Dendritic Cells, Prime B and T Cell Responses, and Stimulate Protective Immunity In Vivo J. Immunol., December 1, 2007; 179(11): 7692 - 7701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Herrada, F. J. Contreras, J. A. Tobar, R. Pacheco, and A. M. Kalergis Immune complex-induced enhancement of bacterial antigen presentation requires Fc{gamma} Receptor III expression on dendritic cells PNAS, August 14, 2007; 104(33): 13402 - 13407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Jones-Carson, B. D. McCollister, E. T. Clambey, and A. Vazquez-Torres Systemic CD8 T-Cell Memory Response to a Salmonella Pathogenicity Island 2 Effector Is Restricted to Salmonella enterica Encountered in the Gastrointestinal Mucosa Infect. Immun., June 1, 2007; 75(6): 2708 - 2716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Cunningham, F. Gaspal, K. Serre, E. Mohr, I. R. Henderson, A. Scott-Tucker, S. M. Kenny, M. Khan, K.-M. Toellner, P. J. L. Lane, et al. Salmonella Induces a Switched Antibody Response without Germinal Centers That Impedes the Extracellular Spread of Infection J. Immunol., May 15, 2007; 178(10): 6200 - 6207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Srinivasan, R.-M. Salazar-Gonzalez, M. Jarcho, M. M. Sandau, L. Lefrancois, and S. J. McSorley Innate Immune Activation of CD4 T Cells in Salmonella-Infected Mice Is Dependent on IL-18 J. Immunol., May 15, 2007; 178(10): 6342 - 6349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Srinivasan and S. J. McSorley Exposure to LPS suppresses CD4+ T cell cytokine production in Salmonella-infected mice and exacerbates murine typhoid J. Leukoc. Biol., February 1, 2007; 81(2): 403 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Konjufca, S.-Y. Wanda, M. C. Jenkins, and R. Curtiss III A Recombinant Attenuated Salmonella enterica Serovar Typhimurium Vaccine Encoding Eimeria acervulina Antigen Offers Protection against E. acervulina Challenge Infect. Immun., December 1, 2006; 74(12): 6785 - 6796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-T.A. Teng Protective and Destructive Immunity in the Periodontium: Part 1--Innate and Humoral Immunity and the Periodontium Journal of Dental Research, March 1, 2006; 85(3): 198 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Yager, C. Bitsaktsis, B. Nandi, J. W. McBride, and G. Winslow Essential Role for Humoral Immunity during Ehrlichia Infection in Immunocompetent Mice Infect. Immun., December 1, 2005; 73(12): 8009 - 8016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Bergman, L. A. Cummings, R. C. Alaniz, L. Mayeda, I. Fellnerova, and B. T. Cookson CD4+-T-Cell Responses Generated during Murine Salmonella enterica Serovar Typhimurium Infection Are Directed towards Multiple Epitopes within the Natural Antigen FliC Infect. Immun., November 1, 2005; 73(11): 7226 - 7235. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ravindran, J. Foley, T. Stoklasek, L. H. Glimcher, and S. J. McSorley Expression of T-bet by CD4 T Cells Is Essential for Resistance to Salmonella Infection J. Immunol., October 1, 2005; 175(7): 4603 - 4610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Devito, B. Zuber, U. Schroder, R. Benthin, K. Okuda, K. Broliden, B. Wahren, and J. Hinkula Intranasal HIV-1-gp160-DNA/gp41 Peptide Prime-Boost Immunization Regimen in Mice Results in Long-Term HIV-1 Neutralizing Humoral Mucosal and Systemic Immunity J. Immunol., December 1, 2004; 173(11): 7078 - 7089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Tobar, P. A. Gonzalez, and A. M. Kalergis Salmonella Escape from Antigen Presentation Can Be Overcome by Targeting Bacteria to Fc{gamma} Receptors on Dendritic Cells J. Immunol., September 15, 2004; 173(6): 4058 - 4065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ugrinovic, N. Menager, N. Goh, and P. Mastroeni Characterization and Development of T-Cell Immune Responses in B-Cell-Deficient (Igh-6-/-) Mice with Salmonella enterica Serovar TyphimuriumInfection Infect. Immun., December 1, 2003; 71(12): 6808 - 6819. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Mastroeni, and N. Menager Development of acquired immunity to Salmonella J. Med. Microbiol., June 1, 2003; 52(6): 453 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsui, M. Suzuki, Y. Isshiki, C. Kodama, M. Eguchi, Y. Kikuchi, K. Motokawa, A. Takaya, T. Tomoyasu, and T. Yamamoto Oral Immunization with ATP-Dependent Protease-Deficient Mutants Protects Mice against Subsequent Oral Challenge with Virulent Salmonella enterica Serovar Typhimurium Infect. Immun., January 1, 2003; 71(1): 30 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Buendia, L. Del Rio, N. Ortega, J. Sanchez, M. C. Gallego, M. R. Caro, J. A. Navarro, F. Cuello, and J. Salinas B-Cell-Deficient Mice Show an Exacerbated Inflammatory Response in a Model of Chlamydophila abortus Infection Infect. Immun., December 1, 2002; 70(12): 6911 - 6918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. Kirby, U. Yrlid, and M. J. Wick The Innate Immune Response Differs in Primary and Secondary Salmonella Infection J. Immunol., October 15, 2002; 169(8): 4450 - 4459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Koesling, T. Aebischer, C. Falch, R. Schulein, and C. Dehio Cutting Edge: Antibody-Mediated Cessation of Hemotropic Infection by the Intraerythrocytic Mouse Pathogen Bartonella grahamii J. Immunol., July 1, 2001; 167(1): 11 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Morrison and R. P. Morrison Resolution of Secondary Chlamydia trachomatis Genital Tract Infection in Immune Mice with Depletion of Both CD4+ and CD8+ T cells Infect. Immun., April 1, 2001; 69(4): 2643 - 2649. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Shu-yi Li, E. Yager, M. Reilly, C. Freeman, G. R. Reddy, A. A. Reilly, F. K. Chu, and G. M. Winslow Outer Membrane Protein-Specific Monoclonal Antibodies Protect SCID Mice from Fatal Infection by the Obligate Intracellular Bacterial Pathogen Ehrlichia chaffeensis J. Immunol., February 1, 2001; 166(3): 1855 - 1862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. G. Morrison, H. Su, H. D. Caldwell, and R. P. Morrison Immunity to Murine Chlamydia trachomatis Genital Tract Reinfection Involves B Cells and CD4+ T Cells but Not CD8+ T Cells Infect. Immun., December 1, 2000; 68(12): 6979 - 6987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Szalai, J. L. VanCott, J. R. McGhee, J. E. Volanakis, and W. H. Benjamin Jr. Human C-Reactive Protein Is Protective against Fatal Salmonella enterica Serovar Typhimurium Infection in Transgenic Mice Infect. Immun., October 1, 2000; 68(10): 5652 - 5656. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
