| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Agonists1
Departments of
*
Medicine,
Pharmacology, and
Physiology, Medical University of South Carolina, Charleston, SC 29403;
§
Medical Research Service, Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29403; and
¶
Vanderbilt University School of Medicine, Nashville, TN 37232
MRL/Mp-lpr/lpr
(MRL/lpr) mice develop immune complex glomerulonephritis
similar to human lupus. Glomerular mesangial cells are key modulators
of the inflammatory response in lupus nephritis. When activated, these
cells secrete inflammatory mediators including NO and products of
cyclooxygenase perpetuating the local inflammatory response.
PGJ2, a product of cyclooxygenase, is a potent in vitro
inhibitor of macrophage inflammatory functions and is postulated to
function as an in vivo inhibitor of macrophage-mediated inflammatory
responses. We hypothesized that in lupus, a defect in PGJ2
production allows the inflammatory response to continue unchecked. To
test this hypothesis, mesangial cells were isolated from
MRL/lpr and BALB/c mice and stimulated with IL-1ß or
LPS plus IFN-
. In contrast to the 2- to 3-fold increase in
PGJ2 production by stimulated BALB/c mesangial cells,
supernatant PGJ2 did not increase in MRL/lpr
mesangial cell cultures. NO production in stimulated
MRL/lpr and BALB/c mesangial cells, was blocked by
PGJ2 and pioglitazone. These studies suggest that
abnormalities in PGJ2 production are present in
MRL/lpr mice and may be linked to the heightened
activation state of mesangial cells in these
mice.
This article has been cited by other articles:
|
|
 |
|
  H. J. Yoon, S.-B. Jeon, I.-H. Kim, and E. J. Park Regulation of TLR2 Expression by Prostaglandins in Brain Glia J. Immunol., June 15, 2008; 180(12): 8400 - 8409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Dong, Q-X Wang, C-Y Zhou, X-F Ma, and Y-C Zhang Activation of the STAT1 signalling pathway in lupus nephritis in MRL/lpr mice Lupus, February 1, 2007; 16(2): 101 - 109. [Abstract] [PDF]
|
|
|
|
 |
|
 A. J. Jimenez-Caliani, S. Jimenez-Jorge, P. Molinero, J. M. Fernandez-Santos, I. Martin-Lacave, A. Rubio, J. M. Guerrero, and C. Osuna Sex-Dependent Effect of Melatonin on Systemic Erythematosus Lupus Developed in Mrl/Mpj-Faslpr Mice: It Ameliorates the Disease Course in Females, whereas It Exacerbates It in Males Endocrinology, April 1, 2006; 147(4): 1717 - 1724. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ji, H. J. Kim, Y. H. Rho, S. J. Choi, Y. H. Lee, H. J. Cheon, J. Sohn, and G. G. Song Inhibition of IL-10-induced STAT3 activation by 15-deoxy-{Delta}12,14-prostaglandin J2 Rheumatology, August 1, 2005; 44(8): 983 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. E. Berry, J. A. Keelan, R. J. A. Helliwell, R. S. Gilmour, and M. D. Mitchell Nanomolar and Micromolar Effects of 15-Deoxy-{Delta}12,14-prostaglandin J2 on Amnion-Derived WISH Epithelial Cells: Differential Roles of Peroxisome Proliferator-Activated Receptors {gamma} and {delta} and Nuclear Factor {kappa}B Mol. Pharmacol., July 1, 2005; 68(1): 169 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Crosby, J. L. Svenson, J. Zhang, C. J. Nicol, F. J. Gonzalez, and G. S. Gilkeson Peroxisome Proliferation-Activated Receptor (PPAR){gamma} Is Not Necessary for Synthetic PPAR{gamma} Agonist Inhibition of Inducible Nitric-Oxide Synthase and Nitric Oxide J. Pharmacol. Exp. Ther., January 1, 2005; 312(1): 69 - 76. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Reilly, N. Mishra, J. M. Miller, D. Joshi, P. Ruiz, V. M. Richon, P. A. Marks, and G. S. Gilkeson Modulation of Renal Disease in MRL/lpr Mice by Suberoylanilide Hydroxamic Acid J. Immunol., September 15, 2004; 173(6): 4171 - 4178. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Cheng, H. Afif, J. Martel-Pelletier, J.-P. Pelletier, X. Li, K. Farrajota, M. Lavigne, and H. Fahmi Activation of Peroxisome Proliferator-activated Receptor {gamma} Inhibits Interleukin-1{beta}-induced Membrane-associated Prostaglandin E2 Synthase-1 Expression in Human Synovial Fibroblasts by Interfering with Egr-1 J. Biol. Chem., May 21, 2004; 279(21): 22057 - 22065. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K. Chatterjee, N. S.A Patel, S. Cuzzocrea, P. A.J Brown, K. N Stewart, H. Mota-Filipe, D. Britti, W. Eberhardt, J. Pfeilschifter, and C. Thiemermann The cyclopentenone prostaglandin 15-deoxy-{Delta}12,14-prostaglandin J2 ameliorates ischemic acute renal failure Cardiovasc Res, February 15, 2004; 61(3): 630 - 643. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Perez-Sala, E. Cernuda-Morollon, and F. J. Canada Molecular Basis for the Direct Inhibition of AP-1 DNA Binding by 15-Deoxy-{Delta}12,14-prostaglandin J2 J. Biol. Chem., December 19, 2003; 278(51): 51251 - 51260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Masuya, C. J. Drake, P. A. Fleming, C. M. Reilly, H. Zeng, W. D. Hill, A. Martin-Studdard, D. C. Hess, and M. Ogawa Hematopoietic origin of glomerular mesangial cells Blood, March 15, 2003; 101(6): 2215 - 2218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. B. Clark The role of PPARs in inflammation and immunity J. Leukoc. Biol., March 1, 2002; 71(3): 388 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Scholz-Pedretti, A. Gans, K.-F. Beck, J. Pfeilschifter, and M. Kaszkin Potentiation of TNF-{alpha}-Stimulated Group IIA Phospholipase A2 Expression by Peroxisome Proliferator-Activated Receptor {alpha} Activators in Rat Mesangial Cells J. Am. Soc. Nephrol., March 1, 2002; 13(3): 611 - 620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. H. ROVIN, L. LU, and A. COSIO Cyclopentenone Prostaglandins Inhibit Cytokine-Induced NF-{kappa}B Activation and Chemokine Production by Human Mesangial Cells J. Am. Soc. Nephrol., August 1, 2001; 12(8): 1659 - 1667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Sekine, C. M. Reilly, I. D. Molano, G. Garnier, A. Circolo, P. Ruiz, V. M. Holers, S. A. Boackle, and G. S. Gilkeson Complement Component C3 Is Not Required for Full Expression of Immune Complex Glomerulonephritis in MRL/lpr Mice J. Immunol., May 15, 2001; 166(10): 6444 - 6451. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Guyton, R. Bond, C. Reilly, G. Gilkeson, P. Halushka, and J. Cook Differential effects of 15-deoxy-{Delta}12,14-prostaglandin J2 and a peroxisome proliferator-activated receptor {gamma} agonist on macrophage activation J. Leukoc. Biol., April 1, 2001; 69(4): 631 - 638. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. B. Nicholas, Y. Kawano, S. Wakino, A. R. Collins, and W. A. Hsueh Expression and Function of Peroxisome Proliferator-Activated Receptor-{{gamma}} in Mesangial Cells Hypertension, February 1, 2001; 37(2): 722 - 727. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
